{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:40:47Z","timestamp":1771022447491,"version":"3.50.1"},"reference-count":29,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,2]]},"abstract":"<p><bold>Objetivo.<\/bold> Descrever o perfil cl\u00ednico-epidemiol\u00f3gico dos casos confirmados de microcefalia e\/ou altera\u00e7\u00f5es do sistema nervoso central (SNC) relacionadas a infec\u00e7\u00e3o cong\u00eanita pelo v\u00edrus Zika e outras etiologias infecciosas no estado do Rio de Janeiro no per\u00edodo de novembro de 2015 a julho de 2017.<\/p>\n<p><bold>M\u00e9todos.<\/bold> Realizou-se um estudo transversal de 298 casos (conforme defini\u00e7\u00e3o do Minist\u00e9rio da Sa\u00fade) notificados \u00e0 Secretaria de Estado de Sa\u00fade do Rio de Janeiro no per\u00edodo estudado. Analisaram-se vari\u00e1veis demogr\u00e1ficas, epidemiol\u00f3gicas, cl\u00ednicas, radiol\u00f3gicas e laboratoriais, com an\u00e1lise estat\u00edstica descritiva bivariada e m\u00faltipla por regress\u00e3o log\u00edstica para estudo de fatores associados ao \u00f3bito.<\/p>\n<p><bold>Resultados.<\/bold> A idade mediana das m\u00e3es foi 24 anos; 30,9% relataram febre, e 64,8%, exantema \u00e0 gesta\u00e7\u00e3o. A mediana do per\u00edmetro cef\u00e1lico ao nascer foi 29 cm e a do peso foi 2 635 g. O diagn\u00f3stico etiol\u00f3gico foi de Zika cong\u00eanita em 46,0%; de s\u00edfilis, toxoplasmose, rub\u00e9ola, citomegalov\u00edrus e v\u00edrus herpes simplex (STORCH) em 13,8%, com predom\u00ednio da s\u00edfilis; e de agente infeccioso n\u00e3o definido em 40,3%. Altera\u00e7\u00f5es do SNC diferentes de microcefalia foram descritas em 88,3%, predominando calcifica\u00e7\u00f5es cerebrais, ventriculomegalia e atrofia cerebral. A letalidade total foi 7,0%, sendo 19,0% nos casos de Zika confirmada laboratorialmente e 22,2% nos de toxoplasmose. Na an\u00e1lise m\u00faltipla, o peso ao nascer foi o principal preditor de \u00f3bito.<\/p>\n<p><bold>Conclus\u00f5es.<\/bold> Apesar da epidemia de Zika, 13,8% dos casos foram por STORCH. A letalidade e a elevada ocorr\u00eancia de malforma\u00e7\u00f5es neurol\u00f3gicas al\u00e9m da microcefalia mostram a gravidade da infec\u00e7\u00e3o, com impacto nas fam\u00edlias e no sistema de sa\u00fade.<\/p>","DOI":"10.26633\/rpsp.2020.151","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T16:36:01Z","timestamp":1604162161000},"page":"1","source":"Crossref","is-referenced-by-count":6,"title":["Microcefalia e altera\u00e7\u00f5es do sistema nervoso central relacionadas \u00e0 infec\u00e7\u00e3o cong\u00eanita pelo v\u00edrus Zika e outras etiologias infecciosas no estado do Rio de Janeiro: estudo transversal, 2015 a 2017"],"prefix":"10.26633","volume":"44","author":[{"given":"Claudia Caminha","family":"Escosteguy","sequence":"first","affiliation":[{"name":"Hospital Federal dos Servidores do Estado, Servi\u00e7o de Epidemiologia, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Escosteguy Medronho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Coelho","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Dalsenter Romano","family":"da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Andrade","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Beatriz","family":"Machado","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri Sousa","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Cristina","family":"de Carvalho Cardoso","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Sa\u00fade do Rio de Janeiro, Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jos\u00e9 Ledo Alves","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Rio de Janeiro (RJ), Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"de Andrade Medronho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Instituto de Estudos em Sa\u00fade, Rio de Janeiro (RJ), Brasil."},{"name":"robertoamedronho@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Plourde AR, Bloch EM. 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Acessado em 01\/09\/2019."}],"container-title":["Revista Panamericana de Salud P\u00fablica"],"original-title":[],"language":"pt","link":[{"URL":"https:\/\/iris.paho.org\/bitstream\/handle\/10665.2\/52939\/v44e1512020.pdf?sequence=1&isAllowed=y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T16:36:38Z","timestamp":1604162198000},"score":1,"resource":{"primary":{"URL":"https:\/\/iris.paho.org\/handle\/10665.2\/52939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":29,"alternative-id":["RPSP.2020.151"],"URL":"https:\/\/doi.org\/10.26633\/rpsp.2020.151","relation":{},"ISSN":["1020-4989","1680-5348"],"issn-type":[{"value":"1020-4989","type":"print"},{"value":"1680-5348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]}}}