{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:44:33Z","timestamp":1775742273552,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":1161,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2006,11]]},"abstract":"Summary<\/jats:title>\n \n Reasons for performing study<\/jats:italic>\n : Many racing jurisdictions monitor pre\u2010race serum concentration of total carbon dioxide (TCO\n 2<\/jats:sub>\n ) among racing horses. To our knowledge, factors influencing concentration of TCO\n 2<\/jats:sub>\n among horses participating in racing have not been systematically evaluated and reported.\n <\/jats:p>\n \n Objectives<\/jats:italic>\n : To determine if characteristics of horses and racing conditions routinely recorded were significantly associated with pre\u2010race concentration of TCO\n 2<\/jats:sub>\n , while accounting for and estimating effects of trainer and horse.\n <\/jats:p>\n \n Methods<\/jats:italic>\n : Pre\u2010race serum TCO\n 2<\/jats:sub>\n concentrations from 5028 starts made by 2349 horses trained by 287 trainers at 2 racetracks in California during 2005 were examined. Data regarding characteristics of starters and race conditions obtained from a commercial database were recorded for each start. Data were analysed using mixed\u2010effects, with TCO\n 2<\/jats:sub>\n concentration as the dependent variable, and trainer and horse nested within trainer as random effects.\n <\/jats:p>\n \n Results<\/jats:italic>\n : Sex, class and distance of race, frusemide administration and cloudy weather conditions were significantly (P < 0.001) associated with pre\u2010race TCO\n 2<\/jats:sub>\n concentration. Horses that finished in the top 3 positions had values that were slightly (0.2 mmol\/l) but significantly (P < 0.001) greater than horses not finishing in the top 3. There were significant effects of trainer on pre\u2010race TCO\n 2<\/jats:sub>\n concentration.\n <\/jats:p>\n \n Conclusions<\/jats:italic>\n : A variety of factors may influence pre\u2010race TCO2 concentration in horses. Horses with better performance tend to have higher pre\u2010race TCO\n 2<\/jats:sub>\n concentrations.\n <\/jats:p>\n \n Potential relevance<\/jats:italic>\n : TCO\n 2<\/jats:sub>\n concentration is associated with improved performance although the magnitude of effect was quite small. Regulatory programmes based on monitoring should consider the influence of other factors on TCO\n 2<\/jats:sub>\n concentration.\n <\/jats:p>","DOI":"10.2746\/042516406x156479","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T11:37:06Z","timestamp":1173094626000},"page":"543-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Factors influencing pre\u2010race serum concentration of total carbon dioxide in Thoroughbred horses racing in California"],"prefix":"10.1111","volume":"38","author":[{"given":"N. D.","family":"COHEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"STANLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M.","family":"ARTHUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"WANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.2042-3306.2002.tb05476.x","article-title":"Effect of NaCl and NaHCO3 on serum ionized calcium and blood gas status during sprinting","volume":"34","author":"Beard L.A.","year":"2002","journal-title":"Equine vet. 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