{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:53:50Z","timestamp":1793274830144,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":3597,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    We used isolated equine digital arteries to study the vasodilatory mechanism of isoxsuprine, and fowl caecum preparations to investigate the affinity of the drug for \u03b2\u2010adrenoceptors. Isoxsuprine is a potent vasodilator of arterial smooth muscle that has been precontracted by an \u03b1\u2010adrenoceptoragonist such as noradrenaline (log EC\n                    <jats:sub>50<\/jats:sub>\n                    = \u20106.33 [\u20105.98; \u20106.68]). The present study indicates that its effect is due to \u03b1\u2010adrenoceptorblockade since: (1) aftera long lasting exposure to cumulative doses of isoxsuprine the vasoconstricting action of noradrenaline cannot be restored; (2) isoxsuprine does not promote relaxation on preparations precontracted by PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    ; (3) isoxsuprine shifts the dose\u2010response curve of noradrenaline to the right; and (4) its affinity (pK\n                    <jats:sub>B<\/jats:sub>\n                    = 6.90 [6.60; 7.20]) in this experiment is comparable to that in noradrenaline\u2010precontracted preparations and is 14 times lower than that of the selective \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    \u2010adrenergic antagonist prazosin [pK\n                    <jats:sub>B<\/jats:sub>\n                    = 8.04 (7.40; 8.68]).\n                  <\/jats:p>\n                  <jats:p>\n                    The affinity of isoxsuprine for \u03b2\u2010adrenoceptors was 100 times lower than that of isoprenaline when tested on fowl caecum. This preparation has a large \u03b2\u2010adrenoceptor and negligible \u03b1\u2010adrenoceptor population concerned with the control of smooth muscle motility. Our data suggest that the \u03b1\u2010mediated effect of isoxsuprine on horse arterial smooth muscle is due to higher affinity of the drug for \u03b1\u2010 than \u03b2\u2010adrenoceptors ratherthan low concentration orfunctionality of \u03b2\u2010sites at this site. According to these data, pure \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    \u2010agonists seem to be more profitable tools to determine vasodialtion of the arterial bed in horses legs.\n                  <\/jats:p>","DOI":"10.2746\/042516400777591543","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Affinity of isoxsuprine for adrenoreceptors in equine digital artery and implications for vasodilatory action"],"prefix":"10.1111","volume":"32","author":[{"given":"C.","family":"Belloli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Carcano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Arioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610130604"},{"key":"e_1_2_1_3_1","first-page":"541","article-title":"The pharmacology of catecholamines and their derivatives","volume":"13","author":"Ariens E.J.","year":"1963","journal-title":"Arzneimittel-Forsch."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1989.tb01075.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1985.tb00122.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod30.5.1117"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(99)00009-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(78)90231-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.129.19.427"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2885.1997.00078.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.2042-3306.1995.tb04996.x","article-title":"Characterization of \u03b2\u2010adrenoceptors in equine digital veins: implications of the modes of vasodilatory action of isoxsuprine","volume":"19","author":"Elliott J.","year":"1995","journal-title":"Equine vet. 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