{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:33:12Z","timestamp":1773282792263,"version":"3.50.1"},"reference-count":20,"publisher":"European Centre for Disease Control and Prevention (ECDC)","issue":"36","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:p>Since autumn 2022, observed numbers of paediatric invasive group A <jats:italic>Streptococcus<\/jats:italic> infections in Portugal (n\u2009=\u200989) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25\/79), mostly with empyema (20\/25), and sepsis (22\/79). A number of cases required admission to intensive care (27\/79) and surgery (35\/79), and the case fatality rate was 5.1% (4\/79). Genomic sequencing (n\u2009=\u200955) revealed multiple genetic lineages, dominated by the M1<jats:sub>UK<\/jats:sub> sublineage (26\/55) and more diverse <jats:italic>emm<\/jats:italic>12 isolates (12\/55).<\/jats:p>","DOI":"10.2807\/1560-7917.es.2023.28.36.2300427","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T10:15:48Z","timestamp":1694168148000},"update-policy":"https:\/\/doi.org\/10.2807\/1560-7917.es.crp2020","source":"Crossref","is-referenced-by-count":78,"title":["Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023"],"prefix":"10.2807","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-8473","authenticated-orcid":false,"given":"Catarina","family":"Gouveia","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Pediatric Department, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-0315","authenticated-orcid":false,"given":"Maria Paula","family":"Bajanca-Lavado","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Refer\u00eancia a Infe\u00e7\u00f5es Respirat\u00f3rias a Agentes Bacterianos, Departamento de Doen\u00e7as Infeciosas, Instituto Nacional de Sa\u00fade Dr. Ricardo Jorge, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8691-0771","authenticated-orcid":false,"given":"Rafael","family":"Mamede","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-047X","authenticated-orcid":false,"given":"Ana","family":"Ara\u00fajo Carvalho","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Pediatric Department, Hospital de Dona Estef\u00e2nia, Centro Hospitalar Universit\u00e1rio de Lisboa Central, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-5215","authenticated-orcid":false,"given":"Fernanda","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Hospital Pedi\u00e1trico, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"}]},{"given":"Jos\u00e9","family":"Melo-Cristino","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-6233","authenticated-orcid":false,"given":"Mario","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7567-2405","authenticated-orcid":false,"given":"Ana","family":"Fri\u00e3es","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"name":"Portuguese Group for the Study of Streptococcal Infections","sequence":"additional","affiliation":[]},{"name":"Portuguese Study Group of Pediatric Invasive Streptococcal Disease","sequence":"additional","affiliation":[]}],"member":"7995","reference":[{"key":"r1","unstructured":"European Centre for Disease Prevention and Control (ECDC). 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