{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T13:54:09Z","timestamp":1674482049666},"reference-count":35,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,26]]},"abstract":"<p><bold>Objetivo.<\/bold> Comparar las propiedades diagn\u00f3sticas de cinco definiciones de caso sospechoso de COVID-19 utilizadas o propuestas en Chile durante los primeros ocho meses de la pandemia.<\/p>\n<p><bold>M\u00e9todos.<\/bold> Se analizaron las propiedades diagn\u00f3sticas (sensibilidad, especificidad, y valores predictivos positivo y negativo) de tres definiciones de caso sospechoso de COVID-19 utilizadas en Chile entre marzo y octubre del 2020, y dos propuestas de definici\u00f3n alternativas. La muestra fue de 2 019 personas con resultados conocidos a la prueba de la reacci\u00f3n en cadena de la polimerasa (PCR) para SARS-CoV-2. Para elaborar el criterio 5 se aplic\u00f3 una regresi\u00f3n log\u00edstica escalonada (<italic>stepwise<\/italic>) optimizando los valores de sensibilidad y especificidad. Se explor\u00f3 la asociaci\u00f3n de variables demogr\u00e1ficas, s\u00edntomas y signos con la positividad a la PCR mediante regresi\u00f3n log\u00edstica multifactorial. Se analizaron diferentes escenarios de positividad y se compararon las curvas ROC.<\/p>\n<p><bold>Resultados.<\/bold> La presencia de anosmia (OR = 8,00; IC95%: 5,34\u201311,99) y fiebre (OR = 2,15; IC95%: 1,28\u20133,59) y el haber tenido contacto estrecho previo con una persona enferma de COVID-19 (OR = 2,89; IC95%: 2,16\u20133,87) se asociaron con un resultado positivo de la PCR. Seg\u00fan el an\u00e1lisis de las curvas ROC, el criterio 5 tuvo la mayor capacidad de discriminaci\u00f3n, aunque sin diferencias significativas con los otros cuatro criterios.<\/p>\n<p><bold>Conclusiones.<\/bold> El criterio 5 \u2014basado en la anosmia, el contacto estrecho con personas enfermas de COVID-19 y la fiebre como elementos \u00fanicos suficientes\u2014 tuvo la mayor sensibilidad para identificar los casos sospechosos de COVID-19, aspecto fundamental para controlar la propagaci\u00f3n de la pandemia.<\/p>","DOI":"10.26633\/rpsp.2021.14","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T08:15:26Z","timestamp":1614240926000},"page":"1","source":"Crossref","is-referenced-by-count":2,"title":["Propiedades diagn\u00f3sticas de las definiciones de caso sospechoso de COVID-19 en Chile, 2020"],"prefix":"10.26633","volume":"45","author":[{"given":"Josefina","family":"Aubert","sequence":"first","affiliation":[{"name":"Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Monsalves","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Santiago, Chile."},{"name":"maria.monsalves@uss.cl"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Francisca","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena S.","family":"Rotarou","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Gajardo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias para el Cuidado de la Salud, Universidad San Sebasti\u00e1n, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Programa de Epidemiolog\u00eda, Escuela de Salud P\u00fablica, Universidad de Chile, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Paz","family":"Bertoglia","sequence":"additional","affiliation":[{"name":"Unidad de Nutrici\u00f3n de Poblaciones, Escuela de Salud P\u00fablica, Universidad de Chile, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Programa de Pol\u00edticas, Sistemas y Gesti\u00f3n en Salud, Escuela de Salud P\u00fablica, Universidad de Chile, Santiago, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3bal","family":"Cuadrado","sequence":"additional","affiliation":[{"name":"Departamento de Salud P\u00fablica-CIGES, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Zhu N, Zhang D, Wang W, Deng JW, Zheng L, Zhu HH, et al. 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