{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:30:06Z","timestamp":1789623006034,"version":"build-2803163510"},"reference-count":0,"publisher":"Diving and Hyperbaric Medicine Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diving Hyperb Med"],"abstract":"<jats:p>Introduction: Divers often increase their fraction of inspired oxygen (FIO2) to decrease their risk of decompression sickness. However, breathing elevated pressures of oxygen can cause central nervous system oxygen toxicity (CNS-OT). This study aimed to review the literature describing the effect of hyperoxia on the electroencephalogram (EEG), thus exploring the potential for real-time detection of an impending CNS-OT seizure.\nMethods: We searched Medline, Embase, Scopus, and Web of Science for articles that reported EEG measures accompanying hyperoxic ventilation (FIO2 = 1.0 \u00b1 hyperbaric pressure) in healthy participants. We included peer-reviewed journal articles, books, and government reports with no language or date restrictions. Randomised controlled trials and cross-over studies were included; case reports were excluded. We used the Newcastle-Ottawa scale to evaluate evidence quality.\nResults: Our search strategy returned 1,025 unique abstracts; we analysed the full text of 46 articles; 22 articles (16 studies) were included for review. Study cohorts were typically small and comprised of male non-divers. We discovered a variety of EEG analysis methods: studies performed spectral analysis (n = 12), the analysis of sensory-evoked potentials (n = 4), connectivity\/complexity analysis (n = 3), source localisation (n = 1), and expert qualitative analyses (n = 4). Studies of severe exposures (long duration at hyperbaric pressure) typically reported qualitative measures, and studies of mild exposures typically reported quantitative measures.\nConclusions: There is a need for a large randomised controlled trial reporting quantitative measures to better understand the effect of hyperoxia on the EEG, thus enabling the development of real-time monitoring of CNS-OT risk.<\/jats:p>","DOI":"10.28920\/dhm55.2.154-163","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T20:06:14Z","timestamp":1750190774000},"page":"154-163","source":"Crossref","is-referenced-by-count":2,"title":["Electroencephalographic (EEG) changes accompanying normal breathing of concentrated oxygen (hyperoxic ventilation) by healthy adults: a systematic review"],"prefix":"10.28920","volume":"55","author":[{"name":"Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland, New Zealand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-6083","authenticated-orcid":false,"given":"Lachlan D","family":"Barnes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke E","family":"Hallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Mechanical Engineering, University of Auckland, Auckland, New Zealand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier CE","family":"Vrijdag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland, New Zealand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11463","published-online":{"date-parts":[[2025,6,30]]},"container-title":["Diving and Hyperbaric Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T20:06:19Z","timestamp":1750190779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dhmjournal.com\/index.php\/journals?view=article&id=359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.28920\/dhm55.2.154-163","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.16.24313766","asserted-by":"object"}]},"ISSN":["2209-1491"],"issn-type":[{"value":"2209-1491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}