{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:00:17Z","timestamp":1770217217935,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":2987,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Two of the most commonly isolated foal pathogens are\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Actinobacillus equuli.<\/jats:italic>\n                    The hypothesis tested in this study was that young foals carry a lower opsonic capacity for these bacteria compared to adult horses. A flow\u2010cytometric method for the phagocytosis of these by equine neutrophils was established. The opsonic capacity of serum from healthy foals from birth to age 6 weeks was evaluated and related to the concentrations of IgGa and IgGb. Phagocytosis of yeast was used as a control. Serum was required for phagocytosis, with higher concentrations for\n                    <jats:italic>E. coli<\/jats:italic>\n                    than for\n                    <jats:italic>A. equuli.<\/jats:italic>\n                    Ingestion of colostrum led to a significantly higher serum opsonic capacity. After that, there was no consistent age\u2010related trend for opsonic capacity for the different microbes. Foal serum showed similar or higher opsonisation of\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>A. equuli<\/jats:italic>\n                    compared to serum from mature individuals. During the studied period, the predominance among IgG subisotypes switched from IgGb to IgGa. Although the overall correlation between concentrations of IgG subisotypes and serum opsonic capacity was poor, sera with IgGb levels below 1.9 mg\/ml induced lower opsonisation of\n                    <jats:italic>E. coli<\/jats:italic>\n                    and yeast, but not of\n                    <jats:italic>A. equuli.<\/jats:italic>\n                    Complement activation was important for opsonisation of all tested microbes. The results of this study are significant to the understanding of a key immunological facet in the pathophysiology of equine neonatal septicaemia in clinical practice.\n                  <\/jats:p>","DOI":"10.2746\/042516401776249381","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"670-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Opsonic capacity of foal serum for the two neonatal pathogens\n                    <i>Escherichia coli<\/i>\n                    and\n                    <i>Actinobacillus equuli<\/i>"],"prefix":"10.1111","volume":"33","author":[{"given":"G.","family":"GR\u00d6NDAHL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"STERNBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"JENSEN\u2010WAERN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"JOHANNISSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"581","article-title":"Surface receptors on neutrophils and monocytes from immunodeficient and normal horses","volume":"28","author":"Banks K.","year":"1975","journal-title":"Immunol."},{"key":"e_1_2_1_3_1","first-page":"189","article-title":"The equine complement system (and its role in immunity)","volume":"1978","author":"Barta O.","year":"1976","journal-title":"J. equine Med. Surg."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2460\/ajvr.1972.33.04.741","article-title":"Postnatal development of bactericidal activity in serum from conventional and colostrum\u2010deprived calves","volume":"33","author":"Barta O.","year":"1972","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_5_1","volume-title":"[Foal Septicaemia \u2010 Bacterial Findings and Resistance Patterns in Sweden.]","author":"B\u00e5verud V.","year":"2001"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2460\/ajvr.1994.55.07.928","article-title":"Hemolytic complement activity and concentrations of its third component during maturation of the immune response in colostrum\u2010deprived foals","volume":"55","author":"Bernoco M.M.","year":"1994","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_7_1","first-page":"599","article-title":"Chemotactic and phagocytic function of peripheral blood polymorphonuclear leococytes in newborn foals","volume":"35","author":"Bernoco M.","year":"1987","journal-title":"J. Reprod. Fertil."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2460\/ajvr.1983.44.10.1923","article-title":"Phagocytosis and intracellular killing of the contagious equine metritis organism by equine neutrophils in genital secretions","volume":"44","author":"Bertram T.A.","year":"1983","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb03147.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11464.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(00)00149-5"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(98)00299-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00262-8"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050483"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(87)90096-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.2460\/ajvr.1993.54.06.878","article-title":"Linkage of serum resistance, aerobactin production and resistance to antimicrobial agents on conjugal plasmids in some strains of Escherichia coli isolated from septic foals","volume":"54","author":"Hirsch D.C.","year":"1993","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/BF03547669","article-title":"Flow\u2010cytometric investigations of the phagocytic capacities of equine granulocytes","volume":"36","author":"Johannisson A.","year":"1995","journal-title":"Acta vet. Scand."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165.2.290"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1988.49.03.295"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(87)90016-X"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2460\/ajvr.1983.44.05.747","article-title":"Changes of complement values in calves during the first month of life","volume":"44","author":"Mueller R.","year":"1983","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(00)00067-X"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1996.tb10006.x"},{"key":"e_1_2_1_24_1","first-page":"71","article-title":"Inhibition of Escherichia coli by bovine colostrum and post\u2010colostral milk. I. Complement\u2010mediated bactericidal activity of antibodies to a serum susceptible strain of E. coli of the serotype O 111","volume":"28","author":"Reiter B.","year":"1975","journal-title":"Immunol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0147-9571(79)90027-4"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(93)90039-7"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1993.tb02946.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.143.9.254"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1099"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(97)00188-0"},{"key":"e_1_2_1_31_1","unstructured":"Sternberg S.(1999)Studies on equineActinobacillusspp.PhD Thesis.Swedish University of Agricultural Sciences. Acta. Universitasis Agriculturae Sueciae: Veterinaria .67."},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/BF03547581","article-title":"Phagocytosis induced by yeast cells in canine granulocytes: A methodological study","volume":"31","author":"Trowald\u2010Wigh G.","year":"1990","journal-title":"Acta vet. Scand."},{"key":"e_1_2_1_33_1","first-page":"105","article-title":"Intestinal absorption of colostral lymphocytes in newborn lambs and their role in the development of immune status","volume":"43","author":"Tuboly S.","year":"1995","journal-title":"Acta Vet. Hung."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1991.tb03763.x"},{"key":"e_1_2_1_35_1","first-page":"1","article-title":"Immunomodulating effects of intestinal absorbed maternal colostral leukocytes by neonatal pigs","volume":"57","author":"Williams P.P.","year":"1993","journal-title":"Can. J. vet. Res."},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2460\/javma.1989.195.12.1759","article-title":"Comparison of bacteriologic culture of blood and necropsy specimens for determining the cause of foal septicemia: 47 cases (1978\u20131987)","volume":"195","author":"Wilson W.D.","year":"1989","journal-title":"J. Am. vet. med. Ass."}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2746%2F042516401776249381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.2746\/042516401776249381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:47:45Z","timestamp":1762091265000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.2746\/042516401776249381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.2746\/042516401776249381"],"URL":"https:\/\/doi.org\/10.2746\/042516401776249381","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"2010-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}