{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:05:46Z","timestamp":1782248746690,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":1771,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : Sex chromosome aberrations are often associated with clinical signs that affect equine health and reproduction. However, abnormal manifestation with sex chromosome aberration usually appears at maturity and potential disorders may be suspected infrequently. A reliable survey at an early stage is therefore required.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : To detect and characterise sex chromosome aberrations in newborn foals by the parentage test and analysis using X\u2010 and Y\u2010linked markers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : We conducted a genetic diagnosis combined with a parentage test by microsatellite DNA and analysis of X\u2010 and Y\u2010linked genetic markers in newborn light\u2010breed foals (n = 17, 471). The minimum incidence of sex chromosome aberration in horses was estimated in the context of available population data.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : Eighteen cases with aberrations involving 63,XO, 65,XXY and 65,XXX were found. The XO, XXY (pure 65,XXY and\/or mosaics\/chimaeras) and XXX were found in 0.15, 0.02 and 0.01% of the population, respectively, based solely on detection of abnormal segregation of a single X chromosome marker,\n                    <jats:italic>LEX003.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions and potential relevance<\/jats:italic>\n                    : Detection at an early age and understanding of the prevalence of sex chromosome aberrations should assist in the diagnosis and managment of horses kept for breeding. Further, the parental origin of the X chromosome of each disorder could be proved by the results of genetic analysis, thereby contributing to cytogenetic characterisation.\n                  <\/jats:p>","DOI":"10.2746\/0425164054223787","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"143-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetic diagnosis of sex chromosome aberrations in horses based on parentage test by microsatellite DNA and analysis of X\u2010 and Y\u2010linked markers"],"prefix":"10.1111","volume":"37","author":[{"given":"H.","family":"KAKOI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"HIROTA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"GAWAHARA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"KUROSAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"KUWAJIMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1997.00123.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/9780851994291.0171"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.917503"},{"key":"e_1_2_1_5_1","first-page":"126","article-title":"Equine dinucleotide repeat polymorphisms at loci LEX002, \u2212003, \u2212004, \u2212005, \u2212007, \u2212008, \u2212009, \u2212010, \u2212011, \u2212013 and \u2212014","volume":"27","author":"Coogle L.","year":"1996","journal-title":"Anim. Genet."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1996.tb00500.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.1997.00188.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.23.1.120"},{"key":"e_1_2_1_9_1","first-page":"J6","article-title":"Sex determination of equine somatic and germ cells by PCR amplification based on the sequence polymorphism of X\u2010 and Y\u2010chromosomal amelogenin genes","volume":"70","author":"Fukushima Y.","year":"1999","journal-title":"Anim. Sci. J."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.8.547"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.62.1109"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2052.2001.0723a.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2052.2001.0730h.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.1997.6160471.x"},{"key":"e_1_2_1_15_1","first-page":"453","article-title":"DNA typing with 17 microsatellites for parentage verification of racehorses in Japan","volume":"72","author":"Kakoi H.","year":"2001","journal-title":"Anim. Sci. J."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2000.579-1.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776254844"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009275102977"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2052.1999.00377.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00204942"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg028"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.63.1191"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esh020"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2746%2F0425164054223787","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.2746\/0425164054223787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:06:51Z","timestamp":1762085211000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.2746\/0425164054223787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.2746\/0425164054223787"],"URL":"https:\/\/doi.org\/10.2746\/0425164054223787","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"2010-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}