{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:20:17Z","timestamp":1780428017736,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":2318,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : Liver disease is fairly common in horses and, although previous literature suggests that fatality rates are high, impressions gained from current clinical practice suggest that this is no longer the case.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : A case\u2010control study was undertaken in 2 hospitals to investigate whetherage, gender or breed type predisposed horses to developing hepatic disease, with the additional aim of determining whether these factors and disease category had any effect on outcome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : Eighty\u2010eight cases were identified by review of computerised archives at 2 hospitals. Three cases admitted immediately before and afterthe cases were used as controls. Multivariant models were developed to explore the relationship between age, breed type and gender and the development of liverdisease, and within the clinical cases, to identify whetherany of these factors orspecific forms of liver disease were associated with fatality rate.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : Ponies were more likely to develop hepatic disease than light riding horses, but neither age nor gender were significant risk factors. Overall, the fatality rate was fairly low; horses with unclassified hepatopathies had the lowest fatality rate and those with cholangiohepatitis, pyrrolizidine alkaloid toxicity and chronic active hepatitis had significantly higher fatality rates in comparison. However, age, breed type and gender had no detectable effect on outcome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions and potential relevance<\/jats:italic>\n                    : Such data could be of particular value to equine practitioners, as the cases were drawn from both primary and referral practice, and were all seen within the last 5 years.\n                  <\/jats:p>","DOI":"10.2746\/042516403775467207","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"549-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Equine hepatic disease: the effect of patient\u2010 and case\u2010specific variables on risk and prognosis"],"prefix":"10.1111","volume":"35","author":[{"given":"M. R. W.","family":"SMITH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. B.","family":"STEVENS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"DURHAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"MARR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2460\/javma.1995.207.03.325","article-title":"Case control study of risk factors for development of pleuropneumonia in horses","volume":"207","author":"Austin S.M.","year":"1995","journal-title":"J. Am. vet. med. Ass."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2460\/javma.1995.206.05.667","article-title":"Case control study of the association between various management factors and development of colic in horses. Texas Equine Colic Study Group","volume":"206","author":"Cohen N.D.","year":"1995","journal-title":"J. Am. vet. med. 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Ass. equine Practnrs."},{"key":"e_1_2_1_13_1","unstructured":"West H.J.(1994)The Evaluation of Hepatobiliary Disease in Horses and Cattle FRCVS Thesis London ."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1996.tb01607.x"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2746%2F042516403775467207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.2746\/042516403775467207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:38:31Z","timestamp":1762090711000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.2746\/042516403775467207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.2746\/042516403775467207"],"URL":"https:\/\/doi.org\/10.2746\/042516403775467207","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]},"assertion":[{"value":"2010-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}