{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T20:01:03Z","timestamp":1787342463846,"version":"build-2736575974"},"reference-count":24,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,28]]},"abstract":"<sec>\n<title>Introducci\u00f3n.<\/title>\n<p>Las leishmaniasis contin\u00faan siendo enfermedades infecciosas desatendidas de gran importancia, ya que afectan principalmente a las personas m\u00e1s pobres y con menor acceso a los servicios de salud. En la Regi\u00f3n de las Am\u00e9ricas constituyen un problema de salud p\u00fablica debido a su magnitud, amplia distribuci\u00f3n geogr\u00e1fica y morbimortalidad.<\/p>\n<\/sec>\n<sec>\n<title>Objetivo.<\/title>\n<p>Sintetizar las recomendaciones incluidas en las <italic>Directrices para el tratamiento de las leishmaniasis en la Regi\u00f3n de las Am\u00e9ricas<\/italic> publicadas por la Organizaci\u00f3n Panamericana de la Salud\/Organizaci\u00f3n Mundial de la Salud, con el fin de brindar un manejo adecuado de los pacientes con diagn\u00f3stico de leishmaniasis, reducir las complicaciones cl\u00ednicas y muertes causadas por la toxicidad de los medicamentos as\u00ed como la letalidad de la leishmaniasis visceral, y abordar aspectos claves de su implementaci\u00f3n.<\/p>\n<\/sec>\n<sec>\n<title>M\u00e9todos.<\/title>\n<p>Se llev\u00f3 a cabo una s\u00edntesis de las directrices y sus recomendaciones. Adem\u00e1s, se realiz\u00f3 una b\u00fasqueda sistem\u00e1tica en PubMed, Lilacs, Health Systems Evidence, Epistemonikos y literatura gris de otros estudios desarrollados en la Regi\u00f3n de las Am\u00e9ricas con el fin de identificar barreras, facilitadores y estrategias de implementaci\u00f3n.<\/p>\n<\/sec>\n<sec>\n<title>Resultados.<\/title>\n<p>Se presentan recomendaciones que abordan el tratamiento farmacol\u00f3gico de pacientes con diagn\u00f3stico de leishmaniasis cut\u00e1nea, mucosa y visceral en las Am\u00e9ricas, as\u00ed como para el manejo y la profilaxis secundaria en pacientes coinfectados con leishmaniasis visceral y VIH y pacientes con otras enfermedades que causan inmunosupresi\u00f3n.<\/p>\n<\/sec>\n<sec>\n<title>Conclusiones.<\/title>\n<p>Las recomendaciones buscan proveer conocimiento sobre el manejo de las leishmaniasis para entes gubernamentales y profesionales de la salud que atienden pacientes con la enfermedad en las Am\u00e9ricas. Se presentan barreras relacionadas con los recursos humanos, el conocimiento de las directrices, insumos, costos, acceso y barreras de los pacientes, as\u00ed como facilitadores y estrategias de apoyo a la implementaci\u00f3n.<\/p>\n<\/sec>","DOI":"10.26633\/rpsp.2023.43","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T14:07:43Z","timestamp":1682604463000},"page":"1","source":"Crossref","is-referenced-by-count":29,"title":["S\u00edntesis de evidencia y recomendaciones: directrices para el tratamiento de las leishmaniasis en la Regi\u00f3n de las Am\u00e9ricas"],"prefix":"10.26633","volume":"47","author":[{"family":"Organizaci\u00f3n Panamericana de la Salud","sequence":"first","affiliation":[{"name":"Organizaci\u00f3n Panamericana de la Salud, Washington, D.C., Estados Unidos de Am\u00e9rica."},{"name":"reveizl@paho.org"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11167","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Alvar J, V\u00e9lez ID, Bern C, Herrero M, Desjeux P, Cano J, et al. 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