{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:57:18Z","timestamp":1787025438175,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":1526,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : There is conflicting evidence over the role seminal plasma plays in sperm transport and inflammation within the uterus of mares. In\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies, seminal plasma has been shown to reduce polymorphonuclear neutrophil (PMN) function, but the opposite effect on uterine inflammation has been reported\n                    <jats:italic>in vivo.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    : To study the effect of seminal plasma on uterine contractility, inflammation and pregnancy rates by inseminating mares with low doses of sperm free from seminal plasma (\n                    <jats:italic>Group 1<\/jats:italic>\n                    ) and containing seminal plasma (\n                    <jats:italic>Group 2<\/jats:italic>\n                    ).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : Synchronised mares were inseminated with 50 times 10\n                    <jats:sup>6<\/jats:sup>\n                    sperm in either skim milk extender or seminal plasma. Uterine lavage was performed 6 h after insemination to assess the inflammatory response. The contraction frequency of the uterus was measured over a 4 min period 10 mins and 6 h after insemination, using B\u2010mode ultrasonography. Pregnancy rates were assessed 16 days after insemination.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : Uterine contractions were less frequent in\n                    <jats:italic>Group 1<\/jats:italic>\n                    mares inseminated with seminal plasma and significantly more PMNs were found in the lavage fluid of those mares. Pregnancy rates were identical in both groups (62%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    : This study provides evidence that seminal plasma decreases uterine contractility and increases the inflammatory response of the uterus to semen. No effect of seminal plasma on pregnancy rates was demonstrated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Potential relevance<\/jats:italic>\n                    : Mares that develop persistent mating\u2010induced endometritis may have inherently poor uterine contractility and impaired uterine clearance. The presence of seminal plasma during breeding may not be desirable in these mares. The role of seminal plasma in problem mares warrants additional study.\n                  <\/jats:p>","DOI":"10.2746\/042516405775314844","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T19:03:27Z","timestamp":1176404607000},"page":"515-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of seminal plasma on uterine inflammation, contractility and pregnancy rates in mares"],"prefix":"10.1111","volume":"37","author":[{"given":"B. J.","family":"PORTUS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"REILAS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"KATILA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"445","article-title":"Effect of uterine inflammation and ultrasonically detected uterine pathology on fertility in the mare","volume":"35","author":"Adams G.P.","year":"1987","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)49990-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1993.tb02940.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.122.20.489"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.007013"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.013425"},{"key":"e_1_2_1_8_1","first-page":"59","article-title":"An investigation of sperm migration into the oviducts of the mare","volume":"32","author":"Bader H.","year":"1982","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_9_1","first-page":"131","article-title":"Inflammatory response in the pig uterus induced by seminal plasma","volume":"40","author":"Bischof R.J.","year":"1994","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(03)00084-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00768-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.155.4.103"},{"key":"e_1_2_1_13_1","first-page":"297","article-title":"Postcopulatory myometrial activity in the rat as seen by video\u2010laparascopy","volume":"39","author":"Crane L.H.","year":"1991","journal-title":"Reprod. Fert. Dev."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/5.3.220"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0320117"},{"key":"e_1_2_1_16_1","first-page":"327","article-title":"Factors affecting uterine clearance of inoculated materials in mares","volume":"35","author":"Evans M.J.","year":"1987","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00831-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(98)00158-7"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(98)00202-7"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(96)00216-6"},{"key":"e_1_2_1_21_1","first-page":"73","article-title":"Seminal plasma (SPL): a potent mediator of inflammation in the uterus following mating in the pig","volume":"50","author":"Hadjisavas M.","year":"1994","journal-title":"Biol. Reprod."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(87)90073-8"},{"key":"e_1_2_1_23_1","first-page":"103","volume-title":"The Physiology of Reproduction","author":"Harper M.J.K.","year":"1988"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0737-0806(81)80011-1"},{"key":"e_1_2_1_25_1","first-page":"649","article-title":"Pregnancy rates utilizing fresh, cooled and frozen\/thawed stallion semen","volume":"38","author":"Jasko D.J.","year":"1992","journal-title":"Proc. Am. Ass. equine Practnrs."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(01)00162-2"},{"key":"e_1_2_1_27_1","first-page":"571","article-title":"Transport of sperm in the reproductive tracts of mares","volume":"56","author":"Katila T.","year":"2000","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(94)90173-G"},{"key":"e_1_2_1_29_1","first-page":"351","article-title":"Simultaneous recording of pituitary oxytocin secretion and myometrial activity in oestrous mares exposed to various breeding stimuli","volume":"56","author":"Madill S.","year":"2000","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.04.016"},{"key":"e_1_2_1_31_1","first-page":"181","article-title":"Prostaglandin release patterns in the mare: physiological. pathophysiological and therapeutic responses","volume":"27","author":"Neely D.P.","year":"1979","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00735-5"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00042-6"},{"key":"e_1_2_1_34_1","first-page":"540","article-title":"Influence of semen, extender and seminal plasma on the defense mechanism of the mare's uterus","volume":"13","author":"Parlevliet J.M.","year":"1997","journal-title":"Pferdeheilkunde"},{"key":"e_1_2_1_35_1","first-page":"95","article-title":"The effect of semen extenders and sperm number on mare fertility","volume":"23","author":"Pickett B.W.","year":"1975","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_36_1","first-page":"682","article-title":"Effects of spermatozoa, seminal plasma and extender on post\u2010breeding endometritis in mares","volume":"17","author":"Quetin M.","year":"2001","journal-title":"Pferdeheilkunde"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(01)00154-3"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/smim.2000.0320"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(03)00052-4"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1070265"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.2527\/1999.7782201x"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2003.12.011"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0870519"},{"key":"e_1_2_1_44_1","first-page":"130","volume-title":"Proceedings of the Annual Meeting for Theriogenology","author":"Troedsson M.H.T.","year":"1995"},{"key":"e_1_2_1_45_1","first-page":"807","article-title":"Sperm transport and survival in the mare: a review","volume":"50","author":"Troedsson M.H.T.","year":"1998","journal-title":"Theriogenol."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00862-2"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0990307"},{"key":"e_1_2_1_48_1","first-page":"341","article-title":"The role of seminal plasma in post\u2010breeding uterine inflammation","volume":"56","author":"Troedsson M.H.T.","year":"2000","journal-title":"J. Reprod. Fert."},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(01)00164-6"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(99)00032-1"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2746%2F042516405775314844","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.2746\/042516405775314844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:41:02Z","timestamp":1762072862000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.2746\/042516405775314844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.2746\/042516405775314844"],"URL":"https:\/\/doi.org\/10.2746\/042516405775314844","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"2010-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}