{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:23:11Z","timestamp":1758054191801,"version":"3.44.0"},"reference-count":0,"publisher":"Pasifika Medical Association Group","issue":"1622","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NZMJ"],"abstract":"<jats:p>aim: To provide a balanced account of psilocybin treatment of depression for expectations to be appropriately set.\nmethod: Review and discussion of key psilocybin efficacy studies. Reporting of side effects and risk of harm with psychedelic treatments.\nComparisons and contrasts with ketamine studies of treatment-resistant depression (TRD).\nresult: Early psilocybin studies offer promise but expectation bias and functional unblinding are factors in the treatment response.\nPsilocybin is generally well tolerated but side effects are often not systematically reported, and some recipients may experience harm.\nThe ketamine research has similar methodological considerations, but the weight of positive evidence is stronger for a treatmentresistant\ngroup.\nconclusion: The evidence for psilocybin treatment of depression is insufficient to press for wider availability and use.<\/jats:p>","DOI":"10.26635\/6965.7138","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T01:31:56Z","timestamp":1757899916000},"page":"94-97","source":"Crossref","is-referenced-by-count":0,"title":["Reappraisal of the hype and hope offered by psilocybin treatment of depression"],"prefix":"10.26635","volume":"138","author":[{"given":"Ben","family":"Beaglehole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenni","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11177","published-online":{"date-parts":[[2025,9,19]]},"container-title":["New Zealand Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T01:31:57Z","timestamp":1757899917000},"score":1,"resource":{"primary":{"URL":"https:\/\/nzmj.org.nz\/journal\/vol-138-no-1622\/reappraisal-of-the-hype-and-hope-offered-by-psilocybin-treatment-of-depression"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":0,"journal-issue":{"issue":"1622","published-online":{"date-parts":[[2025,9,19]]}},"URL":"https:\/\/doi.org\/10.26635\/6965.7138","relation":{},"ISSN":["1175-8716"],"issn-type":[{"value":"1175-8716","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]}}}