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The RNA tailing enzymes TENT4b and TENT2 protect against \u03b2-amyloid\u2013 and \u03b1-synuclein\u2013induced toxicity by facilitating the formation of nontoxic amyloidogenic assemblies. In contrast, the RNA exonuclease Exosc10 potentiates pathological amyloid toxicity. Remarkably, Exosc10 depletion prevents cognitive decline and restores memory in two different mouse models of \u03b2-amyloid neurotoxicity. Taken together, these results suggest that pathways of physiological amyloidogenesis participate in pathological amyloid etiology.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202503493","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:00:11Z","timestamp":1773860411000},"page":"e202503493","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Enzymes of physiological amyloidogenesis control pathological amyloid toxicity"],"prefix":"10.26508","volume":"9","author":[{"given":"Michael","family":"Bokros","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02dgjyy92","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami","place":[", Miami, FL, USA"]},{"id":[{"id":"https:\/\/ror.org\/02dgjyy92","id-type":"ROR","asserted-by":"publisher"}],"name":"Sylvester 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