{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:13:54Z","timestamp":1788430434486,"version":"build-2803163510"},"reference-count":0,"publisher":"World Health Organization Regional Office for the Eastern Mediterranean (WHO\/EMRO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["East Mediterr Health J."],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:p>Background: Diabetes is widely studied in Algeria, but its associated health-related quality-of-life remains underexplored.\nAim: To assess health-related quality-of-life and predictors of reduced health-related quality-of-life among Algerian patients with type 1 or type 2 diabetes mellitus receiving insulin therapy.\nMethods: From July 2019 to February 2020, we interviewed 400 confirmed diabetes patients who had been receiving insulin treatment for \u22656 months at the Internal Medicine Department of Tlemcen University Hospital and outpatient clinics in Agadir and Boudghen. We analysed the data using SPSS version 25 and used independent t test or one-way analysis of variance to analyse differences in EuroQol 5-Dimension 5-Level index values and EuroQol visual analogue scale scores across subgroups. We used \u03c72 test to compare the differences in reported problems across EuroQol 5-Dimension 5-Level dimensions among the subgroups. P &lt; 0.05 was considered statistically significant.\nResults: The mean EuroQol 5-Dimension 5-Level index value was 0.595 \u00b1 0.23, and mean EuroQol visual analogue scale score was 60.51 \u00b1 20.45. Multiple linear regression associated \u22654 insulin injections per day with reduced healthrelated quality-of-life, and this relationship was strong and persistent even after controlling for clinical factors such as haemoglobin A1c levels. It affected mostly the psychological dimensions.\nConclusion: Our finding shows moderate health-related quality-of-life and a significant psychological burden among insulin-treated patients. It identifies high insulin injection frequency as a key predictor of reduced health-related qualityof-life, independent of glycaemic control. We recommend multidimensional measures, based on mental health support and education, to mitigate treatment burden beyond traditional diabetes management.<\/jats:p>","DOI":"10.26719\/2026.32.8.505","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:19:46Z","timestamp":1788427186000},"page":"505-512","source":"Crossref","is-referenced-by-count":0,"title":["High insulin injection frequency is a key independent predictor of health-related quality-of-life in diabetic patients in Algeria"],"prefix":"10.26719","volume":"32","author":[{"given":"Mohammed Nassim Boukli","family":"Hacene","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, Abou-Bekr Belkaid University, Algeria; Department of Biochemistry, Dr Tidjani Damerdji University Hospital, Algeria; Cancer Research Laboratory, Abou-Bekr Belkaid University, Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Youcef","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, Abou-Bekr Belkaid University, Algeria; Department of Biochemistry, Dr Tidjani Damerdji University Hospital, Algeria; Cancer Research Laboratory, Abou-Bekr Belkaid University, Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Saker","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology, Pathophysiology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaid University, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Brikci-Nigassa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Dr Tidjani Damerdji University Hospital, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Lounici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr Tidjani Damerdji University Hospital, Abou- Bekr Belkaid University, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaouel","family":"Meguenni","sequence":"additional","affiliation":[{"name":"Cancer Research Laboratory, Abou-Bekr Belkaid University, Algeria; Department of Epidemiology, Dr Tidjani Damerdji University Hospital, Abou-Bekr Belkaid University, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11263","published-online":{"date-parts":[[2026,9,3]]},"container-title":["Eastern Mediterranean Health Journal"],"original-title":[],"link":[{"URL":"http:\/\/applications.emro.who.int\/EMHJ\/1020-3397-2026-3208-505-512-eng.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:19:46Z","timestamp":1788427186000},"score":1,"resource":{"primary":{"URL":"http:\/\/applications.emro.who.int\/EMHJ\/1020-3397-2026-3208-505-512-eng.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,9,3]]},"published-print":{"date-parts":[[2026,9,3]]}},"URL":"https:\/\/doi.org\/10.26719\/2026.32.8.505","relation":{},"ISSN":["1020-3397","1687-1634"],"issn-type":[{"value":"1020-3397","type":"print"},{"value":"1687-1634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]}}}