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Alliance"],"accepted":{"date-parts":[[2026,6,26]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    Oxygen-sensing and the hypoxia stress response play vital roles in physiological homeostasis. Subterranean species that are naturally adapted to hypoxia provide powerful tools for understanding the mechanisms of hypoxia tolerance. The plateau zokor\n                    <jats:italic>Eospalax baileyi<\/jats:italic>\n                    and the Gansu zokor\n                    <jats:italic>Eospalax cansus,<\/jats:italic>\n                    which inhabit the Qinghai\u2013Tibet Plateau of China, and the blind mole rat\n                    <jats:italic>Spalax galili,<\/jats:italic>\n                    which lives in Israel, are all subterranean rodents adapted to hypoxic environments. Here, we showed that the T480S variant of the hypoxia-inducible factor-2\u0251 (encoded by the endothelial PAS domain protein 1 gene,\n                    <jats:italic>Epas1<\/jats:italic>\n                    ) in Chinese zokors stabilized EPAS1 by reducing phosphorylation, thereby regulating fibrosis and contributing to hypoxia adaptation on the Qinghai\u2013Tibet Plateau. In Israeli blind mole rats, variants at positions -2023\/-1810 in the\n                    <jats:italic>Epas1<\/jats:italic>\n                    regulatory region distinguish two abutting populations undergoing incipient sympatric speciation by altering the binding of cMYB and hepatocyte nuclear factor 4 gamma, linking transcriptional activity to the interferon mRNA transcription. This finding reveals an adaptive regulation of metabolism and O\n                    <jats:sub>2<\/jats:sub>\n                    homeostasis by the\n                    <jats:italic>Epas1<\/jats:italic>\n                    gene in adaptation to diverse habitats, providing evidence for both divergent and convergent functional molecular evolution.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202603622","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:00:17Z","timestamp":1784566817000},"page":"e202603622","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Variants of\n                    <i>Epas1<\/i>\n                    contribute to hypoxia adaptation in the subterranean rodents\n                    <i>Eospalax<\/i>\n                    and\n                    <i>Spalax<\/i>"],"prefix":"10.26508","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-2504","authenticated-orcid":true,"given":"Yibin","family":"Cao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01vevwk45","id-type":"ROR","asserted-by":"publisher"}],"name":"College of Chemistry and Life Science, Zhejiang Normal University","place":[", Jinhua, China"]},{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Department of Neurology of the Second Affiliated Hospital, School of Brain Sciences and Brain Medicine, Zhejiang University, Hangzhou, 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