{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:05:39Z","timestamp":1755695139627},"reference-count":50,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,26]]},"abstract":"<p><bold>Objetivo.<\/bold> <italic>Analizar los resultados con respecto a la reactividad del cortisol (RC) ante un paradigma de estr\u00e9s experimental en adultos con o sin alg\u00fan trastorno psiqui\u00e1trico que sufrieron violencia en etapas tempranas de desarrollo (infancia y adolescencia temprana) y con ello proponer una herramienta cl\u00ednica para el establecimiento de indicadores biol\u00f3gicos de estr\u00e9s<\/italic>.<\/p>\n<p><bold>M\u00e9todos.<\/bold> <italic>Se realiz\u00f3 una revisi\u00f3n sistem\u00e1tica en diversas bases de datos, siguiendo los criterios PRISMA; de un total de 231 art\u00edculos, 16 cumplieron los criterios de inclusi\u00f3n y los resultados fueron analizados de manera cualitativa<\/italic>.<\/p>\n<p><bold>Resultados.<\/bold> <italic>A pesar de la heterogeneidad, los resultados sugieren que las personas que sufrieron violencia temprana presentan un patr\u00f3n de baja RC. Contrariamente, la poblaci\u00f3n que adem\u00e1s desarroll\u00f3 s\u00edntomas de trastorno de estr\u00e9s postraum\u00e1tico y depresi\u00f3n, independientemente del tipo de violencia, mostr\u00f3 incrementada RC. La mayor\u00eda de los trabajos se centraron en poblaci\u00f3n que sufri\u00f3 abuso sexual en la infancia y la mitad de los art\u00edculos apoya la hip\u00f3tesis de que la RC es m\u00e1s pronunciada en hombres que en mujeres<\/italic>.<\/p>\n<p><bold>Conclusiones.<\/bold> <italic>Los resultados de esta revisi\u00f3n nos permiten sugerir que es posible considerar la hiperreactividad del cortisol como un biomarcador para el tratamiento e intervenci\u00f3n de poblaci\u00f3n con trastorno de estr\u00e9s postraum\u00e1tico y depresi\u00f3n que sufrieron violencia temprana. Adem\u00e1s, apoyan la evidencia de que sufrir violencia altera la respuesta del estr\u00e9s y la salud mental a largo plazo. Sin embargo, es necesario realizar m\u00e1s estudios principalmente los que se refieren a la hiporreactividad y a las diferencias de g\u00e9nero<\/italic>.<\/p>","DOI":"10.26633\/rpsp.2017.171","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T12:38:11Z","timestamp":1516970291000},"page":"1","source":"Crossref","is-referenced-by-count":5,"title":["Reactividad del cortisol y salud mental en adultos expuestos a violencia temprana: revisi\u00f3n sistem\u00e1tica"],"prefix":"10.26633","volume":"41","author":[{"given":"Ana Lilia","family":"Cerda-Molina","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Ciudad de M\u00e9xico, M\u00e9xico. La correspondencia se debe dirigir a Ana Lilia Cerda-Molina. alcm@imp.edu.mx"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier Iv\u00e1n","family":"Borr\u00e1z-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian","family":"Mayagoitia-Novales","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Teresita","family":"Gaspar Del R\u00edo","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","unstructured":"1. Organizaci\u00f3n Mundial de la Salud (OMS). Informe Sobre la Situaci\u00f3n Mundial de la Prevenci\u00f3n de la Violencia. Ginebra. Organizaci\u00f3n Mundial de la Salud; 2014."},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"2. Krug EG, Mercy JA, Dahlberg LL, Zwi AB. The world report on violence and health. The lancet. 2002;360:1083\u20131088.","DOI":"10.1016\/S0140-6736(02)11133-0"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"3. Kochanska G, Tjebkes JL, Fortnan DR. Children\u2019s emerging regulation of conduct: Restraint, compliance, and internalization from infancy to the second year. Child Dev. 1998;69(5):1378\u20131389.","DOI":"10.2307\/1132272"},{"key":"ref4","unstructured":"4. Copeland WE, Keeler G, Angold A, Costello E. Traumatic events and posttraumatic stress in childhood. Arch. Gen. Psychiatry 2007;64(5):577\u2013584."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"5. Elzinga BM, Roelofs K, Tollenaar MS, Bakvis P, van Pelt J, Spinhoven P. Diminished cortisol responses to psychosocial stress associated with lifetime adverse events: a study among healthy young subjects. Psychoneuroendocrinology. 2008;33(2):227\u2013237.","DOI":"10.1016\/j.psyneuen.2007.11.004"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"6. Margolin G, Gordis EB. The effects of family and community violence on children. Annu Rev Psychol. 2000;51:445\u2013479.","DOI":"10.1146\/annurev.psych.51.1.445"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"7. Aiyer SM, Heinze JE, Miller AL, Stoddard SA, Zimmerman MA. Exposure to violence predicting cortisol response during adolescence and early adulthood: Understanding moderating factors. J Youth Adolesc. 2014;43(7):1066\u20131079.","DOI":"10.1007\/s10964-014-0097-8"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"8. McFarland MJ, Hayward MD. Poverty and Awakening Cortisol in Adolescence: The Importance of Timing in Early Life. Soc Ment Health. 2014;4(1):21\u201337.","DOI":"10.1177\/2156869313500278"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"9. DeJonghe ES, Bogat GA, Levendosky AA, Von Eye A, Davidson WS. Infant exposure to domestic violence predicts heightened sensitivity to adult verbal conflict. Infant Ment Health J. 2005;26(3):268\u2013281.","DOI":"10.1002\/imhj.20048"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"10. Mullen PE, Martin JL, Anderson JC, Romans SE, Herbison GP. The long-term impact of the physical, emotional, and sexual abuse of children: A community study. Child Abuse Negl. 1996;20(1):7\u201321.","DOI":"10.1016\/0145-2134(95)00112-3"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"11. McEwen BS, Seeman T. Protective and damaging effects of mediators of stress: elaborating and testing the concepts of allostasis and allostatic load. Ann N Y Acad Sci. 1999;896:30\u201347.","DOI":"10.1111\/j.1749-6632.1999.tb08103.x"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"12. Rivier CL, Plotsky PM. Mediation by corticotropin releasing factor (CRF) of adenohypophysial hormone secretion. Annu Rev Physiol. 1986;48:475\u2013494.","DOI":"10.1146\/annurev.ph.48.030186.002355"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"13. Lupien SJ, McEwen BS. The acute effects of corticosteroids on cognitive: Integration of animal and human model studies. Brain Res Rev. 1997;24(1):1\u201327.","DOI":"10.1016\/S0165-0173(97)00004-0"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"14. Sapolsky RM. The influence of social hierarchy on primate health. Science. 2005;308(5722): 648\u2013652.","DOI":"10.1126\/science.1106477"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"15. Fulford AJ, Harbuz MS. An introduction to the HPA axis. En: Steckler T, Kalin NH, Reul JMHM, editors. Handbook of Stress and the Brain Part 1: The Neurobiology of Stress, 15. Amsterdam: Elsevier; 2005. p. 43\u201365.","DOI":"10.1016\/S0921-0709(05)80006-9"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"16. Miller GE, Chen E, Zhou ES. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull. 2007;133(1): 25\u201345.","DOI":"10.1037\/0033-2909.133.1.25"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"17. Inslicht SS, Marmar CR, Neylan TC, Metzler TJ, Hart SL, Otte C, Baum A. Increased cortisol in women with intimate partner violence-related posttraumatic stress disorder. Psychoneuroendocrinology. 2006;31(7):825\u2013838.","DOI":"10.1016\/j.psyneuen.2006.03.007"},{"key":"ref18","unstructured":"18. Danese A, McEwen BS. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol. Behav 2012;106(1):29\u201339."},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"19. Koob GF, Rassnick S, Heinrichs S, Weiss F. Alcohol, the reward system and dependence. En: Jansson B, J\u00f6rnvall H, Rydberg U, Terenius L, editors. Toward a Molecular Basis of Alcohol Use and Abuse. Switzerland: Birkh\u00e4user Basel; 1994. p. 103\u2013114.","DOI":"10.1007\/978-3-0348-7330-7_11"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"20. Bernardy, NC, King AC, Parsons OA, Lovallo WR. Altered cortisol response in sober alcoholics: an examination of contributing factors. Alcohol. 1996;13(5):493\u2013498.","DOI":"10.1016\/0741-8329(96)00043-2"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"21. Elzinga BM, Schmahl CG, Vermetten E, van Dyck R, Bremner JD. Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology. 2003;28(9):1656\u20131665.","DOI":"10.1038\/sj.npp.1300226"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"22. Yehuda R. Current status of cortisol findings in post-traumatic stress disorder. Psychiatr Clin North Am. 2002;25(2):341\u2013368.","DOI":"10.1016\/S0193-953X(02)00002-3"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"23. Juruena MF. Early-life stress and HPA axis trigger recurrent adulthood depression. Epilepsy Behav. 2014;38:148\u2013159.","DOI":"10.1016\/j.yebeh.2013.10.020"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"24. Juul SH, Hendrix C, Robinson B, Stowe ZN, Newport DJ, Brennan PA, Johnson KC. Maternal early-life trauma and affective parenting style: the mediating role of HPA-axis function. Arch Womens Ment Health. 2015;19(1):17\u201323.","DOI":"10.1007\/s00737-015-0528-x"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"25. Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Jama. 2000;284(5):592\u2013597.","DOI":"10.1001\/jama.284.5.592"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"26. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull. 2004;130(3):355\u2013391.","DOI":"10.1037\/0033-2909.130.3.355"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"27. Kirchbaum C, W\u00fcst S, Hellhammer DH. Consistent sex differences in cortisol responses to psychological stress. Psychosom Med. 1992;54(6):648\u2013657.","DOI":"10.1097\/00006842-199211000-00004"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"28. Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol Psychology. 2005;69(1):113\u2013132.","DOI":"10.1016\/j.biopsycho.2004.11.009"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"29. Burke HM, Davis MC, Otte C, Mohr DC. Depression and cortisol responses to psychological stress: a meta-analysis. Psychoneuroendocrinology. 2005; 30(9):846\u2013856.","DOI":"10.1016\/j.psyneuen.2005.02.010"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"30. Schechter DS, Zeanah CH, Myers MM, Brunelli SA, Liebowitz MR, Marshall RD, et al. Psychobiological dysregulation in violence-exposed mothers with very young children pre- and post- separation stress. Bull Menninger Clin. 2004;68(4):319\u2013336.","DOI":"10.1521\/bumc.68.4.319.56642"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"31. Lovallo WR, Farag NH, Sorocco KH, Cohoon AJ, Vincent AS. Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project. Biol Psychiatry. 2012;71(4):344\u2013349.","DOI":"10.1016\/j.biopsych.2011.10.018"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"32. Elzinga BM, Roelofs K, Tollenaar MS, Bakvis P, van Pelt J, Spinhoven P. Diminished cortisol responses to psychosocial stress associated with lifetime adverse events: a study among healthy young subjects. Psychoneuroendocrinology. 2008;33(2):227\u2013237.","DOI":"10.1016\/j.psyneuen.2007.11.004"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"33. Schalinski I, Elbert T, Steudte-Schmiedgen S, Kirschbaum C. The cortisol paradox of trauma-related disorders: Lower phasic responses but higher tonic levels of cortisol are associated with sexual abuse in childhood. PloS one. 2015;10(8): e0136921.","DOI":"10.1371\/journal.pone.0136921"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"34. Bremner JD, Vythilingam MV, Vermetten E, Adil J, Khan S, Nazeer A, Heninger G. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology. 2003;28(6):733\u2013750.","DOI":"10.1016\/S0306-4530(02)00067-7"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"35. Brand SR, Brennan PA, Newport DJ, Smith AK, Weiss T, Stowe ZN. The impact of maternal childhood abuse on maternal and infant HPA axis function in the postpartum period. Psychoneuroendocrinology. 2010;35(5):686\u2013693.","DOI":"10.1016\/j.psyneuen.2009.10.009"},{"key":"ref36","unstructured":"36. Carpenter LL, Carvalho JP, Tyrka AR, Wier LM, Mello AF, Mello MF, et al. Decreased ACTH and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol. Psychiatry 2007;62(10):1080\u20131087."},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"37. Gola H, Engler H, Schauer M, Adenauer H, Riether C, Kolassa S, et al. Victims of rape show increased cortisol responses to trauma reminders: A study in individuals with war-and torture-related PTSD. Psychoneuroendocrinology. 2012;37(2):213\u2013220.","DOI":"10.1016\/j.psyneuen.2011.06.005"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"38. van der Hal-Van Raalte EA, Bakermans-Kranenburg MJ, van Ijzendoorn MH. Diurnal cortisol patterns and stress reactivity in child Holocaust survivors reaching old age. Aging Men Health. 2008;12(5):630\u2013638.","DOI":"10.1080\/13607860802343134"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"39. Brenner AB, Zimmerman MA, Bauermeister JA, Caldwell CH. The physiological expression of living in disadvantaged neighborhoods for youth. J Youth Adolesc. 2013;42(6):792\u2013806.","DOI":"10.1007\/s10964-012-9838-8"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"40. Aloia LS, Solomon DH. Conflict intensity, family history, and physiological stress reactions to conflict within romantic relationships. Human Communication Research. 2015;41: 367\u2013389.","DOI":"10.1111\/hcre.12049"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"41. Kolassa IT, Eckart C, Ruf M, Neuner F, de Quervain DJF, Elbert T. Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) undergoing a diagnostic interview. BMC Psychiatry. 2007;7:54.","DOI":"10.1186\/1471-244X-7-54"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"42. Kirschbaum C, Kudielka BM, Gaab J, Schommer NC, Hellhammer DH. Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis. Psychosomatic Medicine. 1999;61:154\u2013162.","DOI":"10.1097\/00006842-199903000-00006"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"43. Cicchetti D, Gunnar MR. Integrating biological measures into the design and evaluation of preventive interventions. Dev Psychopathol. 2008;20(3):737\u2013743.","DOI":"10.1017\/S0954579408000357"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"44. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386\u2013389.","DOI":"10.1126\/science.1083968"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"45. Bradley RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, et al. Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry. 2008;65(2):190\u2013200.","DOI":"10.1001\/archgenpsychiatry.2007.26"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"46. Huesmann LR. The role of social information processing and cognitive schema in the acquisition and maintenance of habitual aggressive behavior. En: Green RG, Donnerstein E, editors. Human Aggression: Theories, Research, and Implications for Social Policy. New York: Academic Press; 1998. p. 73\u2013109.","DOI":"10.1016\/B978-012278805-5\/50005-5"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"47. Geisser ME, Roth RS, Bachman JE, Eckert TA. The relationship between symptoms of post-traumatic stress disorder and pain, affective disturbance and disability among patients with accident and non-accident related pain. Pain. 1996;66(2-3):207\u2013214.","DOI":"10.1016\/0304-3959(96)03038-2"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"48. Stam R. PTSD and stress sensitisation: A tale of brain and body: Part 1: Human studies. Neurosci Biobehav Rev. 2007;31(4):530\u2013557.","DOI":"10.1016\/j.neubiorev.2006.11.010"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"49. Herrera AY, Nielsen SE, Mather M. Stress-induced increases in progesterone and cortisol in naturally cycling women. Neurobiol Stress. 2016;3:96\u2013104.","DOI":"10.1016\/j.ynstr.2016.02.006"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"50. Sorocco K H, Lovallo WR, Vincent AS, Collins FL. Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism. Int J Psychophysiol. 2006;59(3):210\u2013217.","DOI":"10.1016\/j.ijpsycho.2005.10.009"}],"container-title":["Revista Panamericana de Salud P\u00fablica"],"original-title":[],"language":"es","link":[{"URL":"http:\/\/iris.paho.org\/xmlui\/bitstream\/handle\/123456789\/34572\/v41e1712017.pdf?sequence=5&isAllowed=y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T14:21:59Z","timestamp":1572618119000},"score":1,"resource":{"primary":{"URL":"http:\/\/iris.paho.org\/xmlui\/handle\/123456789\/34572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,26]]},"references-count":50,"alternative-id":["RPSP.2017.171"],"URL":"https:\/\/doi.org\/10.26633\/rpsp.2017.171","relation":{},"ISSN":["1020-4989","1680-5348"],"issn-type":[{"value":"1020-4989","type":"print"},{"value":"1680-5348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,26]]}}}