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To search for such shared pathways, we performed transcriptomic analysis of iPSC-derived dopaminergic neurons from patients with\n                    <jats:italic>LRRK2<\/jats:italic>\n                    or\n                    <jats:italic>Parkin<\/jats:italic>\n                    mutations. We discovered a convergent gene expression signature in both genetic backgrounds, indicating a shift away from developmental and proliferative programs (e.g., Wnt\/\u03b2-catenin signaling, cell cycle) and toward pathways of mature neuronal function (e.g., synaptic transmission, potassium channels). This shift was particularly pronounced in\n                    <jats:italic>LRRK2<\/jats:italic>\n                    neurons, which showed enhanced markers of synaptic maturation. Concurrently, PD neurons exhibited down-regulation of gene programs supporting axon growth and structural development and upregulated TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway. Our findings suggest that in these hereditary forms of PD, distinct mutations may propel neurons toward a similar state of premature specialization coupled with impaired structural development and increased vulnerability, revealing a potential common path in disease pathogenesis.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202503551","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:21:49Z","timestamp":1774678909000},"page":"e202503551","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson\u2019s disease"],"prefix":"10.26508","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0258-0291","authenticated-orcid":true,"given":"Irina 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