{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:03:54Z","timestamp":1775786634308,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.2903\/j.efsa.2020.6002","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T11:35:16Z","timestamp":1582112116000},"source":"Crossref","is-referenced-by-count":14,"title":["Safety and efficacy of oct\u20101\u2010en\u20103\u2010ol, pent\u20101\u2010en\u20103\u2010ol, oct\u20101\u2010en\u20103\u2010one, oct\u20101\u2010en\u20103\u2010yl acetate, isopulegol and 5\u2010methylhept\u20102\u2010en\u20104\u2010one, belonging to chemical group 5 and of isopulegone and \u03b1\u2010damascone belonging to chemical group 8 when used as flavourings for all animal species"],"prefix":"10.2903","volume":"18","author":[{"name":"EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed (FEEDAP)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasileios","family":"Bampidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Azimonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryline","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojca","family":"Kos Durjava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"L\u00f3pez\u2010Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Secundino","family":"L\u00f3pez Puente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baltasar","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Pechov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Petkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Edoardo","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruud","family":"Woutersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Brantom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Westendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Gregoretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Manini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2020.6002_ref1","doi-asserted-by":"crossref","DOI":"10.1201\/9781420063165","volume-title":"Handbook of Essential Oils: Science, Technology and Applications","author":"H\u00fcsn\u00fc Can Baser","year":"2009"},{"key":"10.2903\/j.efsa.2020.6002_ref2","volume-title":"Fenaroli's Handbook of Flavor Ingredients","author":"Burdock","year":"2009"},{"key":"10.2903\/j.efsa.2020.6002_ref3","first-page":"1567","article-title":"Metabolism of (R)\u2010(+)\u2010pulegone in F344 rats","volume":"29","author":"Chen","year":"2003","journal-title":"Drug Metabolism and Disposition"},{"key":"10.2903\/j.efsa.2020.6002_ref4","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0006-2952(97)00072-5","article-title":"Molecular basis for deficient acetaminophen glucuronidation in cats","volume":"53","author":"Court","year":"1997","journal-title":"Biochemical Pharmacology"},{"key":"10.2903\/j.efsa.2020.6002_ref5","unstructured":"Cox GE, Bailey DE and Morgareidge K, 1974. 90\u2010Day feeding study in rats with 2\u2010octen\u20104\u2010one. Private Communication to FEMA by G.E Cox et\u00a0al. Cited in: FAS 50, WHO 2003. Study no. 21034. Unpublished report submitted by EFFA to FLAVIS Secretariat. EFFA Submission 2001\u20103."},{"key":"10.2903\/j.efsa.2020.6002_ref6","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority), 2008. Technical Guidance of the Scientific Panel\u00a0on Additives and Products or Substances used in Animal Feed (FEEDAP) for assessing the safety of feed additives for the environment. EFSA Journal 2008;6(10):842, 28 pp. https:\/\/doi.org\/10.2903\/j.efsa.2008.842","DOI":"10.2903\/j.efsa.2008.842"},{"key":"10.2903\/j.efsa.2020.6002_ref7","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority), 2009. Opinion of the Scientific Panel\u00a0on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on Flavouring Group Evaluation 57 (FGE.57): consideration of two structurally related pulegone metabolites and one ester thereof evaluated by JECFA (55th meeting). EFSA Journal 2009;7(5):1079, 17 pp. https:\/\/doi.org\/10.2903\/j.efsa.2009.1079","DOI":"10.2903\/j.efsa.2009.1079"},{"key":"10.2903\/j.efsa.2020.6002_ref8","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2012a. Scientific Opinion on Flavouring Group Evaluation 204 (FGE.204): consideration of genotoxicity data on representatives for 18 mono\u2010unsaturated, aliphatic, \u03b1,\u03b2\u2010unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19 by EFSA. EFSA Journal 2012;10(12):2992, 25 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2012.2992","DOI":"10.2903\/j.efsa.2012.2992"},{"key":"10.2903\/j.efsa.2020.6002_ref9","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2012b. Scientific Opinion on Flavouring Group Evaluation 205 (FGE.205): consideration of genotoxicity data on representatives for 13 \u03b1,\u03b2\u2010unsaturated aliphatic ketones with terminal double bonds and precursors from chemical subgroup 1.2.2 of FGE.19 by EFSA. EFSA Journal 2012;10(10):2902, 22 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2012.2902","DOI":"10.2903\/j.efsa.2012.2902"},{"key":"10.2903\/j.efsa.2020.6002_ref10","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2014. Scientific Opinion on Flavouring Group Evaluation 210 Revision 1 (FGE.210Rev1): consideration of genotoxic potential for a,\u00df\u2010unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19. EFSA Journal 2014;12(2):3587, 35 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2014.3587","DOI":"10.2903\/j.efsa.2014.3587"},{"key":"10.2903\/j.efsa.2020.6002_ref11","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2015. Scientific opinion on Flavouring Group Evaluation 210 Revision 2 (FGE.210Rev2): consideration of genotoxic potential for \u03b1,\u03b2\u2010unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19. EFSA Journal 2015;13(7):4172, 33 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2015.4172","DOI":"10.2903\/j.efsa.2015.4172"},{"key":"10.2903\/j.efsa.2020.6002_ref12","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), 2016a. Scientific opinion of Flavouring Group Evaluation 205 Revision 1 (FGE.205Rev1): consideration of genotoxicity data on representatives for 13 \u03b1,\u03b2\u2010unsaturated aliphatic ketones with terminal double bonds and precursors from chemical subgroup 1.2.2 of FGE.19. EFSA Journal 2016;14(7):4535, 23 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2016.4535","DOI":"10.2903\/j.efsa.2016.4535"},{"key":"10.2903\/j.efsa.2020.6002_ref13","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), Silano V, Bolognesi C, Castle L, Cravedi J\u2010P, Engel K\u2010H, Fowler P, Franz R, Grob K, G\u00fcrtler R, Hus\u00f8y T, K\u00e4renlampi S, Milana MR, Penninks A, Tavares Po\u00e7as MF, Smith A, Tlustos C, W\u00f6lfle D, Zorn H, Zugravu C\u2010A, Beckman Sundh U, Brimer L, Mulder G, Binderup M\u2010L, Crebelli R, Marcon F, Marzin D, Mosesso P, Kovalkovicov\u00e1 N and Mennes W, 2016b. Scientific Opinion on Flavouring Group Evaluation 63, Revision 3 (FGE.63Rev3): aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th and 69th meetings) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched\u2010chain carboxylic acids evaluated by EFSA in FGE.07Rev4. EFSA Journal 2017;15(1):4662, 41 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2017.4662","DOI":"10.2903\/j.efsa.2017.4662"},{"key":"10.2903\/j.efsa.2020.6002_ref14","doi-asserted-by":"crossref","unstructured":"EFSA CEF Panel (EFSA Panel\u00a0on Food Contact Materials, Enzymes, Flavourings and Processing Aids), Silano V, Bolognesi C, Castle L, Cravedi J\u2010P, Engel K\u2010H, Fowler P, Franz R, Grob K, G\u00fcrtler R, Hus\u00f8y T, K\u00e4renlampi S, Milana MR, Penninks A, Tavares Po\u00e7as MF, Smith A, Tlustos C, W\u00f6lfle D, Zorn H, Zugravu C\u2010A, Beckman Sundh U, Brimer L, Mulder G, Marcon F, Anastassiadou M, Carf\u00ed M and Mennes W, 2017. Scientific Opinion on Flavouring Group Evaluation 57, Revision 1 (FGE.57Rev1): consideration of isopulegone and three flavouring substances evaluated by JECFA (55th meeting). EFSA Journal 2017;15(3):4727, 24 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2017.4727","DOI":"10.2903\/j.efsa.2017.4727"},{"key":"10.2903\/j.efsa.2020.6002_ref15","doi-asserted-by":"crossref","unstructured":"EFSA FAF Panel (EFSA Panel\u00a0on Food Additives and Flavourings), Younes M, Aquilina G, Castle L, Engel K\u2010H, Fowler P, Frutos Fernandez MJ, F\u00fcrst P, Gundert\u2010Remy U, G\u00fcrtler R, Hus\u00f8y T, Moldeus P, Oskarsson A, Shah R, Waalkens\u2010Berendsen I, W\u00f6lfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carf\u00ed M, Vianello G and Mennes W, 2019a. Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration ofgenotoxicity data on representatives for 17 monounsaturated, aliphatic, \u03b1,\u03b2\u2010unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA Journal 2019;17(7):5750, 26 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2019.5750","DOI":"10.2903\/j.efsa.2019.5750"},{"key":"10.2903\/j.efsa.2020.6002_ref16","doi-asserted-by":"crossref","unstructured":"EFSA FAF Panel (EFSA Panel\u00a0on Food Additives and Flavourings), Younes M, Aquilina G, Castle L, Engel K\u2010H, Fowler P, Frutos Fernandez MJ, F\u00fcrst P, Gundert\u2010Remy U, G\u00fcrtler R, Hus\u00f8y T, Moldeus P, Oskarsson A, Shah R, Waalkens\u2010Berendsen I, W\u00f6lfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carf\u00ed M, Vianello G and Mennes W, 2019b. Scientific Opinion on Flavouring Group Evaluation 210 Revision 3 (FGE.210Rev3): consideration of genotoxic potential fora,b\u2010unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 ofFGE.19. EFSA Journal 2019;17(5):5676, 42 pp. https:\/\/doi.org\/doi:10.2903\/j.efsa.2019.5676","DOI":"10.2903\/j.efsa.2019.5676"},{"key":"10.2903\/j.efsa.2020.6002_ref17","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed), 2012a. Guidance for the preparation of dossiers for sensory additives. EFSA Journal 2012;10(1):2534, 26 pp. https:\/\/doi.org\/10.2903\/j.efsa.2012.2534","DOI":"10.2903\/j.efsa.2012.2534"},{"key":"10.2903\/j.efsa.2020.6002_ref18","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed), 2012b. Guidance for the preparation of dossiers for additives already authorised for use in food. EFSA Journal 2012;10(1):2538, 4 pp. https:\/\/doi.org\/10.2903\/j.efsa.2012.2538","DOI":"10.2903\/j.efsa.2012.2538"},{"key":"10.2903\/j.efsa.2020.6002_ref19","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed), 2012c. Guidance for establishing the safety of additives for the consumer. EFSA Journal 2012;10(1):2537, 12 pp. https:\/\/doi.org\/10.2903\/j.efsa.2012.2537","DOI":"10.2903\/j.efsa.2012.2537"},{"key":"10.2903\/j.efsa.2020.6002_ref20","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed), 2012d. Guidance on studies concerning the safety of use of the additive for users\/workers. EFSA Journal 2012;10(1):2539, 5 pp. https:\/\/doi.org\/10.2903\/j.efsa.2012.2539","DOI":"10.2903\/j.efsa.2012.2539"},{"key":"10.2903\/j.efsa.2020.6002_ref21","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed), 2015. Scientific opinion on the safety and efficacy of saturated and unsaturated aliphatic secondary alcohols, ketones and esters with esters containing secondary alcohols belonging chemical group 5 when used as flavourings for all animal species. EFSA Journal 2015;13(11):4268, 21 pp. https:\/\/doi.org\/10.2903\/j.efsa.2015.4268","DOI":"10.2903\/j.efsa.2015.4268"},{"key":"10.2903\/j.efsa.2020.6002_ref22","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel\u00a0on Additives and Products or Substances used in Animal Feed), 2016. Scientific opinion on the safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species. EFSA Journal 2016;14(6):4475, 26 pp. https:\/\/doi.org\/10.2903\/j.efsa.2016.4475","DOI":"10.2903\/j.efsa.2016.4475"},{"key":"10.2903\/j.efsa.2020.6002_ref23","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1021\/jf034702u","article-title":"In vivo studies on the metabolism of the monoterpene pulegone in humans using the metabolism of ingestion\u2010correlated amounts (MICA) approach: explanation for the toxicity differences between (S)\u2010(\u2010)\u2010and (R)\u2010(+)\u2010Pulegone","volume":"51","author":"Engel","year":"2003","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.2903\/j.efsa.2020.6002_ref24","unstructured":"FAO , 2006. FAO JECFA Monographs 1: Combined Compendium of Food Additive Specifications\u2014Joint FAO\/WHO Expert Committee on Food Additives\u2014All specifications monographs from the 1st to the 65th meeting (1956\u20132005). Volume 4. Analytical methods, test procedures and laboratory solutions used by and referenced in the food additive specifications. Food and Agricultural Organization of the United Nations, Rome. Available online: http:\/\/www.fao.org\/docrep\/009\/a0691e\/a0691e00.htm"},{"key":"10.2903\/j.efsa.2020.6002_ref25","unstructured":"Koetzner L, 2013. Isopulegol (microencapsulated): a 90\u2010day dietary study in rats. Product Safety Labs. Study no. 35334. December 2, 2013. Unpublished report submitted by EFFA to FLAVIS Secretariat."},{"key":"10.2903\/j.efsa.2020.6002_ref26","unstructured":"Posternak JM, 1964. Subacute toxicity (90 days) report on 1\u2010octen\u20103\u2010ol (amyl vinyl carbinol). Private Communication. Submitted to WHO by the Flavors and Extract Manufacturers Association. Cited in: JECFA, 2003. EFFA submission 2001\u20103."},{"key":"10.2903\/j.efsa.2020.6002_ref27","unstructured":"WHO (World Health Organization), 2000. Evaluation of certain food additives. Fifty\u2010first meeting of the Joint FAO\/WHO Expert Committee on Food Additives. Geneva, 9\u201318 June 1998. WHO Technical Report Series, No 891. WHO, Geneva, Switzerland."},{"key":"10.2903\/j.efsa.2020.6002_ref28","unstructured":"WHO (World Health Organization), 2001. Evaluation of certain food additives and contaminants. Fifty\u2010fifth report of the Joint FAO\/WHO Expert Committee on Food Additives. Geneva, 6\u201315 June 2000. WHO Technical Report Series, No 901. WHO, Geneva, Switzerland."}],"container-title":["EFSA Journal"],"original-title":[],"link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2903\/j.efsa.2020.6002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.2903\/j.efsa.2020.6002\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T06:56:39Z","timestamp":1675148199000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.2903\/j.efsa.2020.6002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":28,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2903\/j.efsa.2020.6002","relation":{},"ISSN":["1831-4732","1831-4732"],"issn-type":[{"value":"1831-4732","type":"print"},{"value":"1831-4732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}