{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T07:13:13Z","timestamp":1649142793490},"reference-count":35,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,12]]},"abstract":"<p><bold>Objective.<\/bold> <italic>The aim of this study was to analyze the effects of individual low socioeconomic status (SES) and deprived geographical area (GA) on the occurrence of isolated cleft lip with or without cleft palate (CL\u00b1P) in Argentina<\/italic>.<\/p>\n<p><bold>Methods.<\/bold> <italic>This case-control study included 577 newborns with isolated CL\u00b1P and 13 344 healthy controls, born between 1992 and 2001, from a total population of 546 129 births in 39 hospitals in Argentina. Census data on unsatisfied basic needs were used to establish the degree of geographical area deprivation. An SES index for each individual was established, using maternal age, gravidity, low paternal and maternal education, and low-level paternal occupation. Logistic regression was used to assess the effects of low SES and of deprived GA on CL\u00b1P<\/italic>.<\/p>\n<p><bold>Results.<\/bold> <italic>A slightly increased risk of CL\u00b1P was observed in mothers with a low SES, while a deprived GA showed no effect. Native ancestry, acute maternal illnesses, and poor prenatal care were significant risk factors for CL\u00b1P for the mothers with low SES, after using propensity scores to adjust for the demographic characteristics in cases and controls<\/italic>.<\/p>\n<p><bold>Conclusions.<\/bold> <italic>Low individual SES slightly increased the risk for CL\u00b1P, but a deprived GA did not have that effect. There was no interaction between individual SES and deprived GA. Factors related to low individual SES\u2014including poor prenatal care, low parental education, lack of information, and lifestyle factors\u2014should be primarily targeted as risk factors for CL\u00b1P rather than factors related to a deprived place of residence<\/italic>.<\/p>","DOI":"10.26633\/rpsp.2017.110","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T10:52:51Z","timestamp":1563792771000},"page":"1","source":"Crossref","is-referenced-by-count":1,"title":["Individual deprivation, regional deprivation, and risk for oral clefts in Argentina"],"prefix":"10.26633","volume":"41","author":[{"given":"Mariela Soledad","family":"Pawluk","sequence":"first","affiliation":[{"name":"Estudio Colaborativo Latinoamericano de Malformaciones Cong\u00e9nitas (ECLAMC), Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC-CONICET), Buenos Aires, Argentina."},{"name":"m_s_pawluk@outlook.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebe","family":"Campa\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Rittler","sequence":"additional","affiliation":[{"name":"Estudio Colaborativo Latinoamericano de Malformaciones Cong\u00e9nitas (ECLAMC), Hospital Materno Infantil Ram\u00f3n Sarda, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Adri\u00e1n","family":"Poletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana R.","family":"Cosentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Gili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Gabriel","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Santiago","family":"L\u00f3pez Camelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","unstructured":"1. 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