{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:05:41Z","timestamp":1772820341790,"version":"3.50.1"},"reference-count":33,"publisher":"Pan American Health Organization","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,6]]},"abstract":"<title>RESUMEN<\/title>\n                  <sec>\n                    <title>Objetivo.<\/title>\n                    <p>Estimar la prevalencia de la infecci\u00f3n por HTLV-1 en los familiares de casos \u00edndice positivos referidos a un centro especializado en el Per\u00fa, as\u00ed como su distribuci\u00f3n seg\u00fan el tipo de parentesco y la presencia de enfermedades asociadas a la infecci\u00f3n.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>M\u00e9todos.<\/title>\n                    <p>Se realiz\u00f3 un estudio retrospectivo mediante la revisi\u00f3n de los registros de la Unidad de Investigaci\u00f3n en HTLV-1 del Instituto de Medicina Tropical Alexander von Humboldt, Per\u00fa. Se identificaron los casos \u00edndices, definidos como el primer individuo positivo en cada grupo familiar, y se determin\u00f3 la prevalencia de HTLV-1 en sus familiares directos (padre, madre, hermanos, hijos y parejas) mediante un estimador por conglomerado.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Resultados.<\/title>\n                    <p>Se estudi\u00f3 un total de 1 255 casos \u00edndice y 3 431 familiares. La frecuencia de familiares estudiados fue de 30,30%. La prevalencia de HTLV-1 en familiares fue de 36,43% (IC 95%: 34,67\u201338,23%). Las frecuencias espec\u00edficas fueron: 63,30% en madres, 52,33% en padres, 32,65% en hermanos, 22,84% en hijos y 57,19% en parejas.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Conclusi\u00f3n.<\/title>\n                    <p>La prevalencia encontrada sugiere la existencia de transmisi\u00f3n intrafamiliar en la cohorte, por lo que resulta necesario ampliar los estudios para identificar factores de riesgo asociados. Los resultados enfatizan la necesidad de implementar una nueva estrategia de tamizaje en el pa\u00eds, en la cual se estudie a los familiares cercanos de todos los casos positivos para HTLV-1, lo cual debe reflejarse en las pol\u00edticas de salud p\u00fablica.<\/p>\n                  <\/sec>","DOI":"10.26633\/rpsp.2026.14","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:59:02Z","timestamp":1772798342000},"page":"1","source":"Crossref","is-referenced-by-count":0,"title":["Prevalencia familiar de infecci\u00f3n por HTLV-1 a partir de un caso \u00edndice en Per\u00fa"],"prefix":"10.26633","volume":"50","author":[{"given":"Maria Pia","family":"Bobadilla-Chuquiure","sequence":"first","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Quiliche-Ar\u00e9valo","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mej\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Cayetano Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Garrido-Pinz\u00e1s","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dyana","family":"Guardia","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Gonzales-Lagos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Gotuzzo","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa."},{"name":"eduardo.gotuzzo@upch.pe"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11167","reference":[{"key":"ref1","unstructured":"Eusebio-Ponce E, Anguita E, Paulino-Ramirez R, Candel FJ. 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