{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:43:15Z","timestamp":1761129795642},"reference-count":20,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,23]]},"abstract":"<p><bold>Objetivo.<\/bold>El objetivo es presentar los resultados del Programa Latinoamericano de Aseguramiento de la Calidad en Bacteriolog\u00eda y Resistencia a los Antimicrobianos (LA-EQAS) entre 2000 y 2018 y la evoluci\u00f3n en la detecci\u00f3n de mecanismos de resistencia de impacto cl\u00ednico.<\/p><p><bold>M\u00e9todos.<\/bold>Los Laboratorios Nacionales de Referencia (LNR) participantes recibieron 25 encuestas con 10 cepas cada una, representando un total de 86 especies bacterianas y 40 mecanismos de resistencia. Para evaluar el desempe\u00f1o de los LNR, se analizaron cinco indicadores: identificaci\u00f3n bacteriana, interpretaci\u00f3n de las pruebas de sensibilidad, rangos de las zonas de inhibici\u00f3n aceptables, mecanismo de resistencia inferido, y tiempo de demora en la respuesta.<\/p><p><bold>Resultados.<\/bold>La concordancia media fue 82,6% (rango: 74-95%) en la identificaci\u00f3n bacteriana, 93,3% (85-98%) en la interpretaci\u00f3n de las pruebas de sensibilidad, 84,6% (70-94%) en las zonas de inhibici\u00f3n, 82,5% (73-96%) en el mecanismo de resistencia inferido, y la demora en la respuesta, 34 d\u00edas. Se observ\u00f3 una mejora en la detecci\u00f3n de mecanismos de relevancia cl\u00ednica como resistencia a meticilina, macr\u00f3lidos y glucop\u00e9ptidos en cocos gram positivos, y betalactamasas de espectro extendido, AmpC plasm\u00eddico y carbapenemasas en bacilos gram negativos.<\/p><p><bold>Conclusiones.<\/bold>El LA-EQAS es una excelente herramienta para la mejora continua de la calidad en el diagn\u00f3stico de las infecciones por microorganismos multirresistentes en los LNR de Am\u00e9rica Latina.<\/p>","DOI":"10.26633\/rpsp.2020.42","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T21:57:50Z","timestamp":1600379870000},"page":"1","source":"Crossref","is-referenced-by-count":1,"title":["Evoluci\u00f3n del desempe\u00f1o de Laboratorios de Referencia de Am\u00e9rica Latina en la detecci\u00f3n de mecanismos de resistencia a los antimicrobianos"],"prefix":"10.26633","volume":"44","author":[{"given":"Paula","family":"Gagetti","sequence":"first","affiliation":[{"name":"Servicio Antimicrobianos, Laboratorio Nacional\/Regional de Referencia en Resistencia a los Antimicrobianos, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Pasteran","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Laboratorio Nacional\/Regional de Referencia en Resistencia a los Antimicrobianos, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ceriana","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Laboratorio Nacional\/Regional de Referencia en Resistencia a los Antimicrobianos, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Prieto","sequence":"additional","affiliation":[{"name":"Servicio Bacteriolog\u00eda Especial, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Servicio Bacteriolog\u00eda Especial, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Tuduri","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Laboratorio Nacional\/Regional de Referencia en Resistencia a los Antimicrobianos, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nienke","family":"Bruinsma","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Program, Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization, Washington, DC, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Galas","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Program, Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization, Washington, DC, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Ram\u00f3n-Pardo","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Program, Communicable Diseases and Environmental Determinants of Health, Pan American Health Organization, Washington, DC, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Corso","sequence":"additional","affiliation":[{"name":"acorso@anlis.gob.ar"},{"name":"Servicio Antimicrobianos, Laboratorio Nacional\/Regional de Referencia en Resistencia a los Antimicrobianos, INEI-ANLIS \u201cDr. Carlos G. Malbr\u00e1n\u201d, Buenos Aires, Argentina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","unstructured":"Interagency Coordination Group on Antimicrobial Resistance (IACG). Draft IACG recommendations for public discussion 290119. Geneva: IACG; 2019. Disponible en: https:\/\/www.who.int\/antimicrobial-resistance\/interagency-coordination-group\/Draft_IACG_recommendations_for_public_discussion_290119.pdf?ua=1 Acceso el 27 de febrero de 2020."},{"key":"ref2","unstructured":"World Health Organization. Global Action Plan on Antimicrobial Resistance, 2015. Geneva: WHO; 2015. Disponible en: https:\/\/www.who.int\/antimicrobial-resistance\/global-action-plan\/en\/ Acceso el 27 de febrero de 2020."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Ashley EA, Recht J, Chua A, Dance D, Dhorda M, Thomaset NV, et al. 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