{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:50:41Z","timestamp":1793908241665,"version":"4.8.0"},"reference-count":26,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<title>ABSTRACT<\/title>\n                  <sec>\n                    <title>Objective.<\/title>\n                    <p>To compare sociodemographic and clinical characteristics and the outcome severity between confirmed cases of Oropouche fever and dengue in the state of Esp\u00edrito Santo, Brazil.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Methods.<\/title>\n                    <p>A cross-sectional study used secondary data from the state health surveillance system of Esp\u00edrito Santo, 2024\u20132025. The study includes laboratory-confirmed cases of Oropouche fever and dengue. The authors calculated absolute and relative frequencies of variables. Pearson\u2019s chi-square and Fisher\u2019s exact tests assessed differences. Firth\u2019s penalized logistic regression estimated odds ratios (OR) for severe manifestations and death, with 95% confidence intervals (95% CI).<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Results.<\/title>\n                    <p>A total of 12 135 OF cases and 18 018 dengue cases were confirmed. Compared with dengue cases, Oropouche fever was more prevalent among males (53.5%), white individuals (56.3%), and residents of rural and peri-urban areas (52.1%). Fever (84.5% vs. 78.7%), headache (83.9% vs. 72.1%), and myalgia (76.5% vs. 67.5%) were the most common symptoms in both groups, with significantly higher proportions among Oropouche fever cases. Dengue cases showed higher odds of progressing to severe disease (OR 15.35; 95% CI 10.60\u201322.23) and death (OR 2.09; 95% CI 1.10\u20133.98).<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Conclusion.<\/title>\n                    <p>Oropouche fever and dengue presented overlapping clinical profiles; however, Oropouche fever was more frequent in rural and peri-urban areas. Dengue was associated with greater severity and lethality. These findings underscore the importance of surveillance to support strategies for monitoring, clinical management, and control, while accounting for the distinct epidemiological and clinical profiles of Oropouche fever and dengue.<\/p>\n                  <\/sec>","DOI":"10.26633\/rpsp.2025.127","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:54:57Z","timestamp":1766584497000},"page":"1","source":"Crossref","is-referenced-by-count":3,"title":["Sociodemographic characteristics, clinical manifestations, and concurrent outcomes of Oropouche fever and dengue in Esp\u00edrito Santo, Brazil"],"prefix":"10.26633","volume":"49","author":[{"given":"Jo\u00e3o Paulo","family":"Cola","sequence":"first","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."},{"name":"joaopaulocola@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Nascimento","family":"do Prado","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otavio T.","family":"Ranzani","sequence":"additional","affiliation":[{"name":"DataHealth Lab, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Brioschi dos Santos","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Silva","family":"Freire","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Lubiana","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Endlich da Silva","family":"Dela Costa","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Bertazo","family":"Del Carro","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesliane de Amorim","family":"Lacerda Coelho","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia","family":"Lepaus Thomas","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dijoce","family":"Prates Bezerra","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlei","family":"Amaral Cardoso","sequence":"additional","affiliation":[{"name":"Secretaria de Estado da Sa\u00fade do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Espinosa Miranda","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel Leonor","family":"Noia Maciel","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Creuza Rachel","family":"Vicente","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo, Esp\u00edrito Santo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11167","reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Wesselmann KM, Postigo-Hidalgo I, Pezzi L, de Oliveira-Filho EF, Fischer C, de Lamballerie X, et al. 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