{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:40:07Z","timestamp":1785577207203,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"vor","delay-in-days":430,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Reasons for performing study<\/jats:italic>\n                    : Only few drugs with limited efficacy are available for topical treatment of equine glaucoma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    : To evaluate the effect of topical administration of 1% brinzolamide on intraocular pressure (IOP) in clinically normal horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    : Healthy mature horses (n = 20) with normal ocular findings, were studied. The IOP was measured 5 times daily (07.00, 11.00, 15.00, 19.00 and 23.00 h) over 10 days. On Days 1 and 2, baseline values were established. On Days 3\u20135 one eye of each horse was treated with one drop of 1% brinzolamide every 24 h immediately following the 07.00 h measurement. On Days 6\u20138 the same eye was treated with 1% brinzolamide every 12 h (07.00 and 19.00 h). Measurements on Days 9 and 10 documented the return of IOP to baseline values. Statistical analysis of the data was performed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    : In the treated eye a significant decrease in IOP compared to baseline values was noted during both the 24 and 12 h dosing periods (P&lt;0.001). During the once\u2010daily treatment protocol an IOP reduction of 3.1 \u00b11.3 mmHg (14%) from baseline was recorded. During the twice\u2010daily protocol a total IOP reduction of 5.0 \u00b1 1.5 mmHg (21%) was achieved.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Intraocular pressure was significantly decreased by 1% brinzolamide in a once\u2010daily and a twice\u2010daily treatment protocol in normotensive eyes. These findings suggest that brinzolamide might also be effective in horses with an elevated IOP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Potential relevance<\/jats:italic>\n                    : This drug may be useful for treatment of equine glaucoma.\n                  <\/jats:p>","DOI":"10.2746\/042516408x297426","type":"journal-article","created":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T18:27:01Z","timestamp":1225564021000},"page":"662-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of topical administration of 1% brinzolamide on intraocular pressure in clinically normal horses"],"prefix":"10.1111","volume":"40","author":[{"given":"S. E.","family":"GERMANN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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