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We also show<jats:italic>Dm<\/jats:italic>IFT88 binding to the cyclase\u00b4s intracellular part, which is evolutionarily conserved and mutated in several degenerative retinal diseases, is important for the ciliary localisation of<jats:italic>Dm<\/jats:italic>Gucy2d. Finally, acute knockdown of both<jats:italic>Dm<\/jats:italic>IFT88 and<jats:italic>Dm<\/jats:italic>Gucy2d in ciliated neurons of adult flies caused defects in the maintenance of cilium function, impairing hearing and negative-gravitaxis behaviour, but did not significantly affect ciliary ultrastructure. 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