{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T15:51:11Z","timestamp":1723218671698},"reference-count":33,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<p><bold>Objetivo.<\/bold> Describir las caracter\u00edsticas sociodemogr\u00e1ficas y cl\u00ednico-epidemiol\u00f3gicas y determinar los factores asociados a la mortalidad de personas con diagn\u00f3stico de tuberculosis en Paraguay.<\/p>\n<p><bold>M\u00e9todos.<\/bold> Investigaci\u00f3n operativa con un dise\u00f1o de cohortes retrospectivo de los casos diagnosticados con TB en Paraguay entre 2015-2016. Se utiliz\u00f3 la base datos del Programa Nacional de Control de Tuberculosis. Para determinar los factores asociados con mortalidad se utilizaron pruebas chi cuadrado y riesgo relativo (RR) con un intervalo de confianza de 95% (IC95%); adem\u00e1s, se ajust\u00f3 un modelo de regresi\u00f3n m\u00faltiple de Poisson robusto. Se utiliz\u00f3 un nivel de significaci\u00f3n de 5%.<\/p>\n<p><bold>Resultados.<\/bold> Se estudiaron 5 141 casos de TB, de los cuales 11,5% fallecieron, los factores que aumentan el riesgo de muerte fueron: sexo masculino (RR: 1,26 IC; 95%: 1,1-1,50), infecci\u00f3n con virus de la inmunodeficiencia humana (VIH) (RR: 4,78; IC 95%: 4,04-5,65) y enfermedad pulmonar obstructiva cr\u00f3nica (RR: 1,70; IC 95%: 1,19-2,42). Como factor protector se identific\u00f3 ser persona privada de la libertad (RR: 0,37 IC 95%: 0,24-0,61).<\/p>\n<p><bold>Conclusiones.<\/bold> El mayor riesgo de muerte lo presentan los hombres y las personas con coinfecci\u00f3n TB\/VIH y el menor riesgo, las personas privadas de la libertad. Es necesario mejorar el diagn\u00f3stico y seguimiento a los casos de TB, con la efectiva implementaci\u00f3n del tratamiento directamente observado (TDO) as\u00ed como el manejo oportuno de enfermedades asociadas como VIH y enfermedad pulmonar obstructica cr\u00f3nica (EPOC).<\/p>","DOI":"10.26633\/rpsp.2019.102","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T14:46:06Z","timestamp":1576766766000},"page":"1","source":"Crossref","is-referenced-by-count":5,"title":["Factores asociados a la mortalidad por tuberculosis en Paraguay, 2015-2016"],"prefix":"10.26633","volume":"43","author":[{"given":"Ang\u00e9lica","family":"Medina","sequence":"first","affiliation":[{"name":"Programa Nacional de Control de la Tuberculosis, Ministerio de Salud P\u00fablica y Bienestar Social, Asunci\u00f3n, Paraguay"},{"name":"mediesc@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucelly","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Universidad Pontificia Bolivariana, Medell\u00edn, Colombia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Asunci\u00f3n, Asunci\u00f3n, Paraguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarita","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Programa Nacional de Control de la Tuberculosis, Ministerio de Salud P\u00fablica y Bienestar Social, Asunci\u00f3n, Paraguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Organizaci\u00f3n Panamericana de la Salud\/Organizaci\u00f3n Mundial de la Salud, Washington D.C., Estados Unidos de Am\u00e9rica."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","unstructured":"World Health Organization. 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