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Denervation attenuated ketonuria in high-fat diet\u2013fed rats. The phosphorylation of AKT, PI3K, and ERK1\/2 in the kidney was modulated by interactions among diet, renal sympathetic input, and time. These findings indicate that renal sympathetic nerves contribute to early stages of metabolic dysregulation, whereas prolonged hypercaloric exposure overrides autonomic control and promotes cardiovascular and renal complications.<\/jats:p>","DOI":"10.26508\/lsa.202503568","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:35:18Z","timestamp":1784050518000},"page":"e202503568","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["The onset of hypertension in metabolic syndrome is independent of renal sympathetic innervation"],"prefix":"10.26508","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0906-1288","authenticated-orcid":true,"given":"Omar","family":"Flores-Sandoval","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000917t60","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratorio de Neuroanatom\u00eda Funcional, Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed","place":[", San Luis Potos\u00ed, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-7493","authenticated-orcid":true,"given":"Skarleth","family":"C\u00e1rdenas-Romero","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000917t60","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratorio de Neuroanatom\u00eda Funcional, Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed","place":[", San Luis Potos\u00ed, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-6100","authenticated-orcid":true,"given":"Adri\u00e1n","family":"B\u00e1ez-Ruiz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000917t60","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratorio de Ritmos Biol\u00f3gicos, Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed","place":[", San Luis Potos\u00ed, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5230-962X","authenticated-orcid":true,"given":"Roberto C","family":"Salgado-Delgado","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000917t60","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratorio de Ritmos Biol\u00f3gicos, Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed","place":[", San Luis Potos\u00ed, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-987X","authenticated-orcid":true,"given":"Nadia","family":"Saderi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/000917t60","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratorio de Neuroanatom\u00eda Funcional, Facultad de Ciencias, Universidad Aut\u00f3noma de San Luis Potos\u00ed","place":[", San Luis Potos\u00ed, M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12380","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026071410351314000_9.10.e202503568.1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.313"},{"key":"2026071410351314000_9.10.e202503568.2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.313"},{"key":"2026071410351314000_9.10.e202503568.3","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"2026071410351314000_9.10.e202503568.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.09.007"},{"key":"2026071410351314000_9.10.e202503568.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2012.12.003"},{"key":"2026071410351314000_9.10.e202503568.6","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7394"},{"key":"2026071410351314000_9.10.e202503568.7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00488.2009"},{"key":"2026071410351314000_9.10.e202503568.8","doi-asserted-by":"publisher","DOI":"10.1016\/J.PEPTIDES.2009.10.012"},{"key":"2026071410351314000_9.10.e202503568.9","doi-asserted-by":"publisher","DOI":"10.1007\/S00424-008-0498-1"},{"key":"2026071410351314000_9.10.e202503568.10","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.079855"},{"key":"2026071410351314000_9.10.e202503568.11","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.104398"},{"key":"2026071410351314000_9.10.e202503568.12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00344.2010"},{"key":"2026071410351314000_9.10.e202503568.13","unstructured":"Comstock JP , Garber AJ (1990) Ketonuria. 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