{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:02:32Z","timestamp":1789657352636,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":2410,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : Corticosteroids are currently the most effective drugs for the control of \u2018heaves\u2019 in horses. However, there is limited information concerning the comparative efficacy and tolerability of the various corticosteroids when used for treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : To compare the therapeutic and side effects of isoflupredone acetate to those of dexamethasone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : A parallel design to compare the effects of 2 corticosteroids by evaluating lung function, serum cortisol and electrolyte concentrations, response to ACTH stimulation and haematology sequentially during a 14 day control period (no treatment), followed by 14 day treatment with either isoflupredone acetate (0.03 mg\/kg i.m. s.i.d., n = 6) or dexamethasone (0.04 mg\/kg i.v. s.i.d., n = 6) and 7 days of wash\u2010out.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : Both drugs were well tolerated clinically and resulted in a significant improvement in lung function that started on Day 3 and lasted for the treatment and wash\u2010out periods. Blood cortisol levels were significantly decreased during the treatment period in both groups of horses, but a normal response to ACTH stimulation was preserved. Serum electrolytes concentration of horses receiving dexamethasone was not affected by the treatment, but horses treated with isoflupredone demonstrated a significant decrease in serum potassium level. Both treatments induced stress changes in haematology.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions and potential relevance<\/jats:italic>\n                    : Isoflupredone is as effective as dexamethasone in the treatment of \u2018heaves\u2019\u2010affected horses but associated with hypokalaemia. Even if clinical signs of hypokalaemia were not observed, this is a side effect that deserves further investigation.\n                  <\/jats:p>","DOI":"10.2746\/042516403776014208","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"419-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction (\u2018heaves\u2019)"],"prefix":"10.1111","volume":"35","author":[{"given":"V.","family":"PICANDET","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"L\u00c9GUILLETTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. \u2010P.","family":"LAVOIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.2460\/javma.1992.200.11.1682","article-title":"Steroid hepatopathy in a horse with glucocorticoid\u2010induced hyperadrenocorticism","volume":"200","author":"Cohen N.D.","year":"1992","journal-title":"J. Am. vet. med. Ass."},{"key":"e_1_2_1_3_1","first-page":"1237","volume-title":"Large Animal Internal Medicine","author":"Dybdal N.O.","year":"2001"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2460\/ajvr.1979.40.05.727","article-title":"Adrenal gland function in the horse: effect of dexamethasone on hydrocortisone secretion and blood cellularity and plasma electrolyte concentrations","volume":"40","author":"Eiler H.","year":"1979","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-6-842"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30312-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.2460\/ajvr.1993.54.08.1310","article-title":"Effects of triamcinolone acetonide on pulmonary function and bronchoalveolar lavage cytologic features in horses with chronic obstructive pulmonary disease","volume":"54","author":"Lapointe J.M.","year":"1993","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_8_1","first-page":"431","volume-title":"Current Therapy in Equine Medicine","author":"Lavoie J.P.","year":"1997"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2002.63.579"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2460\/ajvr.1985.46.11.2285","article-title":"Effects of multiple intramuscular injections and doses of dexamethasone on plasma cortisol concentrations and adrenal responses to ACTH in horses","volume":"46","author":"MacHarg M.A.","year":"1985","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.138.9.205"},{"key":"e_1_2_1_12_1","volume-title":"Veterinary Pharmacology and Therapeutics","author":"McDonald L.E.","year":"1988"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1973.tb03191.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2460\/javma.1972.161.01.53","article-title":"Effect of ACTH and selected glucocorticoids on circulating blood cells in horses","volume":"161","author":"Osbaldiston G.W.","year":"1972","journal-title":"J. Am. vet. med. Ass."},{"key":"e_1_2_1_15_1","first-page":"235","article-title":"Hypokalaemia, muscle weakness and recumbency in dairy cattle","volume":"1","author":"Peek S.F.","year":"2000","journal-title":"Vet. Therapeutics"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776767412"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(96)80101-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516402776181105"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2460\/ajvr.1998.59.08.1044","article-title":"Alteration in adrenocortical function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively","volume":"59","author":"Rush B.R.","year":"1998","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1998.59.08.1039"},{"key":"e_1_2_1_21_1","unstructured":"Sattler N. Fecteau G.andPare J.(2002)Experimental reporoduction of the bovine hypokalemia syndrome. In:Proceedings of the 20th Annual American Colllege of Veterinary Internal Medicine Forum Dallas. p771."},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2460\/javma.1997.210.02.240","article-title":"Hypokalemia syndrome in dairy cows: 10 cases (1992\u20131996)","volume":"210","author":"Sielman E.S.","year":"1997","journal-title":"J. Am. vet. med. Ass."},{"key":"e_1_2_1_23_1","first-page":"469","article-title":"Effects of dexamethasone and triamcinolone that may predispose to laminits in horses","volume":"27","author":"Slone D.E.","year":"1981","journal-title":"Proc. Am. Ass. equine Practnrs."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2460\/ajvr.1983.44.02.280","article-title":"Sodium retention and cortisol (hydrocortisone) suppression caused by dexamethasone and triamcinolone in equids","volume":"44","author":"Slone D.E.","year":"1983","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_25_1","unstructured":"Straub R.andGerber H.(1975)Effects of prolonged use of corticosteroids. In:Proceedings of the 1st International Symposium in Haematology.pp 536\u2013553."},{"key":"e_1_2_1_26_1","first-page":"129","article-title":"Suppression of the cell mediated immune system of the horse by systemic corticosteroid administration","volume":"2","author":"Tarr M.J.","year":"1978","journal-title":"J. Equine Med. Surg."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.2460\/ajvr.1984.45.09.1750","article-title":"Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland","volume":"45","author":"Toutain P.L.","year":"1984","journal-title":"Am. J. vet. Res."},{"key":"e_1_2_1_28_1","first-page":"80","article-title":"Hypokalaemic myopathy in pseudohyperaldosteronism induced by fluoroprednisolone\u2010containing nasal spray","volume":"6","author":"Vita G.","year":"1987","journal-title":"Clin. Neuropath."}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2746%2F042516403776014208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.2746\/042516403776014208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:38:20Z","timestamp":1762072700000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.2746\/042516403776014208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.2746\/042516403776014208"],"URL":"https:\/\/doi.org\/10.2746\/042516403776014208","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]},"assertion":[{"value":"2010-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}