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Eight horses were injected i.m. with a single dose of 2.4 mg imidocarb dipropionate\/kg bwt and blood, faecal, urine and milk samples were collected.\n                  <\/jats:p>\n                  <jats:p>For imidocarb determination, a high\u2010performance liquid chromatographic method (HPLC) was used afterweak cation\u2010exchange solid phase, or liquid\u2010liquid, extraction procedures. Twelve hours after treatment, no detectable plasma concentrations were recorded in any of the treated animals. The distribution and elimination patterns of the drug suggested that it is quickly sequestrated in some storage tissues and remains in the body for a long time. Its prolonged presence in the body may confer a reservoir effect to imidocarb in some tissues, therefore making it undetectable in the plasma of animals but sufficient to produce its described therapeutic and prophylactic activities.<\/jats:p>","DOI":"10.2746\/042516402776180124","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"625-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration"],"prefix":"10.1111","volume":"34","author":[{"given":"C.","family":"BELLOLI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"CRESCENZO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"LAI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"CAROFIGLIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"MARANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"ORMAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1983.tb00464.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(95)80010-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.2460\/ajvr.1977.38.12.2001","article-title":"Absorption, distribution and excretion of imidocarb dipropionate in sheep","volume":"38","author":"Aliu Y.O.","year":"1977","journal-title":"Am. 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