{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:30:54Z","timestamp":1770219054584,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":2987,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The purpose of this study was to examine the effects of an external nasal strip (NS), frusemide (FR) and a combination of the 2 treatments (NS + FR) on exercise\u2010induced pulmonary haemorrhage (EIPH) in Thoroughbred horses. It was hypothesised that both the NS and FR would attenuate EIPH as assessed by red blood cell count in bronchoalveolar lavage fluid. In random order, 8 horses completed each of 4 sprint exercise tests on a treadmill: 1) NS; 2) FR (0.5 mg\/kg bwt i.v., 4 h pre\u2010exercise); 3) NS + FR; and 4) control (C; no treatment). After a 5 min warm\u2010up (4.5 m\/s), horses completed 2 min running at 120% maximum oxygen consumption (V\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2max<\/jats:sub>\n                    ) with the treadmill set at 3\u00b0 incline. Mean \u00b1 s.d. running speed was 14.2 \u00b1 0.2 m\/s. In the FR and NS + FR trials, horses carried weight equal to that lost as a result of frusemide administration. During exercise at 120%V\u0307O\n                    <jats:sub>2max<\/jats:sub>\n                    , oxygen consumption (V\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    ) and carbon dioxide production (V\n                    <jats:sc>co<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    ) were measured at 15 s intervals. Plasma lactate concentration was measured in samples collected before exercise, at the end of the sprint and after 5 min cooldown at the trot. Thirty minutes after the run, bronchoalveolar lavage (BAL) was performed and the red cell count in the fluid quantified. V\n                    <jats:sc>o<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    and V\n                    <jats:sc>co<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    were significantly lower in NS and NS + FR trials than in the C and FR trials at the end of the sprint exercise protocol. However, plasma lactate concentrations did not differamong treatments. Compared with the C trial (61.1 \u00b1 30.5 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    red blood cells\/ml BAL fluid), pulmonary haemorrhage was significantly (P&lt;0.05) decreased in both the NS (15.9 \u00b1 4.0 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    RBC\/ml) and FR (12.2 \u00b1 5.8 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    RBC\/ml) trials. EIPH in the NS + FR trial (7.9 \u00b1 1.0 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    RBC\/ml) was further diminished (P&lt;0.05) compared to the NS trial, but not different from the FR trial. We conclude that both the external nasal strip and frusemide attenuate pulmonary haemorrhage in Thoroughbred horses during high\u2010speed sprint exercise. The external nasal strip appears to lowerthe metabolic cost of supramaximal exertion in horses. Given the purported ergogenic effects of frusemide, the external nasal strip is a valuable alternative for the attenuation of EIPH.\n                  <\/jats:p>","DOI":"10.2746\/042516401776563490","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"577-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Effects of an external nasal strip and frusemide on pulmonary haemorrhage in Thoroughbreds following high\u2010intensity exercise"],"prefix":"10.1111","volume":"33","author":[{"given":"R. J.","family":"GEOR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"OMMUNDSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"FENTON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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