{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:24:03Z","timestamp":1762100643629,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":1891,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : It has been shown that the selective 5\u2010HT4 receptor agonist tegaserod induces an increase in frequency and amplitude of contractions in isolated muscle preparations of equine ileum and pelvic flexure.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : To investigate the effects of tegaserod on gut motility and transit of spheres in normal horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : Six mature Freiberger horses were kept under standardised conditions. Effects of tegaserod (0.02 mg\/kg bwt i.v. b.i.d. for 2 days) or vehicle on intestinal transit of barium\u2010filled spheres, defaecation and gut sounds were studied in a cross\u2010over design. Spheres were given via stomach tube prior to the first dosing of tegaserod or vehicle. Faeces were collected every 3 h and spheres eliminated were identified radiologically in the faeces.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : Tegaserod significantly accelerated the gastrointestinal (GI) transit time of spheres and increased the frequency of defaecation and scores of gut sounds compared to vehicle. The compound was well tolerated; no effects on behaviour, body temperature, heart rate, respiratory rate and clinical laboratory data were observed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : Tegaserod efficaciously stimulated motility and accelerate GI transit in healthy horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Potential relevance<\/jats:italic>\n                    : Tegaserod may offer therapeutic potential in horses suffering from impaction or paralytic ileus.\n                  <\/jats:p>","DOI":"10.2746\/0425164044864543","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"622-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Tegaserod (HTF 919) stimulates gut motility in normal horses"],"prefix":"10.1111","volume":"36","author":[{"given":"B. 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