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Disruption of the N-eEF1A1 interaction, genetically or pharmacologically using the eEF1A interactant plitidepsin, abolished transcriptional complex formation and reversed host gene dysregulation, identifying a conserved host\u2013virus regulatory axis and potential pan-variant therapeutic target.<\/jats:p>","DOI":"10.26508\/lsa.202603751","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:21:27Z","timestamp":1790317287000},"page":"e202603751","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["SARS-CoV-2 nucleocapsid protein hijacks host transcription by targeting eEF1A1"],"prefix":"10.26508","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-8717","authenticated-orcid":true,"given":"Baptiste","family":"Bidon","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05bqach95","id-type":"ROR","asserted-by":"publisher"}],"name":"Taiwan International 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