{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:31:13Z","timestamp":1790465473192,"version":"4.1.0"},"reference-count":0,"publisher":"European Centre for Disease Control and Prevention (ECDC)","issue":"46","license":[{"start":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T00:00:00Z","timestamp":1290038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,18]]},"abstract":"<jats:p>We report the successful control of an outbreak caused by imipenem-resistant VIM-1-producing Klebsiella pneumoniae (IR-Kp) in France. This outbreak occurred in a care centre for abdominal surgery that includes a 15-bed liver intensive care unit and performs more than 130 liver transplantations per year. The index case was a patient with acute liver failure transferred from a hospital in Greece for urgent liver transplantation who was carrying IR-Kp at admission as revealed by routine culture of a rectal swab. Infection control measures were undertaken and included contact isolation and promotion of hand hygiene with alcohol-based hand rub solution. Nevertheless, secondary IR-Kp cases were identified during the six following months from 3 December 2003 to 2 June 2004. From 2 June to 21 October, extended infection control measures were set up, such as cohorting IR-Kp carriers, contact patients and new patients in distinct sections with dedicated staff, limiting ward admission, and strict control of patient transfer. They led to a rapid control of the outbreak. The  global attack rate of the IR-Kp outbreak was 2.5%, 13% in liver transplant patients and 0.4% in the other patients in the care centre (p&lt;0.005). Systematic screening for IR-Kp of all patients admitted to the care centre is still maintained to date and no secondary IR-Kp case has been detected since 2 June 2004. \n<\/jats:p>","DOI":"10.2807\/ese.15.46.19713-en","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T11:55:18Z","timestamp":1511870118000},"update-policy":"https:\/\/doi.org\/10.2807\/1560-7917.es.crp2020","source":"Crossref","is-referenced-by-count":31,"title":["Extended measures for controlling an outbreak of VIM-1 producing imipenem-resistant Klebsiella pneumoniae in a liver transplant centre in France, 2003\u20132004"],"prefix":"10.2807","volume":"15","author":[{"given":"N","family":"Kassis-Chikhani","sequence":"first","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Paul Brousse, Microbiology Laboratory, Villejuif, France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Paul Brousse, Infection Control Unit, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Saliba","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Paul Brousse, Centre H\u00e9pato-Biliaire, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Carbonne","sequence":"additional","affiliation":[{"name":"Centre de Coordination de la Lutte contre les Infections Nosocomiales (CCLIN, Coordinating centre in the fight against nosocomial infections) Paris-Nord, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Neuville","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, Central Infection Control Team, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Decre","sequence":"additional","affiliation":[{"name":"ER8 Antibiotiques et Flore digestive, Universit\u00e9 Paris 6, Paris, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Samuel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, UMR 785, Villejuif, France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Paul Brousse, Centre H\u00e9pato-Biliaire, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Castaing","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, UMR 785, Villejuif, France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Paul Brousse, Centre H\u00e9pato-Biliaire, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dussaix","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Sud, UMR 785, Villejuif, France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Paul Brousse, Microbiology Laboratory, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Jarlier","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, hospital Piti\u00e9-Salp\u00e9tri\u00e8re, Paris, France"},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, Central Infection Control Team, Paris, France"},{"name":"Universit\u00e9 Pierre et Marie Curie,  Paris 6, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7995","container-title":["Eurosurveillance"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T13:47:26Z","timestamp":1663249646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurosurveillance.org\/content\/10.2807\/ese.15.46.19713-en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,18]]},"references-count":0,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2010,11,18]]}},"URL":"https:\/\/doi.org\/10.2807\/ese.15.46.19713-en","relation":{},"ISSN":["1560-7917"],"issn-type":[{"value":"1560-7917","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11,18]]}}}