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By investigating a noncoding RNA (ncRNA) partner derived from the\n                    <jats:italic>MEIS1<\/jats:italic>\n                    promoter, we demonstrated that its KD triggers\n                    <jats:italic>MEIS1<\/jats:italic>\n                    down-regulation, markedly reducing NPC proliferative capacity. RNA-sequencing further indicated that\n                    <jats:italic>MEIS1<\/jats:italic>\n                    regulates genes involved in cholesterol biogenesis. Specifically, forced expression of\n                    <jats:italic>DHCR7<\/jats:italic>\n                    , a\n                    <jats:italic>MEIS1<\/jats:italic>\n                    -target gene, rescued both the proliferative deficits and the reduction in primary cilia length induced by\n                    <jats:italic>MEIS1<\/jats:italic>\n                    KD. These findings suggest that ncRNA-mediated regulatory mechanism for the conserved\n                    <jats:italic>MEIS1<\/jats:italic>\n                    coordinates primary cilia morphology and cholesterol metabolism. This coordination is essential for maintaining long-term NPC properties, ultimately contributing to the evolutionary expansion of the human cerebral cortex.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202603708","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:21:29Z","timestamp":1789712489000},"page":"e202603708","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Human-biased\n                    <i>MEIS1<\/i>\n                    expression by a promoter noncoding RNA regulates neural stem cell proliferation"],"prefix":"10.26508","volume":"9","author":[{"given":"Hayato","family":"Uchida","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t78wx29","id-type":"ROR","asserted-by":"publisher"}],"name":"Program of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University","place":[", Higashi-Hiroshima, 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