{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:28:38Z","timestamp":1789450118957,"version":"build-2803163510"},"reference-count":0,"publisher":"European Centre for Disease Control and Prevention (ECDC)","issue":"7","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:p>The new meningococcal C conjugate vaccine became available in Spain and was included in the infant vaccination schedule in 2000. A catch-up campaign was carried out in children under six years of age. As a consequence, the incidence of meningococcal disease caused by serogroup C has fallen sharply during the last three epidemiological years in Spain. The risk of contracting serogroup C disease in 2002\/2003 fell by 58% when compared with the season before the conjugate vaccine was introduced. There was also an important decrease in mortality. Three deaths due to serogroup C occurred in the age groups targeted for vaccination in 2002\/2003, compared with 30 deaths in the same age groups in the season before the launch of the vaccine campaign. In the catch-up campaign the vaccine coverage reached values above 92%. For the 2001, 2002 and 2003 routine childhood immunisation programme coverage values ranged from 90% to 95%. During the past three years a total of 111 cases of serogroup C disease have been reported in patients in the vaccine target group. Most of the vaccination failures occurred during the epidemiological year 2002\/2003. Eight (53%) vaccine failures occurred in children who had been routinely immunised in infancy, and could be related to a lost of protection with time since vaccination. The isolation of several B:2a:P1.5 strains (ST-11 lineage) is noteworthy. These may have their origin in C:2a:P1.5 strains which, after undergoing genetic recombination at the capsular operon level, express serogroup B. These strains could have relevant epidemic potential.<\/jats:p>","DOI":"10.2807\/esm.09.07.00474-en","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T11:55:16Z","timestamp":1507118116000},"page":"5-6","update-policy":"https:\/\/doi.org\/10.2807\/1560-7917.es.crp2020","source":"Crossref","is-referenced-by-count":37,"title":["Impact of the meningococcal C conjugate vaccine in Spain: an epidemiological and microbiological decision"],"prefix":"10.2807","volume":"9","author":[{"given":"R","family":"Cano","sequence":"first","affiliation":[{"name":"Surveillance Unit, Centro Nacional de Epidemiolog\u00eda, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Larrauri","sequence":"additional","affiliation":[{"name":"Surveillance Unit, Centro Nacional de Epidemiolog\u00eda, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mateo","sequence":"additional","affiliation":[{"name":"Surveillance Unit, Centro Nacional de Epidemiolog\u00eda, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Alcal\u00e1","sequence":"additional","affiliation":[{"name":"Reference Laboratory for Meningococci, National Centre for Microbiology, National Institute of Health Carlos III, Majadahonda (Madrid). Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Reference Laboratory for Meningococci, National Centre for Microbiology, National Institute of Health Carlos III, Majadahonda (Madrid). Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Reference Laboratory for Meningococci, National Centre for Microbiology, National Institute of Health Carlos III, Majadahonda (Madrid). Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7995","container-title":["Eurosurveillance"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T10:39:24Z","timestamp":1663238364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurosurveillance.org\/content\/10.2807\/esm.09.07.00474-en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.2807\/esm.09.07.00474-en","relation":{},"ISSN":["1560-7917"],"issn-type":[{"value":"1560-7917","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7,1]]}}}