{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:47:50Z","timestamp":1765234070153,"version":"3.46.0"},"reference-count":0,"publisher":"Diving and Hyperbaric Medicine Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diving Hyperb Med"],"abstract":"<jats:p>Introduction: Gas narcosis impairs divers when diving deeper. Pupillometry is sensitive to alcohol intoxication and it has been used in anaesthesia to assess nitrous oxide narcosis. It is a potential novel method to quantify narcosis in diving. The aim of this study was to evaluate pupillometry for objective measurement of narcosis during exposure to hyperbaric air or nitrous oxide.\nMethod: Pupil size in 16 subjects was recorded directly at surface pressure and during air breathing at 608 kPa (equivalent to 50 metres\u2019 seawater depth) in a hyperbaric chamber. Another 12 subjects were exposed to nitrous oxide at end-tidal percentages of 20, 30 and 40% in random order at surface pressure. Pupil size and pupil light reflex were recorded at baseline and at each level of nitrous oxide exposure.\nResults: Pupil size did not significantly change during exposure to hyperbaric air or nitrous oxide. The pupil light reflex, evaluated using percentage constriction and minimum diameter after exposure to a light stimulus, was affected significantly only during the highest nitrous oxide exposure \u2013 an end-tidal level of 40%.\nConclusion: Pupillometry is insensitive to the narcotic effect of air at 608 kPa in the dry hyperbaric environment and to the effects of low dose nitrous oxide. Pupillometry is not suitable as a monitoring method for gas narcosis in diving.<\/jats:p>","DOI":"10.28920\/dhm50.2.115-120","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T20:49:23Z","timestamp":1592254163000},"page":"115-120","source":"Crossref","is-referenced-by-count":2,"title":["Pupillometry is not sensitive to gas narcosis in divers breathing hyperbaric air or normobaric nitrous oxide"],"prefix":"10.28920","volume":"50","author":[{"name":"Department of Anaesthesiology, University of Auckland, Auckland, New Zealand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier CE","family":"Vrijdag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Deep Dive Dubai, Dubai, United Arab Emirates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"van Waart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Anaesthesiology, University of Auckland, Auckland, New Zealand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie W","family":"Sleigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Anaesthesiology, University of Auckland, Auckland, New Zealand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Anaesthesia, Waikato Hospital, Hamilton, New Zealand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Anaesthesiology, University of Auckland, Auckland, New Zealand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Anaesthesia, Auckland City Hospital, Auckland, New Zealand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11463","published-online":{"date-parts":[[2020,6,30]]},"container-title":["Diving and Hyperbaric Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:17:30Z","timestamp":1765232250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dhmjournal.com\/images\/IndividArticles\/50June\/Vrijdag_Pupillometry_2019-58(581).pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6,30]]}},"URL":"https:\/\/doi.org\/10.28920\/dhm50.2.115-120","relation":{},"ISSN":["2209-1491"],"issn-type":[{"type":"electronic","value":"2209-1491"}],"subject":[],"published":{"date-parts":[[2020,6,30]]}}}