{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:03:59Z","timestamp":1761649439253,"version":"3.30.2"},"reference-count":27,"publisher":"Diving and Hyperbaric Medicine Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diving Hyperb Med"],"abstract":"<jats:p>Introduction: Diving utilising closed circuit pure oxygen rebreather systems has become popular in professional settings. One of the hazards the oxygen diver faces is central nervous system oxygen toxicity (CNS-OT), causing potentially fatal convulsions. At the same time, divers frequently travel by boat, often suffering seasickness. The over-the-counter medication meclizine is an anticholinergic and antihistaminergic agent that has gained popularity in the treatment of seasickness. Reports have shown the inhibitory effect that acetylcholine has on glutamate, a main component in the mechanism leading to CNS-OT seizure. The goal of the present study was to test the effect of meclizine on the latency to CNS-OT seizures under hyperbaric oxygen conditions.\nMethods: Twenty male mice were exposed twice to 608 kPa (6 atmospheres) absolute pressure while breathing oxygen after administration of control solution (carboxymethyl cellulose solvent) or drug solution (meclizine) in a randomised crossover design. Latency to tonic-clonic seizures was visually measured.\nResults: Mean latency to seizure did not significantly differ between the control group (414 s, standard deviation \n[SD] 113 s) and meclizine group (434 s, SD 174 s).\nConclusions: Based on results from this animal model, meclizine may be an appropriate option for divers suffering from seasickness, who plan on diving using pure oxygen rebreather systems.<\/jats:p>","DOI":"10.28920\/dhm54.4.296-300","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T06:25:12Z","timestamp":1734416712000},"page":"296-300","source":"Crossref","is-referenced-by-count":1,"title":["Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model"],"prefix":"10.28920","volume":"54","author":[{"name":"Motion Sickness and Human Performance Laboratory, The Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8749-6078","authenticated-orcid":false,"given":"Guy","family":"Wiener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jamison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Motion Sickness and Human Performance Laboratory, The Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Tal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Motion Sickness and Human Performance Laboratory, The Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11463","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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