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Normal articular cartilage appeared glossy and bluish\u2010white, was of normal thickness and showed no evidence of discolouration, fibrillation or other cartilage discontinuity. Slight discolouration and fibrillation or minor clefts of the cartilage were considered as moderate OA, whereas erosions of articular cartilage down to the subchondral bone were considered as cases of severe OA.\n                  <\/jats:p>\n                  <jats:p>\n                    Explant cultures of equine synovial membrane and articular cartilage released the local mediators, NO and PGE\n                    <jats:sub>2<\/jats:sub>\n                    , as well as detectable levels of NMP activity into culture media. Concentrations of NO were higherin articular cartilage explants compared to synovial membrane explants, whereas concentrations of PGE\n                    <jats:sub>2<\/jats:sub>\n                    were higher in synovial membrane explants. The NMPs with collagenolytic activities were similar in both explant cultures, whereas gelatinolytic activities were higherin synovial membrane explant cultures and caseinolytic activities were generally higher in articular cartilage explant cultures. Furthermore it was shown that concentrations or enzyme activities increased according to the severity of disease of the joints. Concentrations for NO, collagenolytic and gelatinolytic NMPs were relatively stable, whereas PGE\n                    <jats:sub>2<\/jats:sub>\n                    and caseinolytic NMP concentrations increased over time in culture.\n                  <\/jats:p>","DOI":"10.2746\/042516400777591598","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"140-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Spontaneous production of nitric oxide (NO), prostaglandin (PGE\n                    <sub>2<\/sub>\n                    ) and neutral metalloproteinases (NMPs) in media of explant cultures of equine synovial membrane and articular cartilage from normal and osteoarthritic joints"],"prefix":"10.1111","volume":"32","author":[{"given":"B.","family":"Von Rechenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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