{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:11:00Z","timestamp":1774408260528,"version":"3.50.1"},"reference-count":0,"publisher":"Diving and Hyperbaric Medicine Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diving Hyperb Med"],"abstract":"<jats:p>Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency for which hyperbaric oxygen therapy (HBOT) is a potential treatment. This study aimed to evaluate the effectiveness of HBOT in treating ISSNHL, with a focus on the timing of treatment and its impact on hearing outcomes, while also considering other factors such as demographic characteristics, clinical parameters, and treatment methods.\nMethods: This retrospective cohort study analysed 70 ISSNHL patients (April 2019 to August 2024) who received steroid treatment (oral, intratympanic or both). Patients were divided into early HBOT (&amp;#x0003C; 12 days), late HBOT (13\u201322 days), salvage HBOT (&amp;#x0003E; 22 days), and no HBOT groups. Hearing improvement, measured by pure-tone audiometry (PTA), defined the treatment outcome.\nResults: Significant PTA improvements were observed in most groups (median changes: early HBOT 33.8 dB [n = 15], late HBOT 6.9 dB [n = 16], salvage HBOT 0.0 dB [n = 5], no HBOT 11.9 dB [n = 34]), with early HBOT showing greater gains than late HBOT (P &amp;#x0003C; 0.001), salvage HBOT (P = 0.001), and no HBOT (P = 0.002). Receiver operating characteristic (ROC) analysis indicated that treatment within 10.5 days predicted marked improvement (AUC = 0.883, P &amp;#x0003C; 0.001), and linear regression showed that each day\u2019s delay reduced PTA improvement by 0.832 dB (P &amp;#x0003C; 0.001).\nConclusions: HBOT is effective in restoring hearing in patients suffering from ISSNHL and early treatment is associated with better outcome.<\/jats:p>","DOI":"10.28920\/dhm56.1.41-47","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:41:58Z","timestamp":1774406518000},"page":"41-47","source":"Crossref","is-referenced-by-count":0,"title":["Treatment success in relation to timing of hyperbaric oxygen therapy in idiopathic sudden sensorineural hearing loss"],"prefix":"10.28920","volume":"56","author":[{"given":"Cheuk-Yin","family":"Lun","sequence":"first","affiliation":[{"name":"Accident and Emergency Department, Queen Elizabeth Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan-Leong","family":"Au Yeung","sequence":"additional","affiliation":[{"name":"Accident and Emergency Department, Queen Elizabeth Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuk-Fai","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing-Wa","family":"Yan","sequence":"additional","affiliation":[{"name":"Hyperbaric Oxygen Therapy Centre, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin-Bong","family":"Tang","sequence":"additional","affiliation":[{"name":"Hyperbaric Oxygen Therapy Centre, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11463","published-online":{"date-parts":[[2026,3,31]]},"container-title":["Diving and Hyperbaric Medicine Journal"],"original-title":[],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T02:42:00Z","timestamp":1774406520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.dhmjournal.com\/index.php?option=com_content&view=article&id=404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,31]]}},"URL":"https:\/\/doi.org\/10.28920\/dhm56.1.41-47","relation":{},"ISSN":["2209-1491"],"issn-type":[{"value":"2209-1491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}