{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:23:22Z","timestamp":1792790602576,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T00:00:00Z","timestamp":1265673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Reasons for performing study:<\/jats:bold>\n                    The horse owner assessed respiratory signs index (HOARSI\u20101\u20134, healthy, mildly, moderately and severely affected, respectively) is based on owner\u2010reported clinical history and has been used for the investigation of recurrent airway obstruction (RAO) genetics utilising large sample sizes. Reliable phenotype identification is of paramount importance in genetic studies. Owner reports of respiratory signs have shown good repeatability, but the agreement of HOARSI with an in\u2010depth examination of the lower respiratory tract has not been investigated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    To determine the correlation of HOARSI\n                    <jats:italic>grades 3\/4<\/jats:italic>\n                    with the characteristics of RAO and of HOARSI\u20102 with the characteristics of inflammatory airway disease. Further, to test whether there are phenotypic differences in the manifestation of lung disease between families.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Seventy\u2010one direct offspring of 2 RAO\u2010affected Warmblood stallions (33 from the first family, 38 from the second) were graded as HOARSI\u20101\u20134 and underwent a clinical examination of the respiratory system, arterial blood gas analysis, endoscopic mucus scoring, cytology of tracheobronchial secretion (TBS) and bronchoalveolar lavage fluid (BALF), and clinical assessment of airway reactivity to methacholine chloride.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    HOARSI\u20103\/4 animals in clinical exacerbation showed signs consistent with RAO: coughing, nasal discharge, abnormal lung sounds and breathing pattern as well as increased numbers of neutrophils in TBS and BALF, excessive mucus accumulation and airway hyper\u2010responsiveness to methacholine. HOARSI\u20103\/4 horses in remission only had increased amounts of tracheal mucus and TBS neutrophil percentages. Clinical phenotypes were not significantly different between the 2 families.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and clinical relevance:<\/jats:bold>\n                    HOARSI reliably identifies RAO\u2010affected horses in our population.\n                  <\/jats:p>","DOI":"10.2746\/042516409x479586","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T14:30:49Z","timestamp":1280500249000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Relationship of horse owner assessed respiratory signs index to characteristics of recurrent airway obstruction in two Warmblood families"],"prefix":"10.1111","volume":"42","author":[{"given":"E.","family":"LAUMEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. G.","family":"DOHERR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"GERBER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"357","article-title":"Airway responses to aerosolized metacholine and citric acid in ponies with recurrent airway obstruction (heaves)","volume":"133","author":"Armstrong P.J.","year":"1986","journal-title":"Am. Rev. Resp. Dis."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200401000-00008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1995.tb04423.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1989.tb02084.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.2.598"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0292.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516403775600424"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164044864525"},{"key":"e_1_2_7_10_1","first-page":"92","article-title":"Airway mucus in recurrent airway obstruction \u2013 short\u2010term response to environmental challenge","volume":"18","author":"Gerber V.","year":"2004","journal-title":"J. vet. intern. Med."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.338"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2006.01.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516407X171110"},{"key":"e_1_2_7_14_1","first-page":"19","article-title":"Asthma phenotypes","volume":"13","author":"Kiley J.","year":"2007","journal-title":"Curr. Opin. Pulm. Med."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2003.tb12540.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb02941.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776767412"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1935(96)80101-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.550"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.1414"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2746%2F042516409X479586","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.2746\/042516409X479586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:04:22Z","timestamp":1762077862000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.2746\/042516409X479586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,9]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.2746\/042516409X479586"],"URL":"https:\/\/doi.org\/10.2746\/042516409x479586","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,9]]},"assertion":[{"value":"2010-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}