{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:07:33Z","timestamp":1780582053052,"version":"3.54.1"},"reference-count":59,"publisher":"Tsinghua University Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.26599\/joto.2025.9540038","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:38:17Z","timestamp":1762997897000},"page":"245-252","source":"Crossref","is-referenced-by-count":1,"title":["A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study"],"prefix":"10.26599","volume":"20","author":[{"given":"Zhencheng","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11138","reference":[{"issue":"3","key":"ref1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1177\/1971400920913868","article-title":"White-matter integrity and hearing acuity decline in healthy subjects: Magnetic resonance tractography","volume":"33","author":"F.H. Alhazmi","year":"2020","unstructured":"F.H. Alhazmi. White-matter integrity and hearing acuity decline in healthy subjects: Magnetic resonance tractography. 2020, 33(3): 236-243.","journal-title":"Neuroradiol. J."},{"issue":"4","key":"ref2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1192\/bjp.bp.114.153536","article-title":"Lifetime hypertension as a predictor of brain structure in older adults: Cohort study with a 28-year follow-up","volume":"206","author":"C.L. Allan","year":"2015","unstructured":"C.L. Allan. Lifetime hypertension as a predictor of brain structure in older adults: Cohort study with a 28-year follow-up. 2015, 206(4): 308-315.","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"ref3","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41467-019-08500-x","article-title":"Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults","volume":"10","author":"N. Bittner","year":"2019","unstructured":"N. Bittner. Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults. 2019, 10(1): 621.","journal-title":"Nat. Commun."},{"issue":"6","key":"ref4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.biopsych.2014.12.030","article-title":"Cortical surface area differentiates familial high risk individuals who go on to develop schizophrenia","volume":"78","author":"C. Bois","year":"2015","unstructured":"C. Bois. Cortical surface area differentiates familial high risk individuals who go on to develop schizophrenia. 2015, 78(6): 413-420.","journal-title":"Biol. Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.bbr.2014.10.010","article-title":"Brain structure and cognitive correlates of body mass index in healthy older adults","volume":"278","author":"J.D. Bolzenius","year":"2015","unstructured":"J.D. Bolzenius. Brain structure and cognitive correlates of body mass index in healthy older adults. 2015, 278: 342-347.","journal-title":"Behav. Brain Res."},{"issue":"2","key":"ref6","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression","volume":"44","author":"J. Bowden","year":"2015","unstructured":"J. Bowden. Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression. 2015, 44(2): 512-525.","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"ref7","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"J. Bowden","year":"2016","unstructured":"J. Bowden. Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator. 2016, 40(4): 304-314.","journal-title":"Genet. Epidemiol."},{"issue":"11","key":"ref8","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1007\/s40520-023-02570-0","article-title":"Age-related changes in auditory perception","volume":"35","author":"D. Brotto","year":"2023","unstructured":"D. Brotto. Age-related changes in auditory perception. 2023, 35(11): 2349-2354.","journal-title":"Hearing loss in the elderly: Aging ear or aging brain? Aging Clin. Exp. Res."},{"issue":"(Pt 3)","key":"ref9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: A review of its functional anatomy and behavioural correlates","volume":"129","author":"A.E. Cavanna","year":"2006","unstructured":"A.E. Cavanna. The precuneus: A review of its functional anatomy and behavioural correlates. 2006, 129((Pt 3)): 564-583.","journal-title":"Brain"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1208581","DOI":"10.3389\/fnins.2023.1208581","article-title":"Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation","volume":"17","author":"Y.C. Chang","year":"2023","unstructured":"Y.C. Chang. Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation. 2023, 17: 1208581.","journal-title":"Front. Neurosci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"103592","DOI":"10.1016\/j.ebiom.2021.103592","article-title":"Kidney damage causally affects the brain cortical structure: A Mendelian randomization study","volume":"72","author":"X. Chen","year":"2021","unstructured":"X. Chen. Kidney damage causally affects the brain cortical structure: A Mendelian randomization study. 2021, 72: 103592.","journal-title":"eBioMedicine"},{"issue":"2","key":"ref12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1176\/appi.neuropsych.11080180","article-title":"Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): Imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression","volume":"24","author":"V.A. Coenen","year":"2012","unstructured":"V.A. Coenen. Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): Imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression. 2012, 24(2): 223-236.","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"R1","key":"ref13","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: Genetic anchors for causal inference in epidemiological studies","volume":"23","author":"G. Davey Smith","year":"2014","unstructured":"G. Davey Smith. Mendelian randomization: Genetic anchors for causal inference in epidemiological studies. 2014, 23(R1): R89-R98.","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"ref14","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s10162-012-0332-5","article-title":"Auditory cortex signs of age-related hearing loss","volume":"13","author":"M.A. Eckert","year":"2012","unstructured":"M.A. Eckert. Auditory cortex signs of age-related hearing loss. 2012, 13(5): 703-713.","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1177\/2331216519857267","author":"","unstructured":"","journal-title":"null"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"120285","DOI":"10.1016\/j.neuroimage.2023.120285","article-title":"A multidimensional characterization of the neurocognitive architecture underlying age-related temporal speech processing","volume":"278","author":"S. Elmer","year":"2023","unstructured":"S. Elmer. A multidimensional characterization of the neurocognitive architecture underlying age-related temporal speech processing. 2023, 278: 120285.","journal-title":"NeuroImage"},{"issue":"8","key":"ref17","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1002\/hbm.26283","article-title":"General dimensions of human brain morphometry inferred from genome-wide association data","volume":"44","author":"F\u00fcrtjes","year":"2023","unstructured":"F\u00fcrtjes. General dimensions of human brain morphometry inferred from genome-wide association data. 2023, 44(8): 3311-3323.","journal-title":"Hum. Brain Mapp."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.heares.2016.08.012","article-title":"Cross-modal plasticity in developmental and age-related hearing loss: Clinical implications","volume":"343","author":"H. Glick","year":"2017","unstructured":"H. Glick. Cross-modal plasticity in developmental and age-related hearing loss: Clinical implications. 2017, 343: 191-201.","journal-title":"Hear. Res."},{"issue":"5","key":"ref19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/MOO.0000000000000387","article-title":"Brain changes associated with age-related hearing loss","volume":"25","author":"J.S. Golub","year":"2017","unstructured":"J.S. Golub. Brain changes associated with age-related hearing loss. 2017, 25(5): 347-352.","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"issue":"6484","key":"ref20","doi-asserted-by":"publisher","first-page":"eaay6690","DOI":"10.1126\/science.aay6690","article-title":"The genetic architecture of the human cerebral cortex","volume":"367","author":"K.L. Grasby","year":"2020","unstructured":"K.L. Grasby. The genetic architecture of the human cerebral cortex. 2020, 367(6484): eaay6690.","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"101445","DOI":"10.1016\/j.arr.2021.101445","article-title":"Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies","volume":"71","author":"Y.P. Han","year":"2021","unstructured":"Y.P. Han. Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies. 2021, 71: 101445.","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"ref22","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1093\/ije\/dyx028","article-title":"Two-sample Mendelian randomization: Avoiding the downsides of a powerful, widely applicable but potentially fallible technique","volume":"45","author":"F.P. Hartwig","year":"2016","unstructured":"F.P. Hartwig. Two-sample Mendelian randomization: Avoiding the downsides of a powerful, widely applicable but potentially fallible technique. 2016, 45(6): 1717-1726.","journal-title":"Int. J. Epidemiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"G. Hemani","year":"2018","unstructured":"G. Hemani. The MR-Base platform supports systematic causal inference across the human phenome. 2018, 7: e34408.","journal-title":"eLife"},{"issue":"1","key":"ref24","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41598-020-80218-z","article-title":"Decreasing auditory input induces neurogenesis impairment in the hippocampus","volume":"11","author":"T. Kurioka","year":"2021","unstructured":"T. Kurioka. Decreasing auditory input induces neurogenesis impairment in the hippocampus. 2021, 11(1): 423.","journal-title":"Sci. Rep."},{"issue":"47","key":"ref25","doi-asserted-by":"publisher","first-page":"4913","DOI":"10.1093\/eurheartj\/ehad736","article-title":"Mendelian randomization for cardiovascular diseases: Principles and applications","volume":"44","author":"S.C. Larsson","year":"2023","unstructured":"S.C. Larsson. Mendelian randomization for cardiovascular diseases: Principles and applications. 2023, 44(47): 4913-4924.","journal-title":"Eur. Heart J."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/978-3-319-50406-3_6","article-title":"Hippocampal development: Structure, function and implications","author":"J.K. Lee","year":"2017","unstructured":"J.K. Lee. Hippocampal development: Structure, function and implications. 2017","journal-title":"In: The Hippocampus from Cells to Systems"},{"issue":"7","key":"ref27","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1093\/cercor\/bhv107","article-title":"Dissociations in cortical morphometry in youth with down syndrome: Evidence for reduced surface area but increased thickness","volume":"26","author":"N.R. Lee","year":"2016","unstructured":"N.R. Lee. Dissociations in cortical morphometry in youth with down syndrome: Evidence for reduced surface area but increased thickness. 2016, 26(7): 2982-2990.","journal-title":"Cereb. Cortex"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"119861","DOI":"10.1016\/j.neuroimage.2023.119861","article-title":"Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis","volume":"268","author":"N. Li","year":"2023","unstructured":"N. Li. Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis. 2023, 268: 119861.","journal-title":"NeuroImage"},{"issue":"2","key":"ref29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1001\/archneurol.2010.362","article-title":"Hearing loss and incident dementia","volume":"68","author":"F.R. Lin","year":"2011","unstructured":"F.R. Lin. Hearing loss and incident dementia. 2011, 68(2): 214-220.","journal-title":"Arch Neurol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neuroimage.2013.12.059","article-title":"Association of hearing impairment with brain volume changes in older adults","volume":"90","author":"F.R. Lin","year":"2014","unstructured":"F.R. Lin. Association of hearing impairment with brain volume changes in older adults. 2014, 90: 84-92.","journal-title":"NeuroImage"},{"issue":"16","key":"ref31","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1016\/j.neuron.2023.04.023","article-title":"20 years of the default mode network: A review and synthesis","volume":"111","author":"V. Menon","year":"2023","unstructured":"V. Menon. 20 years of the default mode network: A review and synthesis. 2023, 111(16): 2469-2487.","journal-title":"Neuron"},{"issue":"9","key":"ref33","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1093\/brain\/awac105","article-title":"Elucidating the relationship between migraine risk and brain structure using genetic data","volume":"145","author":"B.L. Mitchell","year":"2022","unstructured":"B.L. Mitchell. Elucidating the relationship between migraine risk and brain structure using genetic data. 2022, 145(9): 3214-3224.","journal-title":"Brain"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1177\/23312165241236041","author":"","unstructured":"","journal-title":"null"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"106024","DOI":"10.1016\/j.nbd.2023.106024","article-title":"Noise-induced auditory damage affects hippocampus causing memory deficits in a model of early age-related hearing loss","volume":"178","author":"F. Paciello","year":"2023","unstructured":"F. Paciello. Noise-induced auditory damage affects hippocampus causing memory deficits in a model of early age-related hearing loss. 2023, 178: 106024.","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"ref36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0962280210394459","article-title":"Using multiple genetic variants as instrumental variables for modifiable risk factors","volume":"21","author":"T.M. Palmer","year":"2012","unstructured":"T.M. Palmer. Using multiple genetic variants as instrumental variables for modifiable risk factors. 2012, 21(3): 223-242.","journal-title":"Stat. Methods Med. Res."},{"issue":"11","key":"ref37","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1093\/cercor\/bhp026","article-title":"Distinct genetic influences on cortical surface area and cortical thickness","volume":"19","author":"M.S. Panizzon","year":"2009","unstructured":"M.S. Panizzon. Distinct genetic influences on cortical surface area and cortical thickness. 2009, 19(11): 2728-2735.","journal-title":"Cereb. Cortex"},{"issue":"7","key":"ref38","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1093\/aje\/kwt084","article-title":"Efficient design for Mendelian randomization studies: Subsample and 2-sample instrumental variable estimators","volume":"178","author":"B.L. Pierce","year":"2013","unstructured":"B.L. Pierce. Efficient design for Mendelian randomization studies: Subsample and 2-sample instrumental variable estimators. 2013, 178(7): 1177-1184.","journal-title":"Am. J. Epidemiol."},{"issue":"8","key":"ref39","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1002\/hbm.24538","article-title":"Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI","volume":"40","author":"S. Ponticorvo","year":"2019","unstructured":"S. Ponticorvo. Cortical pattern of reduced perfusion in hearing loss revealed by ASL-MRI. 2019, 40(8): 2475-2487.","journal-title":"Hum. Brain Mapp."},{"issue":"4862","key":"ref40","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1126\/science.3291116","article-title":"Specification of cerebral cortical areas","volume":"241","author":"P. Rakic","year":"1988","unstructured":"P. Rakic. Specification of cerebral cortical areas. 1988, 241(4862): 170-176.","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"744","DOI":"10.3389\/fnins.2018.00744","article-title":"Gray matter atrophy is associated with cognitive impairment in patients with presbycusis: A comprehensive morphometric study","volume":"12","author":"F.X. Ren","year":"2018","unstructured":"F.X. Ren. Gray matter atrophy is associated with cognitive impairment in patients with presbycusis: A comprehensive morphometric study. 2018, 12: 744.","journal-title":"Front. Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"649874","DOI":"10.3389\/fnagi.2021.649874","article-title":"Brain frequency-specific changes in the spontaneous neural activity are associated with cognitive impairment in patients with presbycusis","volume":"13","author":"F.X. Ren","year":"2021","unstructured":"F.X. Ren. Brain frequency-specific changes in the spontaneous neural activity are associated with cognitive impairment in patients with presbycusis. 2021, 13: 649874.","journal-title":"Front. Aging Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fnagi.2017.00002","article-title":"Hearing impairment is associated with smaller brain volume in aging","volume":"9","author":"S.C. Rigters","year":"2017","unstructured":"S.C. Rigters. Hearing impairment is associated with smaller brain volume in aging. 2017, 9: 2.","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"ref44","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1007\/s00429-020-02148-w","article-title":"Neuroanatomical changes associated with age-related hearing loss and listening effort","volume":"225","author":"S. Rosemann","year":"2020","unstructured":"S. Rosemann. Neuroanatomical changes associated with age-related hearing loss and listening effort. 2020, 225(9): 2689-2700.","journal-title":"Brain Struct. Funct."},{"issue":"1","key":"ref45","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/13576500342000310","article-title":"Does brain white matter growth expand the cortex like a balloon? Hypothesis and consequences","volume":"10","author":"H.L. Seldon","year":"2005","unstructured":"H.L. Seldon. Does brain white matter growth expand the cortex like a balloon? Hypothesis and consequences. 2005, 10(1): 81-95.","journal-title":"Laterality"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"105408","DOI":"10.1016\/j.nbd.2021.105408","article-title":"Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons","volume":"156","author":"Y.L. Shen","year":"2021","unstructured":"Y.L. Shen. Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons. 2021, 156: 105408.","journal-title":"Neurobiol. Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1276883","DOI":"10.3389\/fnins.2023.1276883","article-title":"Hippocampal atrophy is associated with hearing loss in cognitively normal adults","volume":"17","author":"Y.J. Shim","year":"2023","unstructured":"Y.J. Shim. Hippocampal atrophy is associated with hearing loss in cognitively normal adults. 2023, 17: 1276883.","journal-title":"Front. Neurosci."},{"issue":"25","key":"ref48","doi-asserted-by":"publisher","first-page":"8488","DOI":"10.1523\/JNEUROSCI.0391-14.2014","article-title":"Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span: Regions of accelerating and decelerating change","volume":"34","author":"A.B. Storsve","year":"2014","unstructured":"A.B. Storsve. Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span: Regions of accelerating and decelerating change. 2014, 34(25): 8488-8498.","journal-title":"J. Neurosci."},{"issue":"Suppl 2","key":"ref49","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1002\/ohn.750","article-title":"Clinical practice guideline: Age-related hearing loss","volume":"170","author":"B.S. Tsai Do","year":"2024","unstructured":"B.S. Tsai Do. Clinical practice guideline: Age-related hearing loss. 2024, 170(Suppl 2): S1-S54.","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"4","key":"ref50","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.tics.2011.02.001","article-title":"Frontal pole cortex: Encoding ends at the end of the endbrain","volume":"15","author":"S. Tsujimoto","year":"2011","unstructured":"S. Tsujimoto. Frontal pole cortex: Encoding ends at the end of the endbrain. 2011, 15(4): 169-176.","journal-title":"Trends Cogn. Sci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3389\/fnagi.2018.00319","article-title":"Smaller hippocampal volume and degraded peripheral hearing among Japanese community dwellers","volume":"10","author":"Y. Uchida","year":"2018","unstructured":"Y. Uchida. Smaller hippocampal volume and degraded peripheral hearing among Japanese community dwellers. 2018, 10: 319.","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"ref52","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s11357-024-01393-9","article-title":"Impact of age-related hearing loss on decompensation of left DLPFC during speech perception in noise: A combined EEG-fNIRS study","volume":"47","author":"S.J. Wang","year":"2025","unstructured":"S.J. Wang. Impact of age-related hearing loss on decompensation of left DLPFC during speech perception in noise: A combined EEG-fNIRS study. 2025, 47(2): 2119-2134.","journal-title":"Geroscience"},{"issue":"6","key":"ref53","doi-asserted-by":"publisher","first-page":"e3000307","DOI":"10.1371\/journal.pbio.3000307","article-title":"Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models","volume":"17","author":"W.H. Wang","year":"2019","unstructured":"W.H. Wang. Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models. 2019, 17(6): e3000307.","journal-title":"PLoS Biol."},{"issue":"1","key":"ref54","doi-asserted-by":"publisher","first-page":"6878","DOI":"10.1038\/s41598-024-57510-3","article-title":"Resting-state functional connectivity and structural differences between smokers and healthy non-smokers","volume":"14","author":"C. Weidler","year":"2024","unstructured":"C. Weidler. Resting-state functional connectivity and structural differences between smokers and healthy non-smokers. 2024, 14(1): 6878.","journal-title":"Sci. Rep."},{"issue":"4","key":"ref55","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1093\/cercor\/bhm115","article-title":"Volume of left Heschl\u2019s Gyrus and linguistic pitch learning","volume":"18","author":"P.C.M. Wong","year":"2008","unstructured":"P.C.M. Wong. Volume of left Heschl\u2019s Gyrus and linguistic pitch learning. 2008, 18(4): 828-836.","journal-title":"Cereb. Cortex"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ejim.2023.10.018","article-title":"Systolic blood pressure is associated with abnormal alterations in brain cortical structure: Evidence from a Mendelian randomization study","volume":"120","author":"Z.L. Ye","year":"2024","unstructured":"Z.L. Ye. Systolic blood pressure is associated with abnormal alterations in brain cortical structure: Evidence from a Mendelian randomization study. 2024, 120: 92-98.","journal-title":"Eur. J. Intern. Med."},{"issue":"8","key":"ref57","doi-asserted-by":"publisher","first-page":"e27422","DOI":"10.1016\/j.heliyon.2024.e27422","article-title":"Causal association and mediating effect of blood biochemical metabolic traits and brain image-derived endophenotypes on Alzheimer\u2019s disease","volume":"10","author":"K.F. Yin","year":"2024","unstructured":"K.F. Yin. Causal association and mediating effect of blood biochemical metabolic traits and brain image-derived endophenotypes on Alzheimer\u2019s disease. 2024, 10(8): e27422.","journal-title":"Heliyon"},{"issue":"1","key":"ref58","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1080\/13651501.2022.2129067","article-title":"Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naive schizophrenia","volume":"27","author":"H.X. Zhou","year":"2023","unstructured":"H.X. Zhou. Association of reduced cortical thickness and psychopathological symptoms in patients with first-episode drug-naive schizophrenia. 2023, 27(1): 42-50.","journal-title":"Int. J. Psychiatry Clin. Pract."},{"issue":"19","key":"ref59","doi-asserted-by":"publisher","first-page":"19493","DOI":"10.18632\/aging.103898","article-title":"Accelerated age-related decline in hippocampal neurogenesis in mice with noise-induced hearing loss is associated with hippocampal microglial degeneration","volume":"12","author":"H. Zhuang","year":"2020","unstructured":"H. Zhuang. Accelerated age-related decline in hippocampal neurogenesis in mice with noise-induced hearing loss is associated with hippocampal microglial degeneration. 2020, 12(19): 19493-19519.","journal-title":"Aging"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.bbi.2023.09.002","article-title":"Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss","volume":"114","author":"H. Zhuang","year":"2023","unstructured":"H. Zhuang. Voluntary wheel exercise ameliorates cognitive impairment, hippocampal neurodegeneration and microglial abnormalities preceded by demyelination in a male mouse model of noise-induced hearing loss. 2023, 114: 325-348.","journal-title":"Brain, Behav. Immun."}],"container-title":["Journal of Otology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:38:18Z","timestamp":1762997898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciopen.com\/article\/10.26599\/JOTO.2025.9540038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.26599\/joto.2025.9540038","relation":{},"ISSN":["1672-2930","2524-1753"],"issn-type":[{"value":"1672-2930","type":"print"},{"value":"2524-1753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}