{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:02:37Z","timestamp":1762081357917,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":1891,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2004,11]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:italic>\n : It has been suggested that rapid administration of isotonic saline solution relieves airway obstruction in heaves\u2010affected horses, but the efficacy and tolerability of this treatment is poorly documented.\n <\/jats:p>\n \n Objectives<\/jats:italic>\n : To determine the respiratory and metabolic effects of a rapid administration of isotonic saline solution in control horses and those with heaves.\n <\/jats:p>\n \n Methods<\/jats:italic>\n : Thirty litres isotonic saline solution were administered i.v. to 5 control (\n Group C<\/jats:italic>\n ) and 9 heaves\u2010affected horses (\n Group H<\/jats:italic>\n ). Pulmonary function testing and arterial blood gas analysis were performed prior to saline infusion, at 90 and 180 mins after starting the infusion, and 1, 3, 6 and 10 days later. PCV, plasma total solids, plasma electrolytes (Na+, Cl\u2010 and K+) and venous blood gas analysis were performed prior, during and after saline infusion.\n <\/jats:p>\n \n Results<\/jats:italic>\n : Rapid saline administration was shown to have no beneficial effects on lung function during infusion in\n Group H.<\/jats:italic>\n On the contrary, they had significantly increased pulmonary resistance (R\n L<\/jats:sub>\n ) at 180 mins following the initiation of saline administration compared to baseline. In\n Group C<\/jats:italic>\n , saline administration resulted in a significant increase in R\n L<\/jats:sub>\n at 180 mins and a significant decrease in PaO\n 2<\/jats:sub>\n at 90 mins. These results suggest a transient decrement in lung function caused by rapid saline administration.\n Group H<\/jats:italic>\n had a metabolic alkalosis with hypochloraemia at baseline compared to control horses. This resolved following i.v. saline administration and returned to baseline within 6 h after treatment had been discontinued.\n <\/jats:p>\n \n Conclusion<\/jats:italic>\n : The administration of saline to\n Group H<\/jats:italic>\n did not improve airway function significantly, but resulted in mild and transient side effects.\n <\/jats:p>\n \n Potential relevance<\/jats:italic>\n : Rapid administration of isotonic saline alone is not an effective therapy for heaves in horses.\n <\/jats:p>","DOI":"10.2746\/0425164044864570","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"628-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Respiratory and metabolic effects of massive administration of isotonic saline solution in heaves\u2010affected and control horses"],"prefix":"10.1111","volume":"36","author":[{"given":"D.","family":"JEAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"VRINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010P.","family":"LAVOIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2460\/ajvr.1990.51.07.999","article-title":"Effect of hypertonic vs isotonic saline solution on responses to sublethal Escherichia coli endotoxemia in horses","volume":"51","author":"Bertone J.J.","year":"1990","journal-title":"Am. 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