{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:16:25Z","timestamp":1785338185638,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":2806,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Dorsal carpal osteochondral injury is a major cause of lameness in horses undergoing high intensity training. Intra\u2010articular corticosteroid treatment is used commonly to manage exercise\u2010associated articular pain, but its use remains highly controversial in the equine athlete. This project, therefore, aimed to compare the mechanical properties of intra\u2010articular MPA and diluent\u2010treated middle carpal subchondral and cancellous bone in horses undergoing a short\u2010term treadmill exercise programme. It was hypothesised that subchondral and cancellous bone mechanical properties are influenced by intra\u2010articular administration of methylprednisolone acetate (MPA). Eight 2\u2010year\u2010old female horses had MPAor diluent administered into contralateral middle carpal joints at 14 day intervals, for a total of 4 treatments per horse. Horses underwent a standard treadmill exercise protocol until euthanasia (Day 70). Standard sites were located on the dorsal aspect of third, radial and intermediate carpal bones. Osteochondral samples from each test site were divided into subchondral bone and cancellous bone portions. These were dried, resin\u2010embedded and gold\u2010coated. Microhardness measurements were obtained at each test site. No significant effect of intra\u2010articular treatment was detected. At each site, cancellous bone trabecular struts had an 18\u201319% higher microhardness value than the overlying subchondral bone. These findings indicate that intra\u2010articularadministration of MPA at this dose has no effect on subchondral or cancellous bone adaptation to short\u2010term exercise and, therefore, on the propensity of carpal bones to injury. Further investigation into the calcified cartilage layer, effect of different corticosteroid preparations and diffusion of medication are required.<\/jats:p>","DOI":"10.2746\/042516402776185994","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"306-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The effect of intra\u2010articular methylprednisolone acetate and exercise on equine carpal subchondral and cancellous bone microhardness"],"prefix":"10.1111","volume":"34","author":[{"given":"R. C.","family":"MURRAY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"ZNAOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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