{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:33:31Z","timestamp":1773167611153,"version":"3.50.1"},"reference-count":0,"publisher":"World Health Organization Regional Office for the Eastern Mediterranean (WHO\/EMRO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["East Mediterr Health J."],"published-print":{"date-parts":[[2022,10,31]]},"abstract":"<jats:p>Background: There have been system inefficiencies in the profiling and management of female breast cancer in Alexandria, Egypt. Aims: To identify barriers to full implementation of international guidelines for the management of female breast cancer patients. Methods: Female breast cancer data were extracted from records of 3 public oncology services in Alexandria, Egypt, from 2007 to 2016 and analysed. Results: A total of 5236 of the available 7125 records were usable. Median age of the patients was 54 years, and the median duration of pre-diagnosis complaint was 3.1 months. Some 522 (31.5%) of the patients had a family history of cancer. For tumour stage, 2527 (55.2%) were early, 1717 (37.6%) were locally advanced, and 331 (7.2%) were at stage IV. Estrogen receptor, progesterone receptor, and HER2 were positive in 3869 (85%), 3545 (78%), and 461 (15.3%) patients, respectively. Chemotherapy started after a median 1.03 months. Adjuvant chemotherapy was given to 3667 (91.7 %) patients and neoadjuvant chemotherapy to 333 (8.3%); 3686 (92.1%) received anthracycline-based combination chemotherapy, and 3613 (86%) received hormonal treatment. One hundred and eighty of 317 eligible patients received Trastuzumab. Local and\/or distant recurrence was seen in 1109 (21.2%) patients. In nonmetastatic cases, median overall and disease-free survival were 149.1 and 77.1 months, respectively. In metastatic cases, median progression-free survival was 19.6 months. Conclusion: We observed defects in the record system, there was delay in diagnosis and treatment, and nonadherence to targeted therapy in many patients. Strengthening of national and hospital-based registries is needed in Alexandria, Egypt, with a robust patient navigation system and targeted information, education and communication strategies. Continuous outcomes monitoring and adaptation to implementation needs should be sustained.<\/jats:p>","DOI":"10.26719\/emhj.22.076","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T13:35:56Z","timestamp":1663594556000},"page":"725-732","source":"Crossref","is-referenced-by-count":10,"title":["Presentation and management of female breast cancer in Egypt"],"prefix":"10.26719","volume":"28","author":[{"given":"Yousri","family":"Rostom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah-Eldin","family":"Abdelmoneim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayera","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11263","published-online":{"date-parts":[[2022,10,31]]},"container-title":["Eastern Mediterranean Health Journal"],"original-title":[],"link":[{"URL":"https:\/\/applications.emro.who.int\/EMHJ\/V28\/10\/1020-3397-2022-2810-725-732-eng.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T11:56:14Z","timestamp":1667303774000},"score":1,"resource":{"primary":{"URL":"https:\/\/applications.emro.who.int\/EMHJ\/V28\/10\/1020-3397-2022-2810-725-732-eng.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,31]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10,31]]},"published-print":{"date-parts":[[2022,10,31]]}},"URL":"https:\/\/doi.org\/10.26719\/emhj.22.076","relation":{},"ISSN":["1020-3397","1687-1634"],"issn-type":[{"value":"1020-3397","type":"print"},{"value":"1687-1634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,31]]}}}