{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:04:26Z","timestamp":1791086666755,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":1891,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : Intrauterine growth retardation (IUGR) impairs post natal adaptive responses and is associated with increased adrenocortical activity in many species.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : To determine whether a restricted or enhanced intrauterine environment affects neonatal adaptation and adrenocortical function in horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : Embryos from large (577 kg) Thoroughbred (TB) mares were transferred to smaller (343 kg) pony (P) mares and\n                    <jats:italic>vice versa<\/jats:italic>\n                    , to create a restricted (TB\u2010in\u2010P, n = 11) or enhanced (P\u2010in\u2010TB, n = 8) intrauterine environment. Control groups (TB\u2010in\u2010TB, n = 8; P\u2010in\u2010P, n = 7) were also included.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : Thirty foals were born live at full term (range 314\u2010348 days) and 4 (3 TB\u2010in\u2010P, 1 P\u2010in\u2010TB) were stillborn between 275 and 335 days. TB\u2010in\u2010P foals were significantly (P&lt;0.05) lighter than TB\u2010in\u2010TB, but heavier than P\u2010in\u2010P foals. TB\u2010in\u2010P foals took longer to first stand and suck and some had fetlock hyperextension and low (&lt;4 g\/l) plasma immunoglobulin G concentrations. Other foal groups showed normal behavioural responses. Haematological parameters were normal in all 4 groups of foals. Plasma ACTH levels were high at birth and plasma cortisol concentrations increased after delivery and returned to baseline within 6 h\n                    <jats:italic>post partum<\/jats:italic>\n                    in all but the TB\u2010in\u2010P foals, which had elevated levels until 48 h\n                    <jats:italic>post partum.<\/jats:italic>\n                    Plasma cortisol concentrations increased in all groups following exogenous ACTH administered on Days 1 and 5\n                    <jats:italic>post partum.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : The TB\u2010in\u2010P foals showed IUGR and impaired post natal adaptive responses with basal hypercortisolaemia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Potential relevance<\/jats:italic>\n                    : Foals born following IUGR may require clinical assistance in the early post natal period, but appear mature with respect to adrenocortical function.\n                  <\/jats:p>","DOI":"10.2746\/0425164044864598","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"616-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Effects of manipulating intrauterine growth on post natal adrenocortical development and other parameters of maturity in neonatal foals"],"prefix":"10.1111","volume":"36","author":[{"given":"J. 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