{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:18Z","timestamp":1788412698597,"version":"build-2803163510"},"reference-count":28,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,19]]},"abstract":"<p><bold>Introduction:<\/bold>This proof-of-concept study aims to demonstrate that quantitative texture analysis of magnetic resonance imaging (MRI) of orbital tumours can produce a unique footprint as an adjunct to histology and as a reference guide.<\/p><p><bold>Methods:<\/bold>\u2018MaZda\u2019 texture analysis software programme version 4.6 and MedCalc software (18.10.2) were used for data procuring and analysis. The following statistical analyses were performed: analysis of variance (ANOVA) to compare histogram means; Wilcoxon signed rank sum test to compare intra-lesion variability; Mann-Whitney U test to compare inter-lesion feature differences; area under curve to test sensitivity and specificity in differentiating abnormal from normal tissue; and Fisher\u2019s coefficient and linear discriminant analysis to reduce data vector dimensions.<\/p><p><bold>Results:<\/bold>Thirteen cases were assessed. Eleven cases were imaged with similar protocols. The software produced characteristic histograms and other quantitative parameters for a variety of orbital pathologies. The mean of histograms differed significantly between pathologies as well as other texture features and there were significant minimal misclassifications on inter-tumour analysis. Though the test showed 100% sensitivity in detecting abnormal tissues, it was not specific in differentiating some of the adnexal normal tissues from certain types of orbital tumours.<\/p><p><bold>Conclusions:<\/bold>This proof-of-concept study confirms that the non-invasive classification of orbital tumours is achievable. Further studies are needed to create a larger reference framework.<\/p>","DOI":"10.26633\/rpsp.2019.24","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T01:38:32Z","timestamp":1549589912000},"page":"1","source":"Crossref","is-referenced-by-count":16,"title":["S\u00edndrome cong\u00eanita do v\u00edrus Zika: perfil sociodemogr\u00e1fico das m\u00e3es"],"prefix":"10.26633","volume":"43","author":[{"given":"Paula de Souza Silva","family":"Freitas","sequence":"first","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade Coletiva, Vit\u00f3ria (ES), Brasil."},{"name":"Ethel Leonor Noia Maciel, ethel .maciel@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella Barreto","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade Coletiva, Vit\u00f3ria (ES), Brasil."},{"name":"Ethel Leonor Noia Maciel, ethel .maciel@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helaine Jacinta Salvador","family":"Mocelin","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade Coletiva, Vit\u00f3ria (ES), Brasil."},{"name":"Ethel Leonor Noia Maciel, ethel .maciel@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Carolina Xavier","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Departamento de Ci\u00eancias da Sa\u00fade, S\u00e3o Mateus (ES), Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Nascimento do","family":"Prado","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade Coletiva, Vit\u00f3ria (ES), Brasil."},{"name":"Ethel Leonor Noia Maciel, ethel .maciel@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Maia Martins","family":"Sales","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Laborat\u00f3rio de Epidemiologia (LabEpi UFES), Vit\u00f3ria (ES), Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Perez","sequence":"additional","affiliation":[{"name":"Pan American Health Organization (PAHO), Communicable Diseases and Environmental Determinants of Health Department, Washington (DC), Estados Unidos."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda Coelho de Azevedo","family":"Bussinger","sequence":"additional","affiliation":[{"name":"Faculdade de Direito de Vit\u00f3ria (FDV), Programa de P\u00f3s-Gradua\u00e7\u00e3o em Direito, Vit\u00f3ria (ES), Brasil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel Leonor Noia","family":"Maciel","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo (UFES), Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade Coletiva, Vit\u00f3ria (ES), Brasil."},{"name":"Ethel Leonor Noia Maciel, ethel .maciel@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11167","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Wikan N, Smith DR. 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