{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:22:11Z","timestamp":1767921731089,"version":"3.49.0"},"reference-count":11,"publisher":"European Centre for Disease Control and Prevention (ECDC)","issue":"37","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:p>We measured vaccine effectiveness (VE) against COVID-19-related severe outcomes in elderly people in Portugal between May and July 2022. In \u2265\u202f80 year-olds, the second booster dose VE was 81% (95%\u202fCI: 75\u201385) and 82% (95%\u202fCI: 77\u201385), respectively, against COVID-19-related hospitalisation and death. The first booster dose VE was 63% (95%\u202fCI: 55\u201370) in\u2009\u2265\u200980 year-olds and 74% (95%\u202fCI: 66\u201380) in 60\u201379 year-olds against hospitalisation, and 63% (95%\u202fCI:\u202f57\u201369) and 65% (95%\u202fCI: 54\u201374) against death.<\/jats:p>","DOI":"10.2807\/1560-7917.es.2022.27.37.2200697","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T10:15:37Z","timestamp":1663323337000},"update-policy":"https:\/\/doi.org\/10.2807\/1560-7917.es.crp2020","source":"Crossref","is-referenced-by-count":20,"title":["COVID-19 mRNA vaccine effectiveness (second and first booster dose) against hospitalisation and death during Omicron BA.5 circulation: cohort study based on electronic health records, Portugal, May to July 2022"],"prefix":"10.2807","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-2416","authenticated-orcid":false,"given":"Irina","family":"Kislaya","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade P\u00fablica, Escola Nacional de Sa\u00fade P\u00fablica, Universidade NOVA de Lisboa, Lisbon, Portugal"},{"name":"Departamento de Epidemiologia, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Ausenda","family":"Machado","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade P\u00fablica, Escola Nacional de Sa\u00fade P\u00fablica, Universidade NOVA de Lisboa, Lisbon, Portugal"},{"name":"Departamento de Epidemiologia, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Sarah","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Servi\u00e7os Partilhados do Minist\u00e9rio da Sa\u00fade, Lisbon, Portugal"}]},{"given":"Ana Paula","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Departamento de Epidemiologia, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Rafael","family":"Franco","sequence":"additional","affiliation":[{"name":"Servi\u00e7os Partilhados do Minist\u00e9rio da Sa\u00fade, Lisbon, Portugal"}]},{"given":"Pedro Pinto","family":"Leite","sequence":"additional","affiliation":[{"name":"Dire\u00e7\u00e3o de Servi\u00e7os de Informa\u00e7\u00e3o e An\u00e1lise, Dire\u00e7\u00e3o-Geral da Sa\u00fade, Lisbon, Portugal"}]},{"given":"Carlos Matias","family":"Dias","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade P\u00fablica, Escola Nacional de Sa\u00fade P\u00fablica, Universidade NOVA de Lisboa, Lisbon, Portugal"},{"name":"Departamento de Epidemiologia, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Lisbon, Portugal"}]},{"given":"Baltazar","family":"Nunes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade P\u00fablica, Escola Nacional de Sa\u00fade P\u00fablica, Universidade NOVA de Lisboa, Lisbon, Portugal"},{"name":"Departamento de Epidemiologia, Instituto Nacional de Sa\u00fade Doutor Ricardo Jorge, Lisbon, Portugal"}]}],"member":"7995","reference":[{"key":"r1","unstructured":"Dire\u00e7\u00e3o-Geral da Sa\u00fade. Norma 02\/2021 - Campanha de Vacina\u00e7\u00e3o Contra a COVID-19 - Dose de Refor\u00e7o. [Standard 02\/2021 - Vaccination campaign against COVID-19 \u2013 Booster dose]. Lisbon: Dire\u00e7\u00e3o-Geral da Sa\u00fade; 2021. Portuguese. Available from: https:\/\/www.dgs.pt\/normas-orientacoes-e-informacoes\/normas-e-circulares-normativas\/norma-n-0022021-de-30012021-pdf.aspx"},{"key":"r2","unstructured":"European Centre for Disease Prevention and Control (ECDC), European Medicines Agency (EMA). COVID-19\u202f: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines. EMA\/204784\/2022. Stockholm: ECDC, Amsterdam: EMA; 2022. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/public-statement\/covid-19-joint-statement-ecdc-ema-administration-fourth-dose-mrna-vaccines_.pdf"},{"key":"r3","unstructured":"European Centre for Disease Prevention and Control (ECDC), European Medicines Agency (EMA). COVID-19\u202f: Updated joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines. EMA\/635144\/2022. Stockholm: ECDC, Amsterdam: EMA;2022. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/public-statement\/updated-joint-statement-ecdc-ema-additional-booster-doses-covid-19-vaccines_en.pdf"},{"issue":"38","key":"r4","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2021.26.38.2100833","article-title":"mRNA vaccine effectiveness against COVID-19-related hospitalisations and deaths in older adults: a cohort study based on data linkage of national health registries in Portugal, February to August 2021.","volume":"26","author":"Nunes","year":"2021","journal-title":"Euro Surveill"},{"key":"r5","unstructured":"National Institute of Health (INSA) Doutor Ricardo Jorge. Genetic diversity of the novel coronavirus SARS-CoV-2 (COVID-19) in Portugal. 23 August 2022 report. Lisbon: INSA; 2022. Available from: https:\/\/insaflu.insa.pt\/covid19\/relatorios\/PORTUGAL_INSA_SARS_CoV_2_GENETIC_DIVERSITY_situation_report_2022-09-06.pdf"},{"issue":"12","key":"r6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208320","article-title":"The Portuguese version of the european deprivation index: Development and association with all-cause mortality.","volume":"13","author":"Ribeiro","year":"2018","journal-title":"PLoS One"},{"issue":"29","key":"r7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.15585\/mmwr.mm7129e1","article-title":"Effectiveness of 2, 3, and 4 COVID-19 mRNA vaccine doses among immunocompetent adults during periods when SARS-CoV-2 Omicron BA.1 and BA.2\/BA.2.12.1 sublineages predominated - VISION network, 10 States, December 2021-June 2022.","volume":"71","author":"Link-Gelles","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"r8","article-title":"Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: test negative design study.","volume":"378","author":"Grewal","year":"2022","journal-title":"BMJ"},{"key":"r9","doi-asserted-by":"crossref","DOI":"10.2139\/ssrn.4107709","article-title":"Effectiveness of a second COVID-19 vaccine booster on all-cause mortality in long-term care facility residents and in the oldest old: a nationwide, retrospective cohort study in Sweden.","author":"Nordstr\u00f6m","year":"2022","journal-title":"SSRN Electron J"},{"issue":"17","key":"r10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1056\/NEJMoa2201688","article-title":"Fourth dose of BNT162b2 mRNA Covid-19 vaccine in a nationwide setting.","volume":"386","author":"Magen","year":"2022","journal-title":"N Engl J Med"},{"issue":"30","key":"r11","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2022.27.30.2200551","article-title":"Estimation of COVID-19 vaccine effectiveness against hospitalisation in individuals aged \u2265\u200965\u2009years using electronic health registries; a pilot study in four EU\/EEA countries, October 2021 to March 2022.","volume":"27","author":"Sent\u00eds","year":"2022","journal-title":"Euro Surveill"}],"container-title":["Eurosurveillance"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T10:15:48Z","timestamp":1663323348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurosurveillance.org\/content\/10.2807\/1560-7917.ES.2022.27.37.2200697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":11,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2022,9,15]]}},"URL":"https:\/\/doi.org\/10.2807\/1560-7917.es.2022.27.37.2200697","relation":{},"ISSN":["1560-7917"],"issn-type":[{"value":"1560-7917","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,15]]}}}