{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:17:15Z","timestamp":1778159835489,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of copper chelates of lysine and glutamic acid (Copper\u2010LG) as a nutritional feed additive for all animal species. The EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed (FEEDAP) concludes that, owing to safety considerations, Copper\u2010LG should not be used in water for drinking. Copper\u2010LG is safe for chickens for fattening; this conclusion can be extrapolated to all animal species and categories provided that the maximum authorised levels in the EU for total copper in feed are not exceeded. No increases in the copper content of animal tissues\/products are expected from the use of Copper\u2010LG in animal nutrition. There is no indication that the toxicity of Copper\u2010LG is essentially different from that of inorganic divalent copper. The use of Copper\u2010LG in animal nutrition is of no concern for consumer safety provided that the maximum authorised total copper in feed is respected. Owing to the copper and nickel content of Copper\u2010LG, the handling of the additive, poses a risk to users by inhalation. The additive is considered as a skin and respiratory sensitiser; it is corrosive to the eye while it is non\u2010irritant to skin. The additive is intended to be a substitute for other authorised copper additives and will not further increase the environmental burden of copper; therefore, the FEEDAP Panel\u00a0considers that the use of the additive in animal nutrition would not pose an additional risk for the environment. Copper\u2010LG is a bioavailable source of copper, comparable to the standard inorganic copper source, and therefore, the additive is efficacious in meeting the birds copper requirements; this conclusion can be extrapolated to all animal species\/categories. The FEEDAP Panel\u00a0posed a recommendation concerning the description of the additive.<\/jats:p>","DOI":"10.2903\/j.efsa.2019.5728","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T09:35:00Z","timestamp":1560850500000},"source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of copper chelates of lysine and glutamic acid as a feed additive for all animal species"],"prefix":"10.2903","volume":"17","author":[{"name":"EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed (FEEDAP)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Bampidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Azimonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"de Lourdes Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryline","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojca","family":"Kos Durjava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"L\u00f3pez\u2010Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secundino","family":"L\u00f3pez Puente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baltasar","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Pechov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Petkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Edoardo","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud","family":"Woutersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cubadda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Flachowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"L\u00f3pez\u2010G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2019.5728_ref1","unstructured":"EC (European Commission), 2003. Opinion of the Scientific Committee on Food (SCF) on the Upper Intake Level of Copper (27 March 2003). Available online: https:\/\/ec.europa.eu\/food\/sites\/food\/files\/safety\/docs\/sci-com_scf_out176_en.pdf"},{"key":"10.2903\/j.efsa.2019.5728_ref2","unstructured":"EC (European Commission), 2011. Recommendation from the Scientific Committee on Occupational Exposure Limits (SCOEL) for nickel and inorganic nickel compounds. Employment, Social Affairs and Inclusion. SCOEL\/SUM\/85, June 2011. Available online: http:\/\/ec.europa.eu\/social\/BlobServlet?docId=3803&langId=en"},{"key":"10.2903\/j.efsa.2019.5728_ref3","unstructured":"EC (European Commission), 2014. Recommendation from the Scientific Committee on Occupational Exposure Limits for Copper and its inorganic compounds. SCOEL\/SUM\/171, March 2014. 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