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Rosai J, and Sobin LH. Histological typing of tumours of the thymus. World Health Organization international histological classification of tumors. Second Edition. New York: 1999; Springer 1999; 2:65.","DOI":"10.1007\/978-3-642-60157-6"},{"key":"2","unstructured":"2. Travis WD, Brambilla E, Muller-Hermelink HK, and Harrys CC. World Health Organization classification of tumours. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: 2004; IARC Press."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Marino M, and Muller-Hermelink HK. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch Pathol Anat Histopathol 1985; 407:119-149.","DOI":"10.1007\/BF00737071"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Muller-Hermelink HK, and Marx A. Thymoma. Curr Opin Oncol 2000; 12:426-433.","DOI":"10.1097\/00001622-200009000-00007"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kondo K, and Monden Y. Thymoma and myasthenia gravis: a clinical study of 1,089 patients from Japan. Ann Thorac Surg 2005; 79:219-224.","DOI":"10.1016\/j.athoracsur.2004.06.090"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Lewis JE, Wick MR, Scheithauer BW, Bernatz PE, and Taylor WF. Thymoma. A clinicopathologic review. Cancer 1987; 60:2727-2743.","DOI":"10.1002\/1097-0142(19871201)60:11<2727::AID-CNCR2820601125>3.0.CO;2-D"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Okumura M, Ohta M, Tateyama H, Nakagawa K, Matsumura A et al. Masaoka A. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer 2002; 94:624-632.","DOI":"10.1002\/cncr.10226"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, and Duane DD. Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value. Neurology 1998; 51:933-939.","DOI":"10.1212\/WNL.51.4.933-a"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zhang GX, Xiao BG, Bakhiet M, van der Meide P, Wigzell H et al. Both CD4<SUP>+<\/SUP> and CD8<SUP>+<\/SUP> T cells are essential to induce experimental autoimmune myasthenia gravis. J Exp Med 1996; 184:349-356.","DOI":"10.1084\/jem.184.2.349"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Vincent A, and Willcox N. The role of T-cells in the initiation of autoantibody responses in thymoma patients. Pathol Res Pract 1999; 195:535-540.","DOI":"10.1016\/S0344-0338(99)80002-8"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Str&ouml;bel P, Helmreich M, Menioudakis G, Lewin SR, R&uuml;diger T et al. Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas. Blood 2002; 100:159-166.","DOI":"10.1182\/blood.V100.1.159"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, et al. A CD4<SUP>+<\/SUP> T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737-742.","DOI":"10.1038\/39614"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Levings MK, Sangregorio R, Galbiati F, Squadrone S, de Waal Malefyt R et al. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 2001; 166:5530-5539.","DOI":"10.4049\/jimmunol.166.9.5530"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Shevach EM. CD4<SUP>+<\/SUP> CD25<SUP>+<\/SUP> suppressor T cells: more questions than answers. 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Karube K, Aoki R, Sugita Y, Yoshida S, Nomura Y et al. The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia&frasl;lymphoma. Mod Pathol 2008; 21:617-625.","DOI":"10.1038\/modpathol.2008.25"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-1164.","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Fontenot JD, Gavin MA, and Rudensky AY. FoxP3 programs the development and function of CD4<SUP>+<\/SUP>CD25<SUP>+<\/SUP> regulatory T cells. Nat Immunol 2003; 4:330-336.","DOI":"10.1038\/ni904"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Hori S, and Sakaguchi S. 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Fattorossi A, Battaglia A, Buzzonetti A, Ciaraffa F, Scambia G et al. Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: effect of immunosuppressive treatment. Immunology 2005; 116:134-141.","DOI":"10.1111\/j.1365-2567.2005.02220.x"},{"key":"26","unstructured":"26. Wang HB, Zhang JB, and Chui LY. Identification of correlations between numbers of CD4<SUP>+<\/SUP>CD25<SUP>+<\/SUP> Tregs cells, levels of sera anti-AchR antibodies and transfer growth factor-beta in patients with myasthenia gravis [Article in Chinese]. Zhonghua Yi Xue Za Zhi 2008; 88:1036-1040."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Heldal AT, Eide GE, Romi F, Owe JF, and Gilhus NE. Repeated acetylcholine receptor antibody-concentrations and association to clinical myasthenia gravis development. PLos One 2014 Dec 2; 9:e114060.","DOI":"10.1371\/journal.pone.0114060"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S et al. Differential roles of epigenetic changes and FoxP3 expression in regulatory T cell-specific transcriptional regulation. Proc Natl Acad Sci U S A 2014; 111:5289-5294.","DOI":"10.1073\/pnas.1312717110"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Zhang Y, Wang HB, Chi LJ, and Wang WZ. The role of FoxP3<SUP>+<\/SUP> CD4<SUP>+<\/SUP>6CD25<SUP>hi<\/SUP> Tregs in the pathogenesis of myasthenia gravis. 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