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Alliance"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer\u2019s disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas \u03b2-amyloid (A\u03b2) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A\u03b2 intersect intracellularly. We show that internalized astrocytic ApoE localizes mostly to lysosomes in neuroblastoma cells and astrocytes, whereas in neurons, it preferentially localizes to endosomes\u2013autophagosomes of neurites. In AD transgenic neurons, astrocyte-derived ApoE intersects intracellularly with amyloid precursor protein\/A\u03b2. Moreover, ApoE4 increases the levels of endogenous and internalized A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    in neurons. Taken together, we demonstrate differential localization of ApoE in neurons, astrocytes, and neuron-like cells, and show that internalized ApoE intersects with amyloid precursor protein\/A\u03b2 in neurons, which may be of considerable relevance to AD.\n                  <\/jats:p>","DOI":"10.26508\/lsa.202201887","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T13:52:20Z","timestamp":1686837140000},"page":"e202201887","update-policy":"https:\/\/doi.org\/10.26508\/lsa.crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Apolipoprotein E intersects with amyloid-\u03b2 within neurons"],"prefix":"10.26508","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-2779","authenticated-orcid":true,"given":"Sabine C","family":"Konings","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/012a77v79","id-type":"ROR","asserted-by":"publisher"}],"name":"Experimental Dementia Research Unit, Department of 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