{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:33:34Z","timestamp":1791477214589,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Abstract The EFSA Panel\u00a0on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re\u2010evaluating the safety of \u03b2\u2010cyclodextrin (E\u00a0459) as a food additive. \u03b2\u2010Cyclodextrin is a non\u2010reducing cyclic oligosaccharide consisting of seven \u03b1\u20101,4\u2010linked d\u2010glucopyranosyl units. The Scientific Committee on Food (SCF) allocated an acceptable daily intake (ADI) of 5\u00a0mg\/kg body weight (bw) per day to \u03b2\u2010cyclodextrin (E\u00a0459) in 1996. \u03b2\u2010Cyclodextrin is poorly absorbed following oral administration in animals and humans. It is hydrolysed to maltose and glucose by the gut microflora and endogenous amylases in the colon; consequently, \u03b2\u2010cyclodextrin levels in tissues and serum are low (&lt;\u00a01%). \u03b2\u2010Cyclodextrin has a low acute oral toxicity. Short\u2010term and subchronic toxicity studies were available in rats and dogs. In rats, the main reported effect was an adaptive enlargement of the caecum, resulting from consumption of poorly digestible carbohydrates. From a 6\u2010month study in rats, a no observed adverse effect levels (NOAEL) of 600\u00a0mg\/kg bw per day was identified and from a 52\u2010week dogs study, the NOAEL was 466 and 476\u00a0mg\/kg bw per day in males and females, respectively. The Panel\u00a0considered that there was no indication for genotoxicity of \u03b2\u2010cyclodextrin. From a chronic toxicity studies in rats, a NOAEL of 654 and 864\u00a0mg\/kg bw per day in males and females, respectively, was identified. Carcinogenicity studies in mice and rats were available and no evidence for carcinogenicity was found. The Panel\u00a0concluded that, based on the available toxicological database, there is no reason to revise the current ADI of 5\u00a0mg\/kg bw per day for \u03b2\u2010cyclodextrin. Based on the available reported use and use levels, the Panel\u00a0also concluded that the ADI was exceeded in the refined brand\u2010loyal scenario (considered the most relevant scenario) in all population groups except for infants at the mean and in all population groups at the 95th percentile.<\/jats:p>","DOI":"10.2903\/j.efsa.2016.4628","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T03:58:28Z","timestamp":1482292708000},"source":"Crossref","is-referenced-by-count":36,"title":["Re\u2010evaluation of \u03b2\u2010cyclodextrin (E\u00a0459) as a food additive"],"prefix":"10.2903","volume":"14","author":[{"name":"EFSA Panel\u00a0on Food Additives and Nutrient Sources added to Food (ANS)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Crebelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Di Domenico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Frutos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Galtier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Gundert\u2010Remy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Leblanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Lindtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Moldeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mosesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Parent\u2010Massin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Oskarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Stankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ine","family":"Waalkens\u2010Berendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf Antonius","family":"Woutersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Younes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Chrysafidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"G\u00fcrtler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tobback","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Arcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Rincon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Lambr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2016.4628_ref1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0041-008X(63)90048-6","article-title":"The utilization of Schardinger dextrins by the rat","volume":"5","author":"Andersen","year":"1963","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.2903\/j.efsa.2016.4628_ref2","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1021\/jf00126a025","article-title":"Absorption, distribution and excretion of beta\u2010cyclodextrin and glucosyl\u2010beta\u2010cyclodextrin in rats","volume":"32","author":"Antenucci","year":"1984","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.2903\/j.efsa.2016.4628_ref3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0890-6238(95)00026-7","article-title":"The reproductive and developmental toxicity profile of beta\u2010cyclodextrin in rodents","volume":"9","author":"Barrow","year":"1995","journal-title":"Reproductive Toxicology"},{"key":"10.2903\/j.efsa.2016.4628_ref4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0278-6915(94)00149-I","article-title":"Beta\u2010Cyclodextrin: 52\u2010week toxicity studies in the rat and dog","volume":"33","author":"Bellringer","year":"1995","journal-title":"Food and Chemical Toxicology"},{"key":"10.2903\/j.efsa.2016.4628_ref5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2174\/157340106778699485","article-title":"Cyclodextrins as food additives and in food processing","volume":"2","author":"Cravotto","year":"2006","journal-title":"Current Nutrition and Food Science"},{"issue":"1","key":"10.2903\/j.efsa.2016.4628_ref6","doi-asserted-by":"publisher","first-page":"438","DOI":"10.2903\/j.efsa.2007.438","article-title":"Scientific opinion of the Scientific Committee related to uncertainties in dietary exposure assessment","volume":"5","author":"EFSA","year":"2007","journal-title":"EFSA Journal"},{"issue":"3","key":"10.2903\/j.efsa.2016.4628_ref7","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.2903\/j.efsa.2011.2097","article-title":"Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment","volume":"9","author":"EFSA","year":"2011","journal-title":"EFSA Journal"},{"issue":"3","key":"10.2903\/j.efsa.2016.4628_ref8","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.2903\/j.efsa.2011.1970","article-title":"Evaluation of the FoodEx, the food classification system applied to the development of the EFSA Comprehensive European Food Consumption Database","volume":"9","author":"EFSA","year":"2011","journal-title":"EFSA Journal"},{"issue":"6","key":"10.2903\/j.efsa.2016.4628_ref9","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.2903\/j.efsa.2014.3697","article-title":"Statement on a conceptual framework for the risk assessment of certain food additives re\u2010evaluated under Commission Regulation (EU) No 257\/2010","volume":"12","author":"EFSA ANS Panel","year":"2014","journal-title":"EFSA Journal"},{"issue":"10","key":"10.2903\/j.efsa.2016.4628_ref10","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.2903\/j.efsa.2009.1351","article-title":"Scientific Opinion on arsenic in food","volume":"7","author":"EFSA CONTAM Panel","year":"2009","journal-title":"EFSA Journal"},{"issue":"4","key":"10.2903\/j.efsa.2016.4628_ref11","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.2903\/j.efsa.2010.1570","article-title":"Scientific Opinion on lead in food","volume":"8","author":"EFSA CONTAM Panel","year":"2010","journal-title":"EFSA Journal"},{"issue":"10","key":"10.2903\/j.efsa.2016.4628_ref12","doi-asserted-by":"publisher","first-page":"282","DOI":"10.2903\/j.efsa.2005.282","article-title":"Opinion on a request form EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic","volume":"3","author":"EFSA Scientific Committee","year":"2005","journal-title":"EFSA Journal"},{"issue":"7","key":"10.2903\/j.efsa.2016.4628_ref13","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2903\/j.efsa.2009.1051","article-title":"Guidance of the Scientific Committee on Transparency in the Scientific Aspects of Risk Assessments carried out by EFSA. Part 2: General Principles","volume":"7","author":"EFSA Scientific Committee","year":"2009","journal-title":"EFSA Journal"},{"issue":"9","key":"10.2903\/j.efsa.2016.4628_ref14","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.2903\/j.efsa.2011.2379","article-title":"Scientific opinion on genotoxicity testing strategies applicable to food and feed safety assessment","volume":"9","author":"EFSA Scientific Committee","year":"2011","journal-title":"EFSA Journal"},{"issue":"3","key":"10.2903\/j.efsa.2016.4628_ref15","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.2903\/j.efsa.2012.2579","article-title":"Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data","volume":"10","author":"EFSA Scientific Committee","year":"2012","journal-title":"EFSA Journal"},{"key":"10.2903\/j.efsa.2016.4628_ref16","unstructured":"EMA (European Medicines Agency), 2014. Background review for cyclodextrins used as excipients In the context of the revision of the guideline on \u2018Excipients in the label and package leaflet of medicinal products for human use\u2019 (CPMP\/463\/00 Rev. 1) Draft report published in support to the propylene glycol Q&A document. Available online: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Report\/2014\/12\/WC500177936.pdf"},{"key":"10.2903\/j.efsa.2016.4628_ref17","unstructured":"EPA (Enviromental Protection Agency), 2011. Toxicological review of trichloroethylene (CAS No 79\u201001\u20106) in support of summary information on the integrated risk information system (IRIS). EPA\/635\/R\u201009\/011D. June 2011. Washington, DC."},{"key":"10.2903\/j.efsa.2016.4628_ref18","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/jn\/123.4.676","article-title":"Fate of beta\u2010cyclodextrin in the human intestine","volume":"123","author":"Flourie","year":"1993","journal-title":"Journal of Nutrition"},{"key":"10.2903\/j.efsa.2016.4628_ref19","first-page":"367","article-title":"Cyclodextrin nephrosis in the rat","volume":"83","author":"Frank","year":"1976","journal-title":"American Journal of Pathology"},{"key":"10.2903\/j.efsa.2016.4628_ref20","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1023\/A:1015929720063","article-title":"The pharmacokinetics of beta\u2010cyclodextrin and hydroxypropyl\u2010beta\u2010cyclodextrin in the rat","volume":"7","author":"Frijlink","year":"1990","journal-title":"Pharmaceutical Research"},{"key":"10.2903\/j.efsa.2016.4628_ref21","first-page":"1042","article-title":"Absorption, distribution, excretion and metabolism of orally administered 14C\u2010beta\u2010cyclodextrin in rat","volume":"35","author":"Gerloczy","year":"1985","journal-title":"Arzneimittel\u2010Forschung"},{"key":"10.2903\/j.efsa.2016.4628_ref22","first-page":"316","article-title":"Histochemical studies of beta\u2010cyclodextrin nephrosis in rats","volume":"32","author":"Hiasa","year":"1981","journal-title":"Journal of Nara Medical Association"},{"key":"10.2903\/j.efsa.2016.4628_ref23","volume-title":"Trichloroethylene, tetrachloroethylene and some other chlorinated agents","author":"IARC","year":"2014"},{"key":"10.2903\/j.efsa.2016.4628_ref24","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives), 1993. 795. Beta\u2010cyclodextrin. WHO Food Additive Series 32. Available online: http:\/\/www.inchem.org\/documents\/jecfa\/jecmono\/v32je13.htm"},{"key":"10.2903\/j.efsa.2016.4628_ref25","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives), 1995. 843. Beta\u2010cyclodextrin. WHO Food Additive Series 35. Available online: http:\/\/www.inchem.org\/documents\/jecfa\/jecmono\/v35je12.htm"},{"key":"10.2903\/j.efsa.2016.4628_ref26","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives), 2000. Guidelines for the preparation of toxicological working papers for the Joint FAO\/WHO Expert Committee on Food Additives. Geneva, Switzerland. Available online: http:\/\/www.who.int\/foodsafety\/chem\/jecfa\/en\/tox_guidelines.pdf"},{"key":"10.2903\/j.efsa.2016.4628_ref27","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives), 2006. Monograph 1. Combined compendium of food additive specifications. Available online: http:\/\/www.fao.org\/ag\/agn\/jecfa-additives\/search.html"},{"key":"10.2903\/j.efsa.2016.4628_ref28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0731-7085(99)00299-X","article-title":"Simultaneous determination of alpha, beta and gamma cyclodextrins by LC","volume":"22","author":"Kinalekar","year":"2000","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"10.2903\/j.efsa.2016.4628_ref29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0040-6031(93)85107-K","article-title":"Thermal decomposition of cyclodextrins (\u03b1\u2010, \u03b2\u2010, \u03b3\u2010 and modified \u03b2\u2010CyD) and of metal\u2010(\u03b2\u2010CyD) complexes in the solid phase","volume":"217","author":"Kohata","year":"1993","journal-title":"Thermochimica Acta"},{"key":"10.2903\/j.efsa.2016.4628_ref30","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1248\/bpb.19.1068","article-title":"Absorption, distribution and excretion of beta\u2010cyclodextrin and glucosyl\u2010beta\u2010cyclodextrin in rats","volume":"19","author":"Kubota","year":"1996","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.2903\/j.efsa.2016.4628_ref31","doi-asserted-by":"crossref","unstructured":"L\u00f3pez LA, Alonso C and Gilliland SE, 2009. Analytical Method for Quantification b\u2010Cyclodextrin in Milk, Cream and Butter by LC. Chromatographia 2009, 69, May (No. 9\/10).","DOI":"10.1365\/s10337-009-1022-2"},{"key":"10.2903\/j.efsa.2016.4628_ref32","first-page":"449","article-title":"Chronic toxicity study of beta\u2010cyclodextrin in rats","volume":"10","author":"Makita","year":"1975","journal-title":"Oyo Yakuri"},{"key":"10.2903\/j.efsa.2016.4628_ref33","unstructured":"Martindale , online. The Complete Drug Reference. Available online. www.medicinescomplete.com\/mc\/martindale [Accessed: 15th September 2016]"},{"key":"10.2903\/j.efsa.2016.4628_ref34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5059\/yukigoseikyokaishi.35.116","article-title":"Cyclodextrins and their application","volume":"35","author":"Mifune","year":"1977","journal-title":"Journal of Synthetic Organic Chemistry Japan"},{"key":"10.2903\/j.efsa.2016.4628_ref35","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 1983a. OECD Guideline for the testing of chemicals, No 473. Genetic toxicology: in\u00a0vitro mammalian cytogenetic test. Adopted on 26 May 1983."},{"key":"10.2903\/j.efsa.2016.4628_ref36","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 1983b. OECD Guideline for the testing of chemicals, No 474. Genetic toxicology: micronucleus test."},{"key":"10.2903\/j.efsa.2016.4628_ref37","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 1983c. OECD Guideline for the testing of chemicals, 416. Two\u2010generation reproduction toxicity study. Adopted on 26 May 1983."},{"key":"10.2903\/j.efsa.2016.4628_ref38","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 2001. OECD Guideline for the testing of chemicals, 414. Prenatal developmental toxicity study. Adopted on 22 January 2001."},{"key":"10.2903\/j.efsa.2016.4628_ref39","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 2009. OECD Guideline for the testing of chemicals, 451. Carcinogenicity studies. Adopted on 9 September 2009."},{"key":"10.2903\/j.efsa.2016.4628_ref40","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 2014a. OECD Guideline for the testing of chemicals TG 473. In Vitro Mammalian Chromosome Aberration Test. Adopted 26 Sep 2014."},{"key":"10.2903\/j.efsa.2016.4628_ref41","unstructured":"OECD (Organisation for Economic Co\u2010operation and Development), 2014b. OECD Guideline for the testing of chemicals, TG 474. Mammalian erythrocyte micronucleus test. Adopted on 26 September 2014."},{"key":"10.2903\/j.efsa.2016.4628_ref42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/10915819109078639","article-title":"Subchronic toxicity of orally administered beta\u2010cyclodextrin in rats","volume":"10","author":"Olivier","year":"1991","journal-title":"Journal of American College of Toxicology"},{"key":"10.2903\/j.efsa.2016.4628_ref43","first-page":"373","article-title":"Beta\u2010cyclodextrin as an aid to peritoneal dialysis, renal toxicity of beta\u2010cyclodextrin in the rat","volume":"19","author":"Perrin","year":"1978","journal-title":"Research Communications in Chemical Pathology and Pharmacology"},{"key":"10.2903\/j.efsa.2016.4628_ref44","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s002170000213","article-title":"Safety aspects of residual b\u2010cyclodextrin in egg treated for cholesterol removal","volume":"211","author":"Rao","year":"2000","journal-title":"European Food Research and Technology"},{"key":"10.2903\/j.efsa.2016.4628_ref45","unstructured":"SCF (Scientific Committee for Food), 1997. Reports of the Scientific Committee for Food. Forty\u2010first series Opinion on \u03b2\u2010cyclodextrin manufactured by the action of the enzyme cyclogylcosyltransferase obtained from Bacillus\u00a0circulans on partially hydrolysed starch (expressed on 13 December 1996), p. 27\u201331."},{"key":"10.2903\/j.efsa.2016.4628_ref46","unstructured":"SCF (Scientific Committee for Food), 2000a. Opinion on \u03b2\u2010cyclodextrin produced using cycloglycosyltransferase from a recombinant Paenibacillus macerans. Adopted by the SCF on 22 June 2000. SCF\/CS\/ADD\/AMI 48 Final."},{"key":"10.2903\/j.efsa.2016.4628_ref47","unstructured":"SCF (Scientific Committee for Food), 2000b. Opinion on \u03b2\u2010cyclodextrin produced using cycloglycosyltransferase from a recombinant Bacillus licheniformis. Adopted by the SCF on 22 June 20000. SCF\/CS\/ADD\/AMI 52 Final."},{"key":"10.2903\/j.efsa.2016.4628_ref48","unstructured":"SCF (Scientific Committee for Food), 2001. Guidance on submissions for food additive evaluations by the Scientific Committee on Food. SCF\/CS\/ADD\/GEN\/26 Final. 12 July 2001."},{"key":"10.2903\/j.efsa.2016.4628_ref49","unstructured":"SCF (Scientific Committee for Food), 2002a. Opinion of the Scientific Committee on Food on the safety of the presence of safrole (1\u2010allyl\u20103,4\u2010 methylene dioxy benzene) in flavourings and other food ingredients with flavouring properties (adopted on 12 December 2001). SCF\/CS\/FLAV\/FLAVOUR\/6 ADD3 Final. 9 January 2002."},{"key":"10.2903\/j.efsa.2016.4628_ref50","unstructured":"SCF (Scientific Committee for Food), 2002b. Minutes of the 132nd Plenary Meeting of the Scientific Committee on Food held on 15\/16\/17 April 2002 in Brussels. Agenda Item 4: Matters arising from previous plenary meeting. As referred to by EFSA Scientific Committee, 2005."},{"key":"10.2903\/j.efsa.2016.4628_ref51","unstructured":"SCF (Scientific Committee for Food), 2002c. Opinion of the Scientific Committee on Food on new findings regarding the presence of acrylamide in food (expressed on 3 July 2002). SCF\/CS\/CNTM\/CONT\/4 Final. 3 July 2002."},{"key":"10.2903\/j.efsa.2016.4628_ref52","unstructured":"SCF (Scientific Committee for Food), 2002d. Opinion of the Scientific Committee on Food on the risks to human health of Polycyclic Aromatic Hydrocarbons in food (expressed on 4 December 2002)."},{"key":"10.2903\/j.efsa.2016.4628_ref53","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/0192623307310945","article-title":"Cyclodextrins","volume":"36","author":"Stella","year":"2008","journal-title":"Toxicologic Pathology"},{"key":"10.2903\/j.efsa.2016.4628_ref54","first-page":"167","volume-title":"Drugs, Biochemistry and Metabolism","author":"Klebovich","year":"1981a"},{"key":"10.2903\/j.efsa.2016.4628_ref55","unstructured":"TemaNord , 2002. Food Additives in Europe 2000. Status of safety assessments of food additives presently permitted in the EU. E444 Sucrose acetate isobutyrate, pp. 444\u2013447."},{"key":"10.2903\/j.efsa.2016.4628_ref56","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0278-6915(97)00128-2","article-title":"Carcinogenicity study of beta\u2010cyclodextrin in F344 rats","volume":"35","author":"Toyoda","year":"1997","journal-title":"Food and Chemical Toxicology"},{"key":"10.2903\/j.efsa.2016.4628_ref57","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.nbt.2011.01.003","article-title":"Formation of acrylamide from glucans and asparagine","volume":"28","author":"Tsutsumiuchi","year":"2011","journal-title":"New Biotechnology"},{"key":"10.2903\/j.efsa.2016.4628_ref58","unstructured":"Van Dokkum W and Van der Beek EJ, 1990. Tolerance of \u00df\u2010cyclodextrin in man. Unpublished report No. V 90.419 of TNO, to AVEBE, Foxhol, The Netherlands, submitted to WHO by Dr R Scheuplein, USFDA, Washington, DC, USA, as referred to by JECFA, 1993."},{"key":"10.2903\/j.efsa.2016.4628_ref59","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s002040050224","article-title":"Investigation of potential oncogenetic effects of beta\u2010cyclodextrin in the rat and mouse","volume":"69","author":"Waner","year":"1995","journal-title":"Archives of Toxicology"},{"key":"10.2903\/j.efsa.2016.4628_ref60","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.carbpol.2013.10.042","article-title":"Preparation, characterization, and thermal stability of \u03b2\u2010cyclodextrin\/soybean lecithin inclusion complex","volume":"101","author":"Wang","year":"2014","journal-title":"Carbohydrate Polymers"}],"container-title":["EFSA Journal"],"original-title":[],"link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2903\/j.efsa.2016.4628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.2903\/j.efsa.2016.4628\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:20:31Z","timestamp":1778512831000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.2903\/j.efsa.2016.4628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":60,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.2903\/j.efsa.2016.4628","relation":{},"ISSN":["1831-4732","1831-4732"],"issn-type":[{"value":"1831-4732","type":"print"},{"value":"1831-4732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}